| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $141,819 | 8 | $749,852 | Dec 18 | 20th Century Fox International | false |
| 2 | Prince of Persia: The Sands of Time | - | - | - | $136,620 | 8 | $136,620 | May 28 | Walt Disney Pictures | false |
| 3 | Clash of the Titans | - | - | - | $128,986 | 8 | $129,357 | Apr 2 | Warner Bros. | false |
| 4 | Iron Man 2 | - | - | - | $122,460 | 8 | $122,460 | May 7 | United International Pictures | false |
| 5 | Inception | - | - | - | $116,115 | 6 | $150,913 | Jul 30 | Warner Bros. | false |
| 6 | Robin Hood | - | - | - | $95,945 | 8 | $95,945 | May 14 | United International Pictures | false |
| 7 | Unstoppable | - | - | - | $93,908 | 8 | $124,487 | Nov 12 | 20th Century Fox International | false |
| 8 | Alice in Wonderland | - | - | - | $92,105 | 7 | $92,105 | Mar 5 | Walt Disney Pictures | false |
| 9 | The Twilight Saga: Eclipse | - | - | - | $91,154 | 6 | $96,386 | Jul 2 | NuMetro Distribution | false |
| 10 | Knight and Day 2010 Re-release | - | - | - | $91,037 | 6 | $91,037 | Jul 23 | 20th Century Fox International | false |
| 11 | The Last Airbender | - | - | - | $84,719 | 9 | $84,719 | Sep 10 | United International Pictures | false |
| 12 | Valentine's Day | - | - | - | $84,604 | 7 | $84,604 | Feb 12 | Warner Bros. | false |
| 13 | Salt | - | - | - | $83,943 | 7 | $84,122 | Aug 13 | Sony Pictures Releasing | false |
| 14 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $81,777 | 9 | $81,777 | Nov 26 | Warner Bros. | false |
| 15 | Sex and the City 2 | - | - | - | $77,220 | 7 | $77,220 | May 28 | Warner Bros. | false |
| 16 | Shrek Forever After | - | - | - | $76,242 | 7 | $76,242 | Jul 16 | United International Pictures | false |
| 17 | Sherlock Holmes | - | - | - | $70,842 | 8 | $124,091 | Dec 31 | Warner Bros. | false |
| 18 | Step Up 3D | - | - | - | $66,766 | 6 | $66,766 | Aug 27 | NuMetro Distribution | false |
| 19 | Eat Pray Love | - | - | - | $60,422 | 6 | $60,422 | Oct 8 | Sony Pictures Releasing | false |
| 20 | The Sorcerer's Apprentice | - | - | - | $58,960 | 7 | $58,960 | Aug 20 | Walt Disney Pictures | false |
| 21 | Despicable Me | - | - | - | $56,194 | 8 | $56,194 | Oct 1 | United International Pictures | false |
| 22 | Toy Story 3 | - | - | - | $51,809 | 5 | $51,809 | Jun 18 | Walt Disney Pictures | false |
| 23 | The Karate Kid | - | - | - | $51,149 | 7 | $51,149 | Jul 30 | Sony Pictures Releasing | false |
| 24 | Wall Street: Money Never Sleeps | - | - | - | $49,298 | 6 | $50,151 | Sep 24 | 20th Century Fox International | false |
| 25 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $47,770 | 4 | $47,770 | Feb 19 | 20th Century Fox International | false |
| 26 | The Bounty Hunter | - | - | - | $46,806 | 6 | $46,806 | Apr 9 | Sony Pictures Releasing | false |
| 27 | Date Night | - | - | - | $43,026 | 3 | $43,026 | Apr 9 | 20th Century Fox International | false |
| 28 | Cop Out | - | - | - | $39,054 | 6 | $39,054 | Mar 26 | Warner Bros. | false |
| 29 | Invictus | - | - | - | $36,207 | 6 | $50,988 | Jan 22 | Warner Bros. | false |
| 30 | The Other Guys | - | - | - | $35,038 | 6 | $35,038 | Sep 17 | Sony Pictures Releasing | false |
| 31 | Did You Hear About the Morgans? | - | - | - | $34,770 | 6 | $34,770 | Jan 15 | Sony Pictures Releasing | false |
| 32 | The Princess and the Frog | - | - | - | $33,928 | 4 | $33,928 | Mar 26 | Walt Disney Pictures | false |
| 33 | The Social Network | - | - | - | $33,004 | 6 | $33,610 | Oct 29 | Sony Pictures Releasing | false |
| 34 | Old Dogs | - | - | - | $32,458 | 7 | $32,458 | Jan 29 | Walt Disney Pictures | false |
| 35 | It's Complicated | - | - | - | $31,411 | 5 | $50,785 | Feb 12 | United International Pictures | false |
| 36 | Takers 2010 Re-release | - | - | - | $30,327 | 5 | $30,327 | Oct 22 | Sony Pictures Releasing | false |
| 37 | Green Zone 2010 Re-release | - | - | - | $30,094 | 6 | $30,094 | Jun 11 | United International Pictures | false |
| 38 | Up in the Air | - | - | - | $29,542 | 5 | $29,542 | Mar 5 | United International Pictures | false |
| 39 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $27,805 | 5 | $76,049 | Dec 23 | 20th Century Fox International | false |
| 40 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $27,496 | 4 | $27,496 | Aug 13 | Warner Bros. | false |
| 41 | The Blind Side | - | - | - | $26,093 | 4 | $33,024 | Mar 12 | Warner Bros. | false |
| 42 | The A-Team | - | - | - | $25,579 | 5 | $25,579 | Aug 20 | 20th Century Fox International | false |
| 43 | Death at a Funeral | - | - | - | $24,036 | 5 | $24,036 | Jun 4 | Sony Pictures Releasing | false |
| 44 | Legion | - | - | - | $23,095 | 5 | $23,095 | Mar 12 | Sony Pictures Releasing | false |
| 45 | The Wolfman | - | - | - | $20,051 | 5 | $20,051 | Feb 26 | United International Pictures | false |
| 46 | Tooth Fairy | - | - | - | $19,790 | 3 | $19,790 | Mar 19 | 20th Century Fox International | false |
| 47 | Avatar 2010 Special Edition | - | - | - | $19,139 | 4 | $58,787 | Oct 15 | 20th Century Fox International | false |
| 48 | Predators | - | - | - | $18,460 | 2 | $18,460 | Aug 6 | 20th Century Fox International | false |
| 49 | The Back-up Plan | - | - | - | $18,408 | 5 | $18,408 | Jun 18 | Sony Pictures Releasing | false |
| 50 | Marmaduke | - | - | - | $17,771 | 3 | $17,771 | Jun 11 | 20th Century Fox International | false |
| 51 | Tangled | - | - | - | $17,350 | 7 | $91,744 | Dec 3 | Walt Disney Pictures | false |
| 52 | How to Train Your Dragon | - | - | - | $16,089 | 6 | $52,773 | Apr 2 | United International Pictures | false |
| 53 | Shutter Island | - | - | - | $15,341 | 6 | $32,795 | Apr 16 | United International Pictures | false |
| 54 | Charlie St. Cloud | - | - | - | $14,402 | 7 | $14,402 | Oct 22 | United International Pictures | false |
| 55 | Grown Ups | - | - | - | $14,387 | 5 | $14,387 | Sep 3 | Sony Pictures Releasing | false |
| 56 | Law Abiding Citizen | - | - | - | $13,643 | 2 | $13,643 | Jan 15 | NuMetro Distribution | false |
| 57 | The Last Song | - | - | - | $12,192 | 4 | $12,192 | Jun 11 | Walt Disney Pictures | false |
| 58 | Armored | - | - | - | $11,805 | 5 | $11,805 | Mar 26 | Sony Pictures Releasing | false |
| 59 | Our Family Wedding | - | - | - | $11,224 | 1 | $13,148 | Jul 30 | 20th Century Fox International | false |
| 60 | When in Rome | - | - | - | $10,732 | 5 | $20,353 | Apr 16 | Walt Disney Pictures | false |
| 61 | The Losers | - | - | - | $8,330 | 4 | $8,330 | Jul 16 | Warner Bros. | false |
| 62 | Vampires Suck | - | - | - | $5,126 | 1 | $5,126 | Sep 3 | NuMetro Distribution | false |
| 63 | Alvin and the Chipmunks | - | - | - | $3,839 | 5 | $65,097 | Dec 28 | 20th Century Fox International | false |
| 64 | Gamer | - | - | - | $3,643 | 2 | $8,353 | Dec 4 | NuMetro Distribution | false |
| 65 | The Twilight Saga: New Moon | - | - | - | $2,606 | 4 | $94,115 | Nov 27 | NuMetro Distribution | false |
| 66 | Couples Retreat | - | - | - | $2,330 | 6 | $49,279 | Nov 27 | United International Pictures | false |
| 67 | A Christmas Carol | - | - | - | $1,759 | 3 | $30,848 | Dec 25 | Walt Disney Pictures | false |
| 68 | The Time Traveler's Wife | - | - | - | $1,680 | 2 | $19,061 | Nov 6 | NuMetro Distribution | false |
| 69 | 2012 | - | - | - | $1,135 | 6 | $138,829 | Nov 13 | Sony Pictures Releasing | false |
| 70 | My Sister's Keeper | - | - | - | $710 | 2 | $24,731 | Oct 9 | NuMetro Distribution | false |
| 71 | Aliens in the Attic | - | - | - | $472 | 2 | $10,771 | Dec 11 | 20th Century Fox International | false |
| 72 | Pandorum | - | - | - | $226 | 2 | $2,551 | Feb 5 | NuMetro Distribution | false |
