| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Toy Story 3 | - | - | - | $6,339,232 | 95 | $6,339,322 | Jun 18 | Walt Disney Pictures | false |
| 2 | Shrek Forever After | - | - | - | $5,828,718 | 87 | $5,984,037 | Jul 9 | United International Pictures | false |
| 3 | Tangled | - | - | - | $4,628,706 | 78 | $6,863,748 | Nov 26 | Walt Disney Pictures | false |
| 4 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $4,380,876 | 119 | $4,743,014 | Nov 19 | Warner Bros. | false |
| 5 | Alice in Wonderland | - | - | - | $4,335,113 | 92 | $4,335,113 | Mar 5 | Walt Disney Pictures | false |
| 6 | The Twilight Saga: Eclipse | - | - | - | $3,220,661 | 96 | $3,220,661 | Jul 2 | - | false |
| 7 | The Zero Hour | - | - | - | $3,029,772 | 45 | $3,947,360 | Oct 8 | - | false |
| 8 | Clash of the Titans | - | - | - | $3,010,415 | 93 | $3,010,415 | Apr 16 | Warner Bros. | false |
| 9 | The Karate Kid | - | - | - | $2,639,233 | 78 | $2,639,233 | Aug 6 | Sony Pictures Releasing | false |
| 10 | The Sorcerer's Apprentice | - | - | - | $2,603,094 | 66 | $2,603,094 | Sep 3 | Walt Disney Pictures | false |
| 11 | Grown Ups | - | - | - | $2,541,731 | 70 | $2,541,731 | Jul 30 | Sony Pictures Releasing | false |
| 12 | Old Dogs | - | - | - | $2,468,108 | 51 | $2,468,108 | Feb 5 | United International Pictures | false |
| 13 | Resident Evil: Afterlife | - | - | - | $2,447,898 | 73 | $2,447,898 | Sep 10 | Sony Pictures Releasing | false |
| 14 | Despicable Me | - | - | - | $2,321,604 | 83 | $2,321,604 | Aug 13 | United International Pictures | false |
| 15 | The Last Airbender | - | - | - | $2,262,106 | 63 | $2,262,106 | Aug 27 | United International Pictures | false |
| 16 | Prince of Persia: The Sands of Time | - | - | - | $2,221,861 | 80 | $2,221,861 | Jul 23 | Walt Disney Pictures | false |
| 17 | Iron Man 2 | - | - | - | $1,903,726 | 95 | $1,903,726 | Apr 30 | United International Pictures | false |
| 18 | TRON: Legacy | - | - | - | $1,795,313 | 70 | $3,419,740 | Dec 17 | United International Pictures | false |
| 19 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $1,785,409 | 56 | $1,785,409 | Oct 1 | Warner Bros. | false |
| 20 | Tooth Fairy | - | - | - | $1,769,552 | 60 | $1,769,552 | Jan 15 | 20th Century Fox International | false |
| 21 | Avatar | - | - | - | $1,754,461 | 100 | $9,060,514 | Dec 18 | 20th Century Fox International | false |
| 22 | How to Train Your Dragon | - | - | - | $1,719,199 | 76 | $1,719,199 | Mar 26 | United International Pictures | false |
| 23 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $1,686,812 | 88 | $1,686,812 | Aug 27 | Warner Bros. | false |
| 24 | A Nightmare on Elm Street | - | - | - | $1,672,304 | 55 | $1,672,304 | May 14 | Warner Bros. | false |
| 25 | Inception | - | - | - | $1,570,718 | 67 | $1,570,718 | Aug 6 | Warner Bros. | false |
| 26 | Brother | - | - | - | $1,556,003 | 25 | $1,556,003 | Jul 2 | - | false |
| 27 | Megamind | - | - | - | $1,536,588 | 92 | $2,512,019 | Dec 10 | United International Pictures | false |
| 28 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $1,517,744 | 69 | $1,517,744 | Feb 12 | 20th Century Fox International | false |
| 29 | Robin Hood | - | - | - | $1,466,773 | 69 | $1,466,773 | Jun 4 | United International Pictures | false |
| 30 | Date Night | - | - | - | $1,299,140 | 61 | $1,299,140 | Apr 9 | 20th Century Fox International | false |
| 31 | Sherlock Holmes | - | - | - | $1,169,558 | 80 | $1,169,558 | Jan 15 | Warner Bros. | false |
| 32 | Saw 3D | - | - | - | $1,151,381 | 42 | $1,151,381 | Oct 29 | Walt Disney Pictures | false |
| 33 | Marmaduke | - | - | - | $1,110,195 | 54 | $1,110,195 | May 28 | 20th Century Fox International | false |
| 34 | Knight and Day 2010 Re-release | - | - | - | $1,064,750 | 61 | $1,064,750 | Jul 16 | 20th Century Fox International | false |
| 35 | Salt | - | - | - | $1,017,195 | 62 | $1,017,195 | Aug 20 | Sony Pictures Releasing | false |
| 36 | The Book of Eli | - | - | - | $996,734 | 63 | $996,734 | Mar 26 | Sony Pictures Releasing | false |
| 37 | Life as We Know It | - | - | - | $955,630 | 50 | $967,666 | Nov 12 | Warner Bros. | false |
| 38 | Paranormal Activity 2 | - | - | - | $930,599 | 45 | $930,599 | Nov 5 | United International Pictures | false |
| 39 | The Wolfman | - | - | - | $914,570 | 58 | $914,570 | Feb 12 | United International Pictures | false |
| 40 | Furry Vengeance | - | - | - | $899,826 | 32 | $899,826 | Sep 3 | - | false |
| 41 | Edge of Darkness | - | - | - | $828,534 | 50 | $828,534 | Mar 5 | Warner Bros. | false |
| 42 | The Other Guys | - | - | - | $789,539 | 31 | $789,539 | Sep 17 | Sony Pictures Releasing | false |
| 43 | The Back-up Plan | - | - | - | $730,413 | 40 | $730,413 | May 21 | Sony Pictures Releasing | false |
| 44 | Valentine's Day | - | - | - | $717,222 | 50 | $717,222 | Feb 12 | Warner Bros. | false |
| 45 | The Town | - | - | - | $701,482 | 54 | $701,482 | Oct 15 | Warner Bros. | false |
| 46 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $686,159 | 77 | $1,748,845 | Dec 25 | 20th Century Fox International | false |
| 47 | The Bounty Hunter | - | - | - | $673,976 | 40 | $673,976 | Mar 31 | Sony Pictures Releasing | false |
| 48 | 9 meses | - | - | - | $672,296 | 27 | $873,641 | Nov 12 | - | false |
| 49 | Nanny McPhee Returns | - | - | - | $636,120 | 37 | $636,120 | May 14 | United International Pictures | false |
| 50 | Shutter Island | - | - | - | $634,691 | 44 | $634,691 | Mar 12 | United International Pictures | false |
| 51 | Habana Eva | - | - | - | $626,926 | 23 | $707,988 | Aug 6 | - | false |
| 52 | The A-Team | - | - | - | $624,787 | 63 | $624,787 | Jun 11 | 20th Century Fox International | false |
| 53 | Due Date | - | - | - | $615,547 | 69 | $615,547 | Nov 5 | Warner Bros. | false |
| 54 | Legion | - | - | - | $610,696 | 41 | $610,696 | May 7 | Sony Pictures Releasing | false |
| 55 | Predators | - | - | - | $597,533 | 46 | $597,533 | Oct 1 | 20th Century Fox International | false |
| 56 | Eat Pray Love | - | - | - | $570,588 | 40 | $570,588 | Oct 29 | Sony Pictures Releasing | false |
| 57 | Ninja Assassin | - | - | - | $531,874 | 44 | $531,874 | Jan 1 | Warner Bros. | false |
| 58 | The Last Exorcism | - | - | - | $510,499 | 28 | $762,737 | Dec 10 | - | false |
| 59 | Sex and the City 2 | - | - | - | $499,160 | 58 | $499,160 | Jun 4 | Warner Bros. | false |
| 60 | Cop Out | - | - | - | $458,560 | 43 | $458,560 | May 28 | Warner Bros. | false |
| 61 | The Social Network | - | - | - | $453,918 | 35 | $616,663 | Dec 3 | Sony Pictures Releasing | false |
| 62 | Going the Distance | - | - | - | $451,433 | 40 | $451,433 | Sep 3 | Warner Bros. | false |
| 63 | Vampires Suck | - | - | - | $406,169 | 43 | $406,169 | Oct 29 | 20th Century Fox International | false |
| 64 | Green Zone 2010 Re-release | - | - | - | $404,205 | 28 | $444,506 | Jun 25 | United International Pictures | false |
| 65 | It's Complicated | - | - | - | $389,027 | 40 | $389,027 | May 28 | United International Pictures | false |
| 66 | Cirque du Freak: The Vampire's Assistant | - | - | - | $384,644 | 49 | $384,644 | Feb 5 | United International Pictures | false |
| 67 | The Stepfather | - | - | - | $380,295 | 30 | $380,295 | Jan 8 | Sony Pictures Releasing | false |
| 68 | Piranha 3D | - | - | - | $379,696 | 33 | $379,696 | Oct 15 | - | false |
| 69 | Couples Retreat | - | - | - | $370,826 | 33 | $370,826 | Mar 26 | United International Pictures | false |
| 70 | Armored | - | - | - | $366,227 | 30 | $366,227 | Feb 19 | Sony Pictures Releasing | false |
| 71 | The Blind Side | - | - | - | $355,921 | 39 | $355,921 | Mar 19 | Warner Bros. | false |
| 72 | 2012 | - | - | - | $354,495 | 95 | $8,046,572 | Nov 13 | Sony Pictures Releasing | false |
| 73 | Paranormal Activity | - | - | - | $349,537 | 38 | $349,537 | Apr 23 | - | false |
| 74 | Tinker Bell and the Great Fairy Rescue | - | - | - | $342,725 | 15 | $345,335 | Sep 24 | Walt Disney Pictures | false |
| 75 | Invictus | - | - | - | $340,248 | 34 | $340,248 | Feb 5 | Warner Bros. | false |
| 76 | Remember Me | - | - | - | $339,681 | 20 | $339,681 | Jun 4 | - | false |
| 77 | Las Caras del Diablo | - | - | - | $315,079 | 15 | $315,079 | Sep 17 | - | false |
| 78 | The Box | - | - | - | $310,060 | 33 | $311,040 | Oct 1 | - | false |
| 79 | Solomon Kane | - | - | - | $308,868 | 27 | $312,949 | Nov 12 | - | false |
| 80 | My Bloody Valentine | - | - | - | $290,728 | 25 | $293,961 | Feb 12 | - | false |
| 81 | Avatar 2010 Special Edition | - | - | - | $284,557 | 14 | $306,686 | Nov 12 | 20th Century Fox International | false |
| 82 | The Spy Next Door 2010 Re-release | - | - | - | $284,155 | 31 | $1,656,148 | Dec 25 | - | false |
| 83 | Unrest 2009 Re-release | - | - | - | $281,972 | 17 | $281,972 | Jan 8 | - | false |
| 84 | Toy Story 2 2009 Re-release | - | - | - | $277,773 | 9 | $277,773 | May 28 | Walt Disney Pictures | false |
| 85 | The Haunting in Connecticut | - | - | - | $275,080 | 24 | $275,080 | Mar 26 | - | false |
| 86 | Up in the Air | - | - | - | $265,980 | 35 | $265,980 | Jan 22 | United International Pictures | false |
| 87 | Case 39 | - | - | - | $265,440 | 29 | $265,440 | Apr 9 | United International Pictures | false |
| 88 | Toy Story 2009 Re-release | - | - | - | $255,035 | 8 | $255,035 | May 14 | Walt Disney Pictures | false |
| 89 | Wall Street: Money Never Sleeps | - | - | - | $254,351 | 42 | $254,351 | Nov 26 | 20th Century Fox International | false |
| 90 | Did You Hear About the Morgans? | - | - | - | $253,991 | 40 | $253,991 | Apr 16 | Sony Pictures Releasing | false |
| 91 | Cheila: Una casa pa' Maíta | - | - | - | $244,505 | 15 | $244,505 | Jul 16 | - | false |
| 92 | Muerte en alto contraste | - | - | - | $235,349 | 22 | $288,032 | Nov 26 | - | false |
| 93 | Zombieland | - | - | - | $226,544 | 30 | $226,544 | Jan 29 | Sony Pictures Releasing | false |
| 94 | SubHysteria | - | - | - | $213,015 | 15 | $213,015 | May 14 | - | false |
| 95 | Eden Lake | - | - | - | $209,253 | 15 | $232,033 | Jun 25 | - | false |
| 96 | The Hurt Locker | - | - | - | $198,231 | 10 | $198,231 | Feb 19 | - | false |
| 97 | Precious | - | - | - | $181,250 | 11 | $181,250 | Feb 26 | - | false |
| 98 | Diary of the Dead 2010 Re-release | - | - | - | $176,083 | 9 | $176,083 | Jun 11 | - | false |
| 99 | Fly Me to the Moon 3D | - | - | - | $162,654 | 18 | $162,654 | Jun 11 | - | false |
| 100 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $161,603 | 23 | $161,603 | May 7 | - | false |
| 101 | The Lovely Bones | - | - | - | $151,657 | 42 | $151,657 | Feb 19 | United International Pictures | false |
| 102 | I Hate Valentine's Day | - | - | - | $150,611 | 15 | $150,611 | Apr 16 | - | false |
| 103 | Taita Boves | - | - | - | $150,247 | 12 | $150,247 | Aug 27 | - | false |
| 104 | Letters to Juliet | - | - | - | $147,122 | 19 | $156,876 | Jul 30 | - | false |
| 105 | Dear John | - | - | - | $141,889 | 15 | $141,889 | Apr 23 | Sony Pictures Releasing | false |
| 106 | Takers 2010 Re-release | - | - | - | $141,799 | 30 | $215,311 | Dec 10 | Sony Pictures Releasing | false |
| 107 | Nine | - | - | - | $130,690 | 10 | $130,690 | Jan 29 | Sony Pictures Releasing | false |
| 108 | The Return 2010 Re-release | - | - | - | $129,063 | 8 | $129,063 | Feb 26 | - | false |
| 109 | The Last Song | - | - | - | $127,211 | 12 | $127,211 | Aug 20 | Walt Disney Pictures | false |
| 110 | Charlie St. Cloud | - | - | - | $126,418 | 23 | $682,233 | Dec 25 | United International Pictures | false |
| 111 | Everybody's Fine | - | - | - | $124,312 | 17 | $124,312 | Apr 9 | Walt Disney Pictures | false |
| 112 | Funny People | - | - | - | $123,884 | 20 | $123,884 | Jan 29 | United International Pictures | false |
| 113 | The Imaginarium of Doctor Parnassus | - | - | - | $113,890 | 10 | $113,890 | Apr 16 | Sony Pictures Releasing | false |
| 114 | 500 Days of Summer | - | - | - | $97,037 | 7 | $97,037 | Mar 26 | 20th Century Fox International | false |
| 115 | Astro Boy | - | - | - | $96,172 | 15 | $96,172 | Jan 29 | - | false |
| 116 | Big Stan | - | - | - | $83,115 | 10 | $83,115 | Feb 26 | - | false |
| 117 | Love Happens | - | - | - | $69,634 | 32 | $69,634 | Nov 5 | - | false |
| 118 | Last Chance Harvey | - | - | - | $66,304 | 16 | $66,304 | May 21 | - | false |
| 119 | Chéri | - | - | - | $63,958 | 5 | $63,958 | Oct 1 | - | false |
| 120 | The Time Traveler's Wife | - | - | - | $57,996 | 9 | $57,996 | Feb 5 | - | false |
| 121 | Desautorizados | - | - | - | $57,691 | 14 | $57,691 | Mar 26 | - | false |
| 122 | Penelope | - | - | - | $57,061 | 11 | $57,061 | Jan 29 | - | false |
| 123 | 9 | - | - | - | $56,076 | 26 | $74,091 | Jun 25 | - | false |
| 124 | Grace Is Gone | - | - | - | $55,092 | 5 | $59,384 | Oct 1 | - | false |
| 125 | My Life in Ruins | - | - | - | $54,687 | 11 | $54,687 | Mar 12 | - | false |
| 126 | The Soloist | - | - | - | $48,167 | 15 | $48,167 | Mar 19 | United International Pictures | false |
| 127 | The Men Who Stare at Goats | - | - | - | $46,882 | 10 | $51,515 | Jul 23 | Sony Pictures Releasing | false |
| 128 | Extremos | - | - | - | $45,567 | 10 | $45,567 | Oct 29 | - | false |
| 129 | The Burning Plain | - | - | - | $45,336 | 2 | $64,366 | Aug 6 | - | false |
| 130 | Street Fighter: The Legend of Chun-Li | - | - | - | $40,802 | 14 | $40,802 | Apr 23 | - | false |
| 131 | El Estudiante 2010 Re-release | - | - | - | $40,099 | 3 | $40,099 | Sep 10 | - | false |
| 132 | My One and Only | - | - | - | $39,487 | 7 | $39,487 | Oct 22 | - | false |
| 133 | A Prophet | - | - | - | $36,425 | 3 | $42,189 | Apr 30 | Sony Pictures Releasing | false |
| 134 | An Education | - | - | - | $33,857 | 5 | $33,857 | Mar 5 | Sony Pictures Releasing | false |
| 135 | Feast 2010 Re-release | - | - | - | $30,281 | 4 | $30,281 | Mar 19 | - | false |
| 136 | DOA: Dead or Alive 2009 Re-release | - | - | - | $27,650 | 12 | $27,650 | Mar 19 | - | false |
| 137 | Amelia | - | - | - | $27,430 | 3 | $49,492 | Dec 25 | 20th Century Fox International | false |
| 138 | Volverte a ver 2010 Re-release | - | - | - | $23,268 | 10 | $23,268 | Mar 5 | - | false |
| 139 | Venezzia | - | - | - | $20,518 | 29 | $1,302,931 | Sep 25 | - | false |
| 140 | Crazy Heart | - | - | - | $20,306 | 3 | $25,971 | Sep 3 | 20th Century Fox International | false |
| 141 | Fame | - | - | - | $19,808 | 10 | $19,808 | Feb 26 | - | false |
| 142 | The Brothers Bloom | - | - | - | $17,996 | 3 | $44,158 | Dec 25 | - | false |
| 143 | I Served the King of England 2010 Re-release | - | - | - | $16,880 | 2 | $35,268 | Dec 10 | - | false |
| 144 | Four Minutes 2010 Re-release | - | - | - | $15,215 | 4 | $48,651 | Dec 17 | - | false |
| 145 | Cell 211 | - | - | - | $8,665 | 3 | $18,105 | Nov 5 | - | false |
| 146 | The Prize | - | - | - | $7,330 | 3 | $7,330 | Jan 8 | - | false |
| 147 | Inland Empire 2010 Re-release | - | - | - | $6,049 | 2 | $7,204 | Oct 8 | - | false |
| 148 | The Magic Flute 2010 Re-release | - | - | - | $5,688 | 2 | $5,688 | Aug 27 | - | false |
| 149 | Tarata | - | - | - | $4,291 | 3 | $4,291 | May 14 | - | false |
| 150 | A Serious Man | - | - | - | $3,388 | 3 | $10,164 | Jun 18 | United International Pictures | false |
| 151 | Fantastic Mr. Fox | - | - | - | $1,853 | 1 | $4,483 | Feb 12 | 20th Century Fox International | false |
| 152 | The Appeared | - | - | - | $1,799 | 1 | $1,799 | Oct 15 | - | false |
| 153 | Kirikou and the Wild Beasts | - | - | - | $1,623 | 2 | $1,623 | Jun 4 | - | false |
| 154 | Parque vía 2010 Re-release | - | - | - | $1,368 | 3 | $1,368 | Oct 22 | - | false |
| 155 | My Best Friend's Girl | - | - | - | $503 | 25 | $409,580 | Nov 20 | - | false |
