| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $1,883,812 | 8 | $2,369,317 | Dec 16 | 20th Century Fox International | false |
| 2 | Inception | - | - | - | $860,632 | 8 | $860,632 | Jul 17 | Warner Bros. | false |
| 3 | My Name Is Khan | - | - | - | $517,018 | 8 | $517,018 | Feb 17 | 20th Century Fox International | false |
| 4 | Clash of the Titans | - | - | - | $505,075 | 9 | $505,075 | Apr 14 | Warner Bros. | false |
| 5 | Alice in Wonderland | - | - | - | $503,454 | 4 | $503,454 | Mar 3 | Walt Disney Pictures | false |
| 6 | The Twilight Saga: Eclipse | - | - | - | $440,409 | 7 | $440,409 | Jul 7 | - | false |
| 7 | Toy Story 3 | - | - | - | $435,046 | 4 | $435,046 | Jun 16 | Walt Disney Pictures | false |
| 8 | Knight and Day 2010 Re-release | - | - | - | $425,760 | 7 | $447,547 | Jun 30 | 20th Century Fox International | false |
| 9 | Sherlock Holmes | - | - | - | $397,088 | 8 | $397,088 | Dec 30 | Warner Bros. | false |
| 10 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $380,121 | 10 | $403,632 | Nov 17 | Warner Bros. | false |
| 11 | Robin Hood | - | - | - | $379,598 | 10 | $379,598 | May 12 | United International Pictures | false |
| 12 | Prince of Persia: The Sands of Time | - | - | - | $345,819 | 10 | $345,819 | May 26 | Walt Disney Pictures | false |
| 13 | Step Up 3D | - | - | - | $333,928 | 8 | $333,928 | Sep 22 | - | false |
| 14 | Salt | - | - | - | $312,196 | 8 | $312,196 | Jul 21 | Sony Pictures Releasing | false |
| 15 | Iron Man 2 | - | - | - | $300,567 | 10 | $300,567 | Apr 29 | United International Pictures | false |
| 16 | The Book of Eli | - | - | - | $277,990 | 8 | $277,990 | Jan 27 | - | false |
| 17 | Shutter Island | - | - | - | $261,844 | 10 | $261,844 | Mar 10 | United International Pictures | false |
| 18 | Valentine's Day | - | - | - | $261,047 | 5 | $261,047 | Feb 10 | Warner Bros. | false |
| 19 | Shrek Forever After | - | - | - | $254,350 | 8 | $254,350 | Jun 30 | United International Pictures | false |
| 20 | Eat Pray Love | - | - | - | $245,414 | 6 | $245,414 | Oct 6 | Sony Pictures Releasing | false |
| 21 | The Bounty Hunter | - | - | - | $234,563 | 6 | $234,563 | Mar 24 | Sony Pictures Releasing | false |
| 22 | The Sorcerer's Apprentice | - | - | - | $213,654 | 8 | $213,654 | Sep 1 | Walt Disney Pictures | false |
| 23 | How to Train Your Dragon | - | - | - | $206,943 | 8 | $206,943 | Mar 31 | United International Pictures | false |
| 24 | Piranha 3D | - | - | - | $194,508 | 8 | $194,508 | Oct 6 | - | false |
| 25 | The Last Airbender | - | - | - | $192,167 | 8 | $192,167 | Jul 21 | United International Pictures | false |
| 26 | The Wolfman | - | - | - | $183,357 | 9 | $183,357 | Feb 24 | United International Pictures | false |
| 27 | From Paris with Love | - | - | - | $181,477 | 10 | $181,477 | Mar 10 | - | false |
| 28 | The Karate Kid | - | - | - | $179,558 | 5 | $179,558 | Jun 23 | Sony Pictures Releasing | false |
| 29 | Grown Ups | - | - | - | $158,395 | 5 | $158,395 | Aug 4 | Sony Pictures Releasing | false |
| 30 | Resident Evil: Afterlife | - | - | - | $156,129 | 10 | $156,129 | Oct 20 | - | false |
| 31 | A Nightmare on Elm Street | - | - | - | $149,076 | 9 | $149,076 | May 12 | Warner Bros. | false |
| 32 | Killers | - | - | - | $145,982 | 7 | $145,982 | Jun 2 | - | false |
| 33 | Despicable Me | - | - | - | $145,041 | 8 | $145,041 | Sep 15 | United International Pictures | false |
| 34 | Unstoppable | - | - | - | $144,756 | 8 | $172,819 | Nov 24 | 20th Century Fox International | false |
| 35 | RED | - | - | - | $140,701 | 9 | $147,519 | Nov 3 | - | false |
| 36 | 2012 | - | - | - | $126,736 | 8 | $1,101,387 | Nov 11 | Sony Pictures Releasing | false |
| 37 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $126,300 | 4 | $150,925 | Dec 23 | 20th Century Fox International | false |
| 38 | Due Date | - | - | - | $124,886 | 5 | $155,505 | Dec 1 | Warner Bros. | false |
| 39 | Old Dogs | - | - | - | $124,036 | 4 | $124,036 | Jan 6 | Walt Disney Pictures | false |
| 40 | The Town | - | - | - | $121,332 | 10 | $121,332 | Oct 27 | Warner Bros. | false |
| 41 | The Chronicles of Narnia: The Voyage of the Dawn Treader | - | - | - | $121,030 | 10 | $177,171 | Dec 8 | 20th Century Fox International | false |
| 42 | It's Complicated | - | - | - | $120,687 | 6 | $120,687 | Feb 3 | United International Pictures | false |
| 43 | Green Zone | - | - | - | $119,960 | 10 | $119,960 | Mar 17 | United International Pictures | false |
| 44 | The A-Team | - | - | - | $110,507 | 8 | $110,507 | Jun 9 | 20th Century Fox International | false |
| 45 | Remember Me | - | - | - | $109,369 | 5 | $109,369 | Mar 31 | - | false |
| 46 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $109,326 | 8 | $109,326 | Feb 10 | 20th Century Fox International | false |
| 47 | Date Night | - | - | - | $87,962 | 5 | $87,962 | May 5 | 20th Century Fox International | false |
| 48 | The Back-up Plan | - | - | - | $86,148 | 5 | $86,148 | May 12 | Sony Pictures Releasing | false |
| 49 | The Other Guys | - | - | - | $82,815 | 5 | $82,815 | Sep 15 | Sony Pictures Releasing | false |
| 50 | The Princess and the Frog | - | - | - | $78,838 | 3 | $78,838 | Dec 30 | Walt Disney Pictures | false |
| 51 | Wall Street: Money Never Sleeps | - | - | - | $78,785 | 4 | $78,785 | Sep 29 | 20th Century Fox International | false |
| 52 | Megamind | - | - | - | $77,434 | 9 | $131,336 | Nov 10 | United International Pictures | false |
| 53 | Tangled | - | - | - | $76,392 | 5 | $203,308 | Dec 15 | Walt Disney Pictures | false |
| 54 | Up in the Air | - | - | - | $76,195 | 5 | $76,195 | Feb 10 | United International Pictures | false |
| 55 | Nine | - | - | - | $74,434 | 4 | $74,434 | Jan 20 | - | false |
| 56 | The Social Network | - | - | - | $65,491 | 5 | $66,759 | Oct 27 | Sony Pictures Releasing | false |
| 57 | Devil | - | - | - | $63,709 | 9 | $63,709 | Nov 3 | United International Pictures | false |
| 58 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $63,244 | 6 | $63,244 | Sep 8 | Warner Bros. | false |
| 59 | Did You Hear About the Morgans? | - | - | - | $61,799 | 5 | $61,799 | Jan 27 | Sony Pictures Releasing | false |
| 60 | Triangle | - | - | - | $61,346 | 5 | $61,346 | Feb 3 | - | false |
| 61 | Predators | - | - | - | $59,082 | 5 | $59,082 | Aug 25 | 20th Century Fox International | false |
| 62 | She's Out of My League | - | - | - | $54,380 | 5 | $54,380 | Jul 7 | United International Pictures | false |
| 63 | When in Rome | - | - | - | $52,380 | 4 | $52,380 | Mar 17 | Walt Disney Pictures | false |
| 64 | Little Fockers | - | - | - | $52,132 | 9 | $164,770 | Dec 22 | United International Pictures | false |
| 65 | TRON: Legacy | - | - | - | $49,582 | 7 | $134,938 | Dec 22 | Walt Disney Pictures | false |
| 66 | The Collector | - | - | - | $48,196 | 6 | $48,196 | Oct 13 | - | false |
| 67 | The Last Song | - | - | - | $46,322 | 3 | $46,322 | Apr 21 | Walt Disney Pictures | false |
| 68 | Stag Night | - | - | - | $45,927 | 3 | $45,927 | Feb 24 | - | false |
| 69 | Dinner for Schmucks | - | - | - | $45,679 | 8 | $45,679 | Oct 13 | United International Pictures | false |
| 70 | The Children | - | - | - | $44,088 | 4 | $44,088 | Mar 10 | - | false |
| 71 | Paranormal Activity 2 | - | - | - | $42,126 | 6 | $46,001 | Dec 8 | United International Pictures | false |
| 72 | Charlie St. Cloud | - | - | - | $39,507 | 6 | $39,507 | Oct 20 | United International Pictures | false |
| 73 | Going the Distance | - | - | - | $37,718 | 4 | $37,718 | Sep 22 | Warner Bros. | false |
| 74 | Cop Out | - | - | - | $37,605 | 5 | $37,605 | May 19 | Warner Bros. | false |
| 75 | The American | - | - | - | $37,381 | 5 | $37,381 | Oct 13 | - | false |
| 76 | Ninja Assassin | - | - | - | $36,552 | 5 | $36,552 | Jan 6 | Warner Bros. | false |
| 77 | Splice 2010 Re-release | - | - | - | $35,241 | 8 | $35,241 | Sep 22 | - | false |
| 78 | The Twilight Saga: New Moon | - | - | - | $34,221 | 8 | $537,535 | Nov 25 | - | false |
| 79 | Pandorum | - | - | - | $33,447 | 5 | $33,447 | Mar 31 | - | false |
| 80 | Love Happens | - | - | - | $32,027 | 2 | $49,301 | Dec 23 | - | false |
| 81 | A Christmas Carol | - | - | - | $31,312 | 6 | $289,234 | Nov 18 | Walt Disney Pictures | false |
| 82 | The Box | - | - | - | $30,904 | 4 | $30,904 | Jan 13 | - | false |
| 83 | Daybreakers | - | - | - | $30,719 | 5 | $30,719 | Apr 21 | - | false |
| 84 | Faster | - | - | - | $30,699 | 5 | $30,699 | Dec 1 | Sony Pictures Releasing | false |
| 85 | The Losers | - | - | - | $29,075 | 5 | $29,075 | Sep 1 | Warner Bros. | false |
| 86 | The Lovely Bones | - | - | - | $28,688 | 8 | $28,688 | Mar 24 | United International Pictures | false |
| 87 | Brooklyn's Finest | - | - | - | $26,961 | 4 | $26,961 | May 5 | - | false |
| 88 | The Alphabet Killer | - | - | - | $26,854 | 3 | $26,854 | Apr 28 | - | false |
| 89 | Nanny McPhee Returns | - | - | - | $25,428 | 6 | $25,428 | Jun 2 | United International Pictures | false |
| 90 | Repo Men | - | - | - | $23,561 | 6 | $23,561 | May 26 | United International Pictures | false |
| 91 | High Lane | - | - | - | $22,200 | 5 | $22,200 | Jan 27 | - | false |
| 92 | Letters to Juliet | - | - | - | $22,143 | 6 | $22,143 | Sep 29 | - | false |
| 93 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $21,432 | 7 | $21,432 | Oct 27 | Warner Bros. | false |
| 94 | New York | - | - | - | $21,201 | 5 | $21,201 | Apr 28 | - | false |
| 95 | The Tournament | - | - | - | $19,088 | 5 | $19,088 | Mar 3 | - | false |
| 96 | Couples Retreat | - | - | - | $17,484 | 6 | $98,269 | Nov 25 | United International Pictures | false |
| 97 | Cirque du Freak: The Vampire's Assistant | - | - | - | $17,087 | 5 | $42,000 | Dec 9 | United International Pictures | false |
| 98 | Easy A | - | - | - | $14,919 | 3 | $14,919 | Nov 24 | Sony Pictures Releasing | false |
| 99 | Case 39 | - | - | - | $14,722 | 8 | $94,084 | Nov 25 | United International Pictures | false |
| 100 | Furry Vengeance | - | - | - | $11,640 | 2 | $11,640 | Oct 13 | - | false |
| 101 | How to Lose Friends & Alienate People | - | - | - | $10,515 | 5 | $10,515 | Jan 13 | - | false |
| 102 | You Again | - | - | - | $10,332 | 3 | $10,332 | Oct 20 | Walt Disney Pictures | false |
| 103 | Scott Pilgrim vs. the World | - | - | - | $9,591 | 3 | $9,591 | Nov 24 | United International Pictures | false |
| 104 | Takers 2010 Re-release | - | - | - | $9,478 | 2 | $9,478 | Nov 3 | Sony Pictures Releasing | false |
| 105 | The Stepfather | - | - | - | $9,082 | 5 | $20,563 | Dec 23 | Sony Pictures Releasing | false |
| 106 | Armored | - | - | - | $8,115 | 3 | $8,115 | Jan 20 | Sony Pictures Releasing | false |
| 107 | Franklyn | - | - | - | $7,773 | 3 | $7,773 | Jan 27 | - | false |
| 108 | Machete | - | - | - | $6,980 | 3 | $7,444 | Dec 8 | Sony Pictures Releasing | false |
| 109 | The Joneses | - | - | - | $5,925 | 2 | $6,339 | Dec 15 | - | false |
| 110 | The Ugly Duckling and Me! | - | - | - | $5,631 | 2 | $5,631 | Feb 3 | - | false |
| 111 | Astro Boy | - | - | - | $5,626 | 3 | $5,626 | Apr 14 | - | false |
| 112 | Halloween II | - | - | - | $3,749 | 5 | $49,397 | Oct 28 | - | false |
| 113 | Management | - | - | - | $2,709 | 3 | $40,535 | Oct 28 | - | false |
| 114 | Orphan | - | - | - | $1,159 | 5 | $119,269 | Sep 30 | Warner Bros. | false |
| 115 | Surrogates | - | - | - | $852 | 6 | $130,897 | Oct 7 | Walt Disney Pictures | false |
| 116 | Arthur and the Revenge of Maltazard | - | - | - | $847 | 2 | $847 | Jan 27 | - | false |
| 117 | The Ugly Truth | - | - | - | $742 | 6 | $206,681 | Sep 23 | Sony Pictures Releasing | false |
| 118 | Cloudy with a Chance of Meatballs | - | - | - | $18 | 3 | $43,779 | Sep 16 | Sony Pictures Releasing | false |
