| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $1,453,509 | 102 | $1,453,509 | May 15 | Sony Pictures Releasing | false |
| 2 | Terminator Salvation | - | - | - | $1,024,758 | 100 | $1,024,758 | Jun 4 | Sony Pictures Releasing | false |
| 3 | Ice Age: Dawn of the Dinosaurs | - | - | - | $646,009 | 37 | $646,009 | Jul 3 | 20th Century Fox International | false |
| 4 | Transformers: Revenge of the Fallen | - | - | - | $506,977 | 32 | $506,977 | Jun 23 | United International Pictures | false |
| 5 | The Taking of Pelham 123 | - | - | - | $486,048 | 70 | $532,819 | Aug 28 | Sony Pictures Releasing | false |
| 6 | Harry Potter and the Half-Blood Prince | - | - | - | $407,820 | 32 | $407,820 | Jul 15 | Warner Bros. | false |
| 7 | The Ugly Truth | - | - | - | $363,239 | 30 | $371,442 | Sep 18 | Sony Pictures Releasing | false |
| 8 | Fast & Furious | - | - | - | $345,890 | 25 | $345,890 | Apr 3 | United International Pictures | false |
| 9 | Night at the Museum: Battle of the Smithsonian | - | - | - | $307,697 | 27 | $307,697 | May 21 | 20th Century Fox International | false |
| 10 | G-Force | - | - | - | $298,217 | 23 | $298,217 | Jul 31 | Walt Disney Pictures | false |
| 11 | Paul Blart: Mall Cop | - | - | - | $293,678 | 27 | $300,180 | Apr 9 | Sony Pictures Releasing | false |
| 12 | Up | - | - | - | $265,939 | 26 | $300,479 | Jun 12 | Walt Disney Pictures | false |
| 13 | G.I. Joe: The Rise of Cobra | - | - | - | $254,451 | 22 | $254,451 | Aug 7 | United International Pictures | false |
| 14 | X-Men Origins: Wolverine | - | - | - | $210,692 | 26 | $249,039 | Apr 30 | 20th Century Fox International | false |
| 15 | Underworld: Rise of the Lycans | - | - | - | $202,312 | 30 | $310,431 | Mar 27 | Sony Pictures Releasing | false |
| 16 | Monsters vs. Aliens | - | - | - | $196,497 | 25 | $196,497 | Apr 3 | United International Pictures | false |
| 17 | The Proposal | - | - | - | $144,995 | 15 | $144,995 | Jul 10 | Walt Disney Pictures | false |
| 18 | Race to Witch Mountain | - | - | - | $132,877 | 17 | $132,877 | Apr 17 | Walt Disney Pictures | false |
| 19 | Doubt | - | - | - | $115,322 | 6 | $118,185 | May 15 | Walt Disney Pictures | false |
| 20 | Orphan | - | - | - | $113,875 | 15 | $113,875 | Aug 7 | Warner Bros. | false |
| 21 | Ghosts of Girlfriends Past | - | - | - | $103,118 | 13 | $103,118 | May 22 | Warner Bros. | false |
| 22 | Drag Me to Hell | - | - | - | $92,739 | 15 | $92,739 | Sep 11 | United International Pictures | false |
| 23 | The Unborn | - | - | - | $89,568 | 15 | $89,568 | May 8 | United International Pictures | false |
| 24 | 17 Again | - | - | - | $81,411 | 14 | $81,411 | Apr 24 | Warner Bros. | false |
| 25 | The Hangover | - | - | - | $71,200 | 13 | $203,027 | Aug 21 | Warner Bros. | false |
| 26 | The Uninvited | - | - | - | $69,393 | 11 | $69,393 | Jul 24 | United International Pictures | false |
| 27 | District 9 | - | - | - | $67,682 | 30 | $71,631 | Oct 2 | Sony Pictures Releasing | false |
| 28 | Knowing | - | - | - | $62,620 | 12 | $62,620 | May 8 | - | false |
| 29 | Hannah Montana: The Movie | - | - | - | $57,880 | 12 | $65,081 | May 15 | Walt Disney Pictures | false |
| 30 | Star Trek | - | - | - | $53,814 | 12 | $53,814 | May 8 | United International Pictures | false |
| 31 | Tinker Bell and the Lost Treasure | - | - | - | $52,161 | 16 | $52,161 | Sep 4 | Walt Disney Pictures | false |
| 32 | Land of the Lost | - | - | - | $49,959 | 13 | $58,255 | Sep 18 | United International Pictures | false |
| 33 | State of Play | - | - | - | $49,823 | 7 | $49,823 | Jul 24 | United International Pictures | false |
| 34 | Duplicity | - | - | - | $47,118 | 11 | $47,118 | May 29 | United International Pictures | false |
| 35 | Dragonball Evolution | - | - | - | $45,717 | 21 | $63,749 | Apr 9 | 20th Century Fox International | false |
| 36 | My Sister's Keeper | - | - | - | $40,213 | 6 | $40,213 | Jul 31 | Warner Bros. | false |
| 37 | Aliens in the Attic | - | - | - | $38,549 | 14 | $62,482 | Aug 28 | 20th Century Fox International | false |
| 38 | The Final Destination | - | - | - | $38,316 | 8 | $38,316 | Sep 25 | Warner Bros. | false |
| 39 | Slumdog Millionaire | - | - | - | $37,983 | 4 | $96,509 | Mar 20 | - | false |
| 40 | The Accidental Husband | - | - | - | $36,126 | 13 | $77,395 | Aug 28 | Walt Disney Pictures | false |
| 41 | The Reader | - | - | - | $35,148 | 8 | $35,148 | Jun 19 | - | false |
| 42 | The Last House on the Left | - | - | - | $34,072 | 12 | $34,072 | Jul 10 | United International Pictures | false |
| 43 | Confessions of a Shopaholic | - | - | - | $31,134 | 14 | $60,521 | Mar 27 | Walt Disney Pictures | false |
| 44 | Push | - | - | - | $29,324 | 11 | $29,324 | Jun 19 | - | false |
| 45 | The Time Traveler's Wife | - | - | - | $25,637 | 7 | $25,637 | Sep 11 | Warner Bros. | false |
| 46 | Earth | - | - | - | $24,513 | 4 | $24,513 | Apr 22 | Walt Disney Pictures | false |
| 47 | 88 Minutes | - | - | - | $19,882 | 8 | $19,882 | Sep 11 | - | false |
| 48 | The Boy in the Striped Pajamas | - | - | - | $16,845 | 5 | $36,939 | Mar 27 | Walt Disney Pictures | false |
| 49 | Gran Torino | - | - | - | $11,299 | 5 | $52,773 | Mar 20 | Warner Bros. | false |
| 50 | The Haunting in Connecticut | - | - | - | $11,134 | 9 | $14,389 | Sep 18 | - | false |
| 51 | Seven Pounds | - | - | - | $10,943 | 8 | $408,943 | Jan 16 | Sony Pictures Releasing | false |
| 52 | The Marsh | - | - | - | $10,914 | 4 | $14,200 | Apr 10 | - | false |
| 53 | The Bank Job | - | - | - | $10,841 | 5 | $15,354 | Sep 18 | - | false |
| 54 | Talento de barrio | - | - | - | $10,754 | 8 | $13,704 | Jun 12 | - | false |
| 55 | 12 Rounds | - | - | - | $10,721 | 8 | $14,760 | Sep 18 | 20th Century Fox International | false |
| 56 | The Flock | - | - | - | $10,098 | 6 | $10,098 | Apr 30 | - | false |
| 57 | Rudo y Cursi | - | - | - | $10,075 | 11 | $10,729 | May 1 | United International Pictures | false |
| 58 | Milk | - | - | - | $9,530 | 8 | $9,530 | May 8 | United International Pictures | false |
| 59 | Fly Me to the Moon 3D | - | - | - | $9,512 | 33 | $9,512 | Sep 4 | - | false |
| 60 | Shorts | - | - | - | $9,390 | 8 | $82,145 | Aug 14 | Warner Bros. | false |
| 61 | The Mist | - | - | - | $8,928 | 8 | $8,928 | Apr 24 | - | false |
| 62 | Vicky Cristina Barcelona | - | - | - | $8,878 | 3 | $8,878 | Jul 24 | - | false |
| 63 | Transporter 3 | - | - | - | $7,824 | 6 | $7,824 | Sep 25 | - | false |
| 64 | Funny Games | - | - | - | $7,807 | 6 | $7,807 | Apr 17 | - | false |
| 65 | Public Enemies | - | - | - | $6,379 | 3 | $83,141 | Aug 14 | United International Pictures | false |
| 66 | My Bloody Valentine | - | - | - | $6,169 | 2 | $53,412 | Aug 14 | - | false |
| 67 | Che: Part One | - | - | - | $4,235 | 8 | $4,235 | Sep 25 | - | false |
| 68 | Marley & Me | - | - | - | $3,431 | 12 | $174,353 | Jan 1 | 20th Century Fox International | false |
| 69 | Jonas Brothers: The 3D Concert Experience | - | - | - | $2,524 | 4 | $33,248 | Mar 20 | Walt Disney Pictures | false |
| 70 | Flawless | - | - | - | $2,266 | 2 | $40,656 | Mar 13 | - | false |
| 71 | The Page Turner 2009 Re-release | - | - | - | $825 | 1 | $825 | Sep 4 | - | false |
| 72 | The Hunting Party | - | - | - | $392 | 2 | $22,158 | Mar 13 | - | false |
| 73 | The Curious Case of Benjamin Button | - | - | - | $224 | 1 | $652,328 | Jan 23 | Warner Bros. | false |
| 74 | Free Style | - | - | - | $171 | 2 | $45,288 | Feb 13 | 20th Century Fox International | false |
| 75 | Hotel for Dogs | - | - | - | $164 | 1 | $105,401 | Jan 23 | United International Pictures | false |
| 76 | Wild Child | - | - | - | $115 | 1 | $35,075 | Mar 13 | United International Pictures | false |
| 77 | Coraline | - | - | - | $113 | 2 | $52,085 | Feb 27 | United International Pictures | false |
| 78 | Friday the 13th | - | - | - | $74 | 1 | $73,679 | Feb 13 | United International Pictures | false |
| 79 | Watchmen | - | - | - | $54 | 2 | $84,100 | Mar 6 | United International Pictures | false |
