| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | 2012 | - | - | - | $6,631,338 | 75 | $6,640,261 | Nov 13 | Sony Pictures Releasing | false |
| 2 | Transformers: Revenge of the Fallen | - | - | - | $4,056,692 | 75 | $4,469,608 | Jun 24 | United International Pictures | false |
| 3 | Harry Potter and the Half-Blood Prince | - | - | - | $3,516,860 | 75 | $3,749,876 | Jul 16 | Warner Bros. | false |
| 4 | Avatar | - | - | - | $3,466,633 | 87 | $5,809,653 | Dec 17 | 20th Century Fox International | false |
| 5 | G.I. Joe: The Rise of Cobra | - | - | - | $2,221,932 | 40 | $2,221,932 | Aug 7 | United International Pictures | false |
| 6 | Terminator Salvation | - | - | - | $1,995,050 | 70 | $1,995,050 | May 27 | Sony Pictures Releasing | false |
| 7 | Ice Age: Dawn of the Dinosaurs | - | - | - | $1,938,233 | 48 | $2,113,727 | Jul 1 | 20th Century Fox International | false |
| 8 | Angels & Demons | - | - | - | $1,826,798 | 50 | $1,826,798 | May 13 | Sony Pictures Releasing | false |
| 9 | Ninja Assassin | - | - | - | $1,584,794 | 50 | $1,862,728 | Nov 26 | Warner Bros. | false |
| 10 | Night at the Museum: Battle of the Smithsonian | - | - | - | $1,538,133 | 50 | $1,882,185 | May 20 | 20th Century Fox International | false |
| 11 | Up | - | - | - | $1,479,223 | 44 | $1,479,223 | Jul 29 | Walt Disney Pictures | false |
| 12 | X-Men Origins: Wolverine | - | - | - | $1,474,812 | 50 | $1,642,659 | Apr 29 | 20th Century Fox International | false |
| 13 | G-Force | - | - | - | $1,276,028 | 33 | $1,380,947 | Sep 16 | Walt Disney Pictures | false |
| 14 | Star Trek | - | - | - | $1,057,869 | 25 | $1,057,869 | Jun 9 | United International Pictures | false |
| 15 | Surrogates | - | - | - | $914,889 | 30 | $914,889 | Sep 30 | Walt Disney Pictures | false |
| 16 | Fast & Furious | - | - | - | $900,129 | 40 | $2,291,140 | Apr 3 | United International Pictures | false |
| 17 | The Proposal | - | - | - | $890,745 | 30 | $890,745 | Aug 19 | Walt Disney Pictures | false |
| 18 | The Ugly Truth | - | - | - | $874,651 | 30 | $639,473 | Oct 7 | Sony Pictures Releasing | false |
| 19 | This Is It | - | - | - | $827,814 | 25 | $827,814 | Oct 28 | Sony Pictures Releasing | false |
| 20 | Public Enemies | - | - | - | $735,019 | 30 | $735,019 | Jul 22 | United International Pictures | false |
| 21 | Cloudy with a Chance of Meatballs | - | - | - | $650,135 | 41 | $667,890 | Oct 14 | Sony Pictures Releasing | false |
| 22 | Orphan | - | - | - | $614,532 | 31 | $614,532 | Aug 14 | Warner Bros. | false |
| 23 | Inglourious Basterds | - | - | - | $568,710 | 24 | $568,710 | Oct 16 | United International Pictures | false |
| 24 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $526,621 | 30 | $1,117,869 | Dec 23 | 20th Century Fox International | false |
| 25 | A Christmas Carol | - | - | - | $484,021 | 56 | $484,021 | Nov 18 | Walt Disney Pictures | false |
| 26 | Race to Witch Mountain | - | - | - | $456,430 | 30 | $512,811 | Apr 15 | Walt Disney Pictures | false |
| 27 | Old Dogs | - | - | - | $398,277 | 30 | $437,868 | Dec 2 | Walt Disney Pictures | false |
| 28 | Monsters vs. Aliens | - | - | - | $383,823 | 30 | $804,189 | Apr 8 | United International Pictures | false |
| 29 | The Taking of Pelham 123 | - | - | - | $378,236 | 25 | $505,763 | Aug 12 | Sony Pictures Releasing | false |
| 30 | Watchmen | - | - | - | $351,839 | 22 | $351,839 | Apr 22 | United International Pictures | false |
| 31 | The Hangover | - | - | - | $226,871 | 15 | $249,579 | Aug 26 | Warner Bros. | false |
| 32 | Sherlock Holmes | - | - | - | $214,275 | 45 | $2,163,216 | Dec 30 | Warner Bros. | false |
| 33 | Dragonball Evolution | - | - | - | $208,379 | 17 | $1,251,541 | Mar 25 | 20th Century Fox International | false |
| 34 | Zombieland | - | - | - | $175,157 | 30 | $231,555 | Dec 9 | Sony Pictures Releasing | false |
| 35 | Whiteout | - | - | - | $173,993 | 26 | $173,993 | Oct 9 | Warner Bros. | false |
| 36 | The International | - | - | - | $161,544 | 23 | $170,726 | Apr 17 | Sony Pictures Releasing | false |
| 37 | Aliens in the Attic | - | - | - | $155,726 | 30 | $190,963 | Aug 5 | 20th Century Fox International | false |
| 38 | Hannah Montana: The Movie | - | - | - | $154,566 | 25 | $154,566 | Jul 8 | Walt Disney Pictures | false |
| 39 | Land of the Lost | - | - | - | $122,272 | 15 | $122,272 | Aug 21 | United International Pictures | false |
| 40 | Yes Man | - | - | - | $91,032 | 4 | $704,041 | Jan 7 | Warner Bros. | false |
| 41 | Valkyrie | - | - | - | $90,490 | 8 | $494,106 | Feb 11 | 20th Century Fox International | false |
| 42 | Underworld: Rise of the Lycans | - | - | - | $71,418 | 7 | $672,678 | Feb 4 | Sony Pictures Releasing | false |
| 43 | I Love You, Beth Cooper | - | - | - | $58,378 | 15 | $58,378 | Jul 31 | 20th Century Fox International | false |
| 44 | Australia | - | - | - | $26,551 | 5 | $256,655 | Dec 24 | 20th Century Fox International | false |
| 45 | Confessions of a Shopaholic | - | - | - | $1,753 | 3 | $483,720 | Mar 11 | Walt Disney Pictures | false |
