| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $718,364 | 12 | $1,131,489 | Dec 18 | 20th Century Fox International | false |
| 2 | Inception | - | - | - | $456,050 | 5 | $504,666 | Jul 23 | Warner Bros. | false |
| 3 | Mr. Bjarnfreðarson | - | - | - | $366,655 | 17 | $608,508 | Dec 26 | - | false |
| 4 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $347,269 | 9 | $366,858 | Nov 19 | Warner Bros. | false |
| 5 | The Secret Spell | - | - | - | $347,060 | 14 | $347,060 | Sep 10 | - | false |
| 6 | Shrek Forever After | - | - | - | $288,880 | 11 | $312,764 | Jul 14 | United International Pictures | false |
| 7 | Toy Story 3 | - | - | - | $245,199 | 10 | $453,707 | Jun 18 | Walt Disney Pictures | false |
| 8 | Despicable Me | - | - | - | $223,298 | 15 | $227,013 | Sep 3 | United International Pictures | false |
| 9 | The Expendables | - | - | - | $218,548 | 4 | $263,958 | Aug 18 | - | false |
| 10 | Alice in Wonderland | - | - | - | $215,744 | 6 | $215,744 | Mar 5 | Walt Disney Pictures | false |
| 11 | Sex and the City 2 | - | - | - | $211,132 | 9 | $245,935 | Jun 4 | Warner Bros. | false |
| 12 | Due Date | - | - | - | $205,925 | 6 | $206,197 | Nov 5 | Warner Bros. | false |
| 13 | Iron Man 2 | - | - | - | $198,156 | 9 | $198,156 | Apr 30 | United International Pictures | false |
| 14 | Mamma Gógó | - | - | - | $190,422 | 5 | $190,422 | Jan 1 | - | false |
| 15 | The Girl Who Kicked the Hornet's Nest | - | - | - | $186,189 | 5 | $186,189 | Feb 19 | - | false |
| 16 | Sherlock Holmes | - | - | - | $178,454 | 7 | $190,960 | Jan 15 | Warner Bros. | false |
| 17 | Salt | - | - | - | $175,440 | 7 | $175,440 | Aug 11 | Sony Pictures Releasing | false |
| 18 | Jackass 3D | - | - | - | $151,933 | 3 | $163,015 | Nov 12 | United International Pictures | false |
| 19 | How to Train Your Dragon | - | - | - | $150,721 | 9 | $168,995 | Apr 2 | United International Pictures | false |
| 20 | The Social Network | - | - | - | $147,432 | 6 | $149,883 | Oct 15 | Sony Pictures Releasing | false |
| 21 | Clash of the Titans | - | - | - | $135,549 | 8 | $136,087 | Apr 9 | Warner Bros. | false |
| 22 | Kick-Ass | - | - | - | $132,564 | 5 | $135,879 | Apr 16 | - | false |
| 23 | The Karate Kid | - | - | - | $129,564 | 6 | $138,074 | Jul 28 | Sony Pictures Releasing | false |
| 24 | The Other Guys | - | - | - | $128,884 | 6 | $130,645 | Sep 3 | Sony Pictures Releasing | false |
| 25 | Robin Hood | - | - | - | $128,839 | 8 | $157,766 | May 14 | United International Pictures | false |
| 26 | Prince of Persia: The Sands of Time | - | - | - | $127,586 | 9 | $146,755 | May 19 | Walt Disney Pictures | false |
| 27 | Step Up 3D | - | - | - | $125,501 | 5 | $125,848 | Aug 25 | - | false |
| 28 | The Twilight Saga: Eclipse | - | - | - | $124,416 | 5 | $155,784 | Jul 2 | - | false |
| 29 | Shutter Island | - | - | - | $120,178 | 4 | $120,750 | Feb 26 | United International Pictures | false |
| 30 | The Town | - | - | - | $119,397 | 5 | $126,288 | Oct 8 | Warner Bros. | false |
| 31 | Eat Pray Love | - | - | - | $118,599 | 5 | $118,599 | Oct 1 | Sony Pictures Releasing | false |
| 32 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $118,156 | 6 | $173,660 | Dec 26 | 20th Century Fox International | false |
| 33 | Jitters | - | - | - | $113,780 | 10 | $114,203 | Oct 15 | - | false |
| 34 | The Chronicles of Narnia: The Voyage of the Dawn Treader | - | - | - | $103,019 | 7 | $133,025 | Dec 10 | 20th Century Fox International | false |
| 35 | Knight and Day 2010 Re-release | - | - | - | $99,799 | 6 | $112,888 | Jul 7 | 20th Century Fox International | false |
| 36 | Valentine's Day | - | - | - | $96,994 | 6 | $97,951 | Feb 12 | Warner Bros. | false |
| 37 | Megamind | - | - | - | $96,841 | 14 | $165,292 | Dec 17 | United International Pictures | false |
| 38 | Dinner for Schmucks | - | - | - | $96,201 | 4 | $96,201 | Oct 1 | United International Pictures | false |
| 39 | Hot Tub Time Machine | - | - | - | $96,161 | 4 | $109,455 | Mar 31 | - | false |
| 40 | Get Him to the Greek | - | - | - | $90,782 | 4 | $93,354 | Jun 4 | United International Pictures | false |
| 41 | It's Complicated | - | - | - | $89,487 | 5 | $91,556 | Jan 29 | United International Pictures | false |
| 42 | Undercurrent | - | - | - | $88,784 | 3 | $101,961 | Oct 4 | - | false |
| 43 | Cloudy with a Chance of Meatballs | - | - | - | $86,543 | 7 | $92,303 | Jan 29 | Sony Pictures Releasing | false |
| 44 | The Bounty Hunter | - | - | - | $83,862 | 4 | $83,862 | Mar 19 | Sony Pictures Releasing | false |
| 45 | Little Fockers | - | - | - | $82,601 | 8 | $148,651 | Dec 26 | United International Pictures | false |
| 46 | Grown Ups | - | - | - | $82,504 | 6 | $135,743 | Jun 24 | Sony Pictures Releasing | false |
| 47 | Killers | - | - | - | $66,856 | 4 | $77,318 | Jun 30 | - | false |
| 48 | TRON: Legacy | - | - | - | $66,164 | 6 | $142,526 | Dec 26 | Walt Disney Pictures | false |
| 49 | Life as We Know It | - | - | - | $65,457 | 5 | $72,330 | Dec 3 | Warner Bros. | false |
| 50 | Date Night | - | - | - | $65,097 | 4 | $65,687 | Apr 9 | 20th Century Fox International | false |
| 51 | Green Zone | - | - | - | $64,727 | 4 | $64,727 | Mar 12 | United International Pictures | false |
| 52 | The Sorcerer's Apprentice | - | - | - | $64,019 | 6 | $87,240 | Aug 6 | Walt Disney Pictures | false |
| 53 | King's Road | - | - | - | $62,389 | 3 | $62,389 | Mar 26 | - | false |
| 54 | Resident Evil: Afterlife | - | - | - | $62,164 | 4 | $62,164 | Sep 10 | Sony Pictures Releasing | false |
| 55 | I Love You Phillip Morris | - | - | - | $61,700 | 3 | $70,789 | Apr 2 | - | false |
| 56 | RED | - | - | - | $61,096 | 4 | $61,096 | Nov 5 | - | false |
| 57 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $61,052 | 7 | $61,052 | Oct 22 | Warner Bros. | false |
| 58 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $60,239 | 6 | $60,239 | Feb 12 | 20th Century Fox International | false |
| 59 | The Book of Eli | - | - | - | $59,353 | 5 | $59,353 | Jan 29 | - | false |
| 60 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $57,498 | 6 | $61,502 | Aug 18 | Warner Bros. | false |
| 61 | Going the Distance | - | - | - | $54,196 | 5 | $55,150 | Sep 17 | Warner Bros. | false |
| 62 | Predators | - | - | - | $53,927 | 4 | $67,080 | Jul 14 | 20th Century Fox International | false |
| 63 | Wall Street: Money Never Sleeps | - | - | - | $52,946 | 4 | $52,946 | Sep 24 | 20th Century Fox International | false |
| 64 | Piranha 3D | - | - | - | $51,512 | 3 | $51,512 | Sep 24 | - | false |
| 65 | The Blind Side | - | - | - | $47,982 | 3 | $47,982 | Mar 12 | Warner Bros. | false |
| 66 | Planet 51 | - | - | - | $47,893 | 6 | $47,893 | Jan 22 | - | false |
| 67 | The Back-up Plan | - | - | - | $47,564 | 3 | $47,564 | May 5 | Sony Pictures Releasing | false |
| 68 | Summerland | - | - | - | $45,629 | 4 | $45,629 | Sep 17 | - | false |
| 69 | The Last Airbender | - | - | - | $45,504 | 5 | $59,077 | Aug 13 | United International Pictures | false |
| 70 | Scott Pilgrim vs. the World | - | - | - | $44,695 | 3 | $54,265 | Aug 25 | United International Pictures | false |
| 71 | Letters to Juliet | - | - | - | $44,336 | 4 | $50,816 | Aug 18 | - | false |
| 72 | The Princess and the Frog | - | - | - | $41,690 | 5 | $59,711 | Dec 26 | Walt Disney Pictures | false |
| 73 | Easy Money | - | - | - | $40,967 | 2 | $46,085 | May 19 | - | false |
| 74 | Inhale | - | - | - | $40,731 | 3 | $40,731 | Oct 22 | - | false |
| 75 | The Wolfman | - | - | - | $40,346 | 5 | $40,346 | Feb 12 | United International Pictures | false |
| 76 | Did You Hear About the Morgans? | - | - | - | $39,430 | 3 | $39,430 | Jan 8 | Sony Pictures Releasing | false |
| 77 | The Next Three Days | - | - | - | $37,499 | 3 | $42,794 | Nov 26 | - | false |
| 78 | Faster | - | - | - | $35,774 | 5 | $37,614 | Dec 3 | Sony Pictures Releasing | false |
| 79 | The Switch | - | - | - | $35,760 | 4 | $35,760 | Oct 22 | - | false |
| 80 | The Ghost Writer | - | - | - | $34,707 | 3 | $34,707 | Sep 3 | - | false |
| 81 | She's Out of My League | - | - | - | $34,545 | 4 | $38,520 | Apr 23 | United International Pictures | false |
| 82 | Hullabaloo | - | - | - | $32,946 | 5 | $96,756 | Dec 26 | - | false |
| 83 | The A-Team | - | - | - | $32,735 | 3 | $103,365 | Jun 16 | 20th Century Fox International | false |
| 84 | Precious | - | - | - | $32,241 | 1 | $32,241 | Feb 26 | - | false |
| 85 | A Turtle's Tale: Sammy's Adventures | - | - | - | $31,416 | 3 | $32,764 | Nov 5 | - | false |
| 86 | Machete | - | - | - | $31,366 | 3 | $31,366 | Oct 29 | Sony Pictures Releasing | false |
| 87 | Gnarr | - | - | - | $30,830 | 9 | $30,830 | Nov 12 | - | false |
| 88 | Paranormal Activity 2 | - | - | - | $30,827 | 3 | $31,752 | Dec 3 | United International Pictures | false |
| 89 | The Good Heart | - | - | - | $30,223 | 2 | $30,223 | Mar 5 | - | false |
| 90 | Nanny McPhee Returns | - | - | - | $29,775 | 4 | $29,775 | Mar 26 | United International Pictures | false |
| 91 | Up in the Air | - | - | - | $29,451 | 3 | $29,451 | Jan 22 | United International Pictures | false |
| 92 | From Paris with Love | - | - | - | $29,270 | 3 | $31,542 | Mar 5 | - | false |
| 93 | The Flight Before Christmas | - | - | - | $27,972 | 6 | $32,836 | Nov 26 | - | false |
| 94 | Cop Out | - | - | - | $27,566 | 2 | $27,566 | May 5 | Warner Bros. | false |
| 95 | Arthur 3: The War of the Two Worlds | - | - | - | $26,872 | 4 | $26,872 | Nov 12 | - | false |
| 96 | Easy A | - | - | - | $26,102 | 3 | $26,102 | Nov 12 | Sony Pictures Releasing | false |
| 97 | Brothers | - | - | - | $25,733 | 3 | $25,733 | Feb 19 | - | false |
| 98 | Furry Vengeance | - | - | - | $25,080 | 3 | $25,080 | Oct 8 | - | false |
| 99 | The Road | - | - | - | $24,870 | 1 | $24,870 | Jan 8 | - | false |
| 100 | Takers 2010 Re-release | - | - | - | $24,447 | 3 | $24,447 | Oct 22 | Sony Pictures Releasing | false |
| 101 | Solomon Kane | - | - | - | $23,757 | 2 | $23,757 | Sep 24 | - | false |
| 102 | Skyline | - | - | - | $23,171 | 5 | $23,171 | Nov 19 | - | false |
| 103 | StreetDance 2 | - | - | - | $22,352 | 3 | $22,352 | Jun 9 | - | false |
| 104 | Babies | - | - | - | $21,974 | 2 | $24,917 | Jul 21 | - | false |
| 105 | The American | - | - | - | $21,757 | 3 | $21,757 | Oct 8 | - | false |
| 106 | When in Rome | - | - | - | $21,377 | 3 | $21,377 | Mar 26 | Walt Disney Pictures | false |
| 107 | Happily N'ever After 2: Snow White: Another Bite at the Apple | - | - | - | $21,201 | 6 | $21,201 | Oct 29 | - | false |
| 108 | Crazy Heart | - | - | - | $20,680 | 1 | $20,680 | Apr 16 | 20th Century Fox International | false |
| 109 | Edge of Darkness | - | - | - | $20,575 | 3 | $54,073 | Feb 5 | - | false |
| 110 | Astro Boy | - | - | - | $19,978 | 7 | $21,892 | Apr 23 | - | false |
| 111 | Unstoppable | - | - | - | $19,430 | 3 | $19,430 | Nov 12 | 20th Century Fox International | false |
| 112 | The Losers | - | - | - | $19,276 | 2 | $21,566 | Jun 9 | Warner Bros. | false |
| 113 | Dear John | - | - | - | $19,234 | 3 | $22,088 | Mar 31 | - | false |
| 114 | Vampires Suck | - | - | - | $18,140 | 3 | $21,865 | Aug 18 | 20th Century Fox International | false |
| 115 | Amazon Jack 2010 Re-release | - | - | - | $17,935 | 4 | $17,935 | May 19 | - | false |
| 116 | Let Me In | - | - | - | $17,334 | 4 | $17,465 | Oct 29 | - | false |
| 117 | The Last Song | - | - | - | $17,313 | 3 | $19,568 | May 26 | Walt Disney Pictures | false |
| 118 | The Spy Next Door 2010 Re-release | - | - | - | $15,768 | 3 | $15,768 | Apr 16 | - | false |
| 119 | The Rebound | - | - | - | $15,657 | 2 | $15,657 | Feb 26 | - | false |
| 120 | You Will Meet a Tall Dark Stranger | - | - | - | $15,459 | 1 | $15,459 | Nov 5 | - | false |
| 121 | The Men Who Stare at Goats | - | - | - | $15,186 | 2 | $15,186 | Mar 26 | - | false |
| 122 | Whatever Works | - | - | - | $15,094 | 1 | $27,641 | Nov 27 | - | false |
| 123 | Messenger | - | - | - | $15,089 | 5 | $19,037 | Jul 7 | - | false |
| 124 | Legion | - | - | - | $14,071 | 3 | $14,071 | Mar 5 | Sony Pictures Releasing | false |
| 125 | Daybreakers | - | - | - | $13,394 | 2 | $13,394 | Mar 19 | - | false |
| 126 | A Nightmare on Elm Street | - | - | - | $13,214 | 4 | $31,612 | Jun 23 | Warner Bros. | false |
| 127 | Julie & Julia | - | - | - | $13,026 | 2 | $30,141 | Dec 4 | Sony Pictures Releasing | false |
| 128 | The Lovely Bones | - | - | - | $12,700 | 2 | $12,700 | Mar 19 | United International Pictures | false |
| 129 | The Crazies | - | - | - | $12,529 | 2 | $12,529 | Apr 16 | - | false |
| 130 | Centurion | - | - | - | $12,041 | 2 | $12,041 | May 26 | - | false |
| 131 | Toy Story 2 2009 Re-release | - | - | - | $10,713 | 3 | $10,713 | Feb 12 | Walt Disney Pictures | false |
| 132 | Remember Me | - | - | - | $10,451 | 2 | $10,451 | Sep 10 | - | false |
| 133 | Youth in Revolt | - | - | - | $10,252 | 2 | $11,802 | May 26 | - | false |
| 134 | Brooklyn's Finest 2010 Re-release | - | - | - | $9,782 | 2 | $9,782 | May 19 | - | false |
| 135 | The Human Centipede (First Sequence) | - | - | - | $9,632 | 1 | $9,632 | Aug 25 | - | false |
| 136 | Whip It | - | - | - | $9,207 | 2 | $9,207 | Jan 8 | - | false |
| 137 | 22 Bullets | - | - | - | $9,010 | 1 | $11,336 | Aug 4 | - | false |
| 138 | The Last Exorcism | - | - | - | $8,965 | 2 | $8,965 | Dec 10 | - | false |
| 139 | Old Dogs | - | - | - | $8,540 | 5 | $46,773 | Dec 11 | Walt Disney Pictures | false |
| 140 | The Imaginarium of Doctor Parnassus | - | - | - | $8,331 | 1 | $8,331 | Apr 16 | - | false |
| 141 | A Prophet | - | - | - | $7,977 | 1 | $7,977 | Apr 30 | Sony Pictures Releasing | false |
| 142 | The Ugly Duckling and Me! | - | - | - | $7,722 | 4 | $8,037 | Aug 6 | - | false |
| 143 | Með hangandi hendi | - | - | - | $6,775 | 1 | $6,775 | Oct 29 | - | false |
| 144 | Sorority Row | - | - | - | $6,559 | 2 | $18,945 | Dec 11 | - | false |
| 145 | Taking Woodstock | - | - | - | $6,274 | 1 | $6,274 | Jan 1 | - | false |
| 146 | Harry Brown | - | - | - | $5,530 | 1 | $5,530 | Jan 15 | - | false |
| 147 | The Twilight Saga: New Moon | - | - | - | $5,091 | 6 | $144,903 | Nov 25 | - | false |
| 148 | Where the Wild Things Are | - | - | - | $4,729 | 1 | $4,729 | Jan 29 | Warner Bros. | false |
| 149 | Agora | - | - | - | $4,498 | 1 | $4,498 | Nov 26 | - | false |
| 150 | Nine | - | - | - | $4,064 | 1 | $13,077 | Feb 5 | - | false |
| 151 | Earth | - | - | - | $3,654 | 1 | $3,654 | Mar 26 | - | false |
| 152 | Oceans | - | - | - | $3,186 | 1 | $3,408 | May 26 | - | false |
| 153 | A Christmas Carol | - | - | - | $3,039 | 11 | $148,749 | Nov 20 | Walt Disney Pictures | false |
| 154 | Ninja Assassin | - | - | - | $2,859 | 3 | $42,313 | Dec 4 | Warner Bros. | false |
| 155 | Invictus | - | - | - | $2,198 | 1 | $2,198 | Feb 19 | Warner Bros. | false |
| 156 | Arthur and the Revenge of Maltazard | - | - | - | $2,192 | 2 | $25,462 | Dec 4 | Warner Bros. | false |
| 157 | A Serious Man | - | - | - | $1,986 | 1 | $27,641 | Nov 20 | - | false |
| 158 | The Joneses | - | - | - | $1,861 | 12 | $5,279 | Dec 3 | - | false |
| 159 | Leap Year | - | - | - | $1,843 | 2 | $1,843 | Feb 26 | - | false |
| 160 | Stone | - | - | - | $1,540 | 1 | $1,540 | Nov 5 | - | false |
| 161 | The Kids Are All Right | - | - | - | $1,445 | 1 | $1,445 | Oct 29 | - | false |
| 162 | An Education | - | - | - | $824 | 1 | $4,238 | Feb 5 | - | false |
| 163 | The White Ribbon | - | - | - | $795 | 1 | $795 | Apr 23 | - | false |
| 164 | The Killer Inside Me | - | - | - | $476 | 1 | $476 | Dec 17 | - | false |
| 165 | Freakonomics | - | - | - | $454 | 1 | $454 | Nov 12 | - | false |
| 166 | Nowhere Boy | - | - | - | $411 | 1 | $411 | Apr 16 | - | false |
| 167 | R | - | - | - | $401 | 1 | $1,280 | Oct 4 | - | false |
| 168 | Fantastic Mr. Fox | - | - | - | $230 | 1 | $230 | Apr 16 | 20th Century Fox International | false |
| 169 | Catfish | - | - | - | $186 | 1 | $186 | Nov 12 | - | false |
| 170 | Armadillo | - | - | - | $154 | 1 | $154 | Nov 12 | - | false |
| 171 | Greenberg | - | - | - | $89 | 1 | $1,880 | Oct 15 | - | false |
| 172 | Enter the Void | - | - | - | $44 | 1 | $3,786 | Oct 8 | - | false |
