| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Sex and the City | - | - | - | $396,390 | 5 | $396,390 | Jun 6 | - | false |
| 2 | Quantum of Solace | - | - | - | $354,360 | 6 | $357,298 | Nov 7 | - | false |
| 3 | Horton Hears a Who! | - | - | - | $305,929 | 8 | $305,929 | Mar 14 | - | false |
| 4 | Mamma Mia! | - | - | - | $282,257 | 4 | $371,601 | Jul 18 | - | false |
| 5 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $276,765 | 5 | $276,765 | May 22 | - | false |
| 6 | December Heat | - | - | - | $260,220 | 6 | $260,220 | Oct 17 | - | false |
| 7 | Kung Fu Panda | - | - | - | $256,412 | 8 | $256,412 | Jun 6 | - | false |
| 8 | Fly Me to the Moon 3D | - | - | - | $222,617 | 3 | $222,617 | Oct 24 | - | false |
| 9 | Hancock | - | - | - | $218,730 | 4 | $252,185 | Jul 2 | - | false |
| 10 | Wanted | - | - | - | $200,888 | 4 | $212,791 | Jun 27 | - | false |
| 11 | The Dark Knight | - | - | - | $196,792 | 4 | $239,130 | Jul 25 | - | false |
| 12 | Journey to the Center of the Earth | - | - | - | $196,156 | 2 | $231,938 | Dec 5 | - | false |
| 13 | WALL·E | - | - | - | $192,150 | 9 | $246,032 | Aug 15 | - | false |
| 14 | What Happens in Vegas | - | - | - | $186,816 | 3 | $186,816 | May 9 | - | false |
| 15 | Madagascar: Escape 2 Africa | - | - | - | $170,688 | 9 | $255,037 | Dec 12 | - | false |
| 16 | The Mummy: Tomb of the Dragon Emperor | - | - | - | $160,514 | 4 | $209,527 | Aug 8 | - | false |
| 17 | Jumper | - | - | - | $157,099 | 4 | $157,099 | Feb 15 | - | false |
| 18 | 10,000 BC | - | - | - | $153,429 | 4 | $153,429 | Mar 21 | - | false |
| 19 | National Treasure: Book of Secrets | - | - | - | $111,798 | 6 | $264,359 | Dec 21 | - | false |
| 20 | I Am Legend | - | - | - | $102,995 | 3 | $102,995 | Jan 4 | Warner Bros. | false |
| 21 | Tropic Thunder | - | - | - | $101,713 | 4 | $101,713 | Aug 22 | - | false |
| 22 | The Chronicles of Narnia: Prince Caspian | - | - | - | $101,117 | 5 | $101,117 | Jun 18 | - | false |
| 23 | 27 Dresses | - | - | - | $96,217 | 2 | $96,217 | Feb 22 | - | false |
| 24 | Step Up 2: The Streets | - | - | - | $90,180 | 1 | $90,180 | Feb 29 | - | false |
| 25 | You Don't Mess with the Zohan | - | - | - | $89,263 | 3 | $89,263 | Aug 1 | - | false |
| 26 | Fool's Gold | - | - | - | $86,561 | 3 | $86,561 | Apr 4 | - | false |
| 27 | Max Payne | - | - | - | $84,493 | 3 | $94,240 | Oct 17 | - | false |
| 28 | The Happening | - | - | - | $84,274 | 4 | $84,274 | Jun 13 | - | false |
| 29 | Iron Man | - | - | - | $83,069 | 3 | $83,069 | May 1 | - | false |
| 30 | The Best Movie | - | - | - | $78,690 | 5 | $78,690 | Jan 25 | - | false |
| 31 | No Country for Old Men | - | - | - | $76,828 | 2 | $76,828 | Feb 8 | - | false |
| 32 | Atonement | - | - | - | $75,528 | 2 | $75,528 | Jan 11 | - | false |
| 33 | Saw V | - | - | - | $75,256 | 3 | $75,256 | Oct 31 | - | false |
| 34 | Cloverfield | - | - | - | $74,766 | 4 | $74,766 | Jan 25 | - | false |
| 35 | Pineapple Express | - | - | - | $74,086 | 3 | $74,086 | Oct 3 | - | false |
| 36 | Get Smart | - | - | - | $73,131 | 3 | $73,131 | Jul 11 | - | false |
| 37 | The X Files: I Want to Believe | - | - | - | $72,605 | 4 | $95,136 | Aug 1 | - | false |
| 38 | Mirrors | - | - | - | $70,404 | 3 | $81,569 | Sep 19 | - | false |
| 39 | The Day the Earth Stood Still | - | - | - | $68,623 | 5 | $85,894 | Dec 12 | - | false |
| 40 | Death Race | - | - | - | $67,004 | 4 | $75,506 | Sep 19 | - | false |
| 41 | Burn After Reading | - | - | - | $65,441 | 3 | $74,323 | Oct 10 | - | false |
| 42 | The House Bunny | - | - | - | $64,435 | 2 | $64,435 | Oct 17 | - | false |
| 43 | Sweeney Todd: The Demon Barber of Fleet Street | - | - | - | $62,705 | 2 | $62,705 | Feb 15 | - | false |
| 44 | Definitely, Maybe | - | - | - | $61,853 | 2 | $61,853 | Mar 7 | - | false |
| 45 | Aliens vs. Predator: Requiem | - | - | - | $58,513 | 3 | $87,575 | Dec 28 | - | false |
| 46 | Step Brothers | - | - | - | $57,837 | 3 | $57,837 | Sep 12 | - | false |
| 47 | Transporter 3 | - | - | - | $56,823 | 3 | $64,179 | Dec 19 | - | false |
| 48 | The Irony of Fate 2 | - | - | - | $56,454 | 6 | $257,311 | Dec 28 | - | false |
| 49 | Rambo | - | - | - | $54,832 | 2 | $54,832 | Feb 1 | - | false |
| 50 | Forgetting Sarah Marshall | - | - | - | $52,879 | 2 | $52,879 | Apr 25 | - | false |
| 51 | Body of Lies | - | - | - | $52,873 | 4 | $52,873 | Nov 28 | - | false |
| 52 | Street Kings | - | - | - | $50,220 | 3 | $50,220 | Apr 11 | - | false |
| 53 | High School Musical 3: Senior Year | - | - | - | $49,360 | 3 | $49,360 | Oct 24 | - | false |
| 54 | Disaster Movie | - | - | - | $48,727 | 3 | $62,050 | Aug 29 | - | false |
| 55 | Made of Honor | - | - | - | $45,289 | 2 | $49,095 | May 1 | - | false |
| 56 | 21 | - | - | - | $44,194 | 1 | $44,194 | Apr 18 | - | false |
| 57 | Righteous Kill | - | - | - | $43,433 | 2 | $52,329 | Sep 26 | - | false |
| 58 | The Bucket List | - | - | - | $42,893 | 1 | $42,893 | Apr 18 | - | false |
| 59 | The Ruins | - | - | - | $40,835 | 1 | $40,835 | Apr 18 | - | false |
| 60 | Eagle Eye | - | - | - | $38,945 | 4 | $47,024 | Oct 10 | - | false |
| 61 | Prom Night | - | - | - | $38,428 | 1 | $38,428 | May 30 | - | false |
| 62 | Nights in Rodanthe | - | - | - | $38,362 | 3 | $38,362 | Nov 14 | - | false |
| 63 | The Other Boleyn Girl | - | - | - | $37,545 | 1 | $37,545 | Feb 29 | - | false |
| 64 | U2 3D | - | - | - | $37,024 | 2 | $37,024 | Oct 24 | - | false |
| 65 | Bee Movie | - | - | - | $35,501 | 3 | $75,942 | Dec 14 | - | false |
| 66 | Meet the Spartans | - | - | - | $32,726 | 1 | $32,726 | Feb 1 | - | false |
| 67 | Four Christmases | - | - | - | $31,346 | 3 | $42,746 | Dec 19 | - | false |
| 68 | Meet Dave | - | - | - | $30,806 | 3 | $38,956 | Jul 18 | - | false |
| 69 | Quarantine | - | - | - | $30,702 | 2 | $30,702 | Nov 21 | - | false |
| 70 | Vantage Point | - | - | - | $30,593 | 2 | $30,593 | Mar 7 | - | false |
| 71 | Twilight | - | - | - | $29,797 | - | $61,400 | Nov 28 | - | false |
| 72 | Beverly Hills Chihuahua | - | - | - | $29,525 | 4 | $29,525 | Nov 21 | - | false |
| 73 | Australia | - | - | - | $29,032 | 5 | $101,258 | Dec 26 | - | false |
| 74 | Hellboy II: The Golden Army | - | - | - | $28,256 | 3 | $35,759 | Sep 5 | - | false |
| 75 | One Missed Call | - | - | - | $27,591 | 1 | $27,591 | Feb 8 | - | false |
| 76 | The Eye | - | - | - | $27,080 | 1 | $27,080 | Mar 21 | - | false |
| 77 | The Water Horse | - | - | - | $26,238 | 1 | $26,238 | Feb 29 | - | false |
| 78 | Michael Clayton | - | - | - | $25,633 | 1 | $25,633 | Jan 25 | - | false |
| 79 | We Own the Night | - | - | - | $25,598 | 1 | $25,598 | Jan 18 | - | false |
| 80 | Shutter | - | - | - | $24,916 | 1 | $24,916 | Apr 25 | - | false |
| 81 | The Incredible Hulk | - | - | - | $24,822 | 3 | $28,037 | Jun 13 | - | false |
| 82 | Charlie Wilson's War | - | - | - | $24,452 | 1 | $24,452 | Feb 1 | - | false |
| 83 | The Golden Compass | - | - | - | $24,151 | 3 | $96,192 | Dec 14 | - | false |
| 84 | The Darjeeling Limited | - | - | - | $23,066 | 1 | $23,066 | Feb 8 | - | false |
| 85 | There Will Be Blood | - | - | - | $22,863 | 1 | $22,863 | Feb 15 | - | false |
| 86 | Pathology | - | - | - | $22,120 | 1 | $22,120 | Jul 2 | - | false |
| 87 | The Midnight Meat Train | - | - | - | $21,980 | 1 | $29,363 | Aug 15 | - | false |
| 88 | The Game Plan | - | - | - | $21,705 | 1 | $21,705 | Mar 21 | - | false |
| 89 | Bedtime Stories | - | - | - | $19,055 | 4 | $44,182 | Dec 26 | - | false |
| 90 | The Spiderwick Chronicles | - | - | - | $18,824 | 1 | $18,824 | Mar 14 | - | false |
| 91 | Drillbit Taylor | - | - | - | $18,696 | 1 | $18,696 | Mar 28 | - | false |
| 92 | In Bruges | - | - | - | $18,182 | 1 | $22,073 | Sep 5 | - | false |
| 93 | Leatherheads | - | - | - | $16,834 | 1 | $16,834 | Apr 11 | - | false |
| 94 | Untraceable | - | - | - | $16,826 | 1 | $16,826 | Apr 4 | - | false |
| 95 | Enchanted | - | - | - | $16,426 | 4 | $113,492 | Nov 30 | - | false |
| 96 | Sex Drive | - | - | - | $15,332 | 1 | $18,700 | Dec 26 | - | false |
| 97 | Bangkok Dangerous | - | - | - | $15,248 | 1 | $15,248 | Oct 17 | - | false |
| 98 | The Strangers | - | - | - | $15,224 | 1 | $18,787 | Jul 25 | - | false |
| 99 | Never Back Down | - | - | - | $13,306 | 1 | $13,306 | May 30 | - | false |
| 100 | Speed Racer | - | - | - | $13,196 | 3 | $13,196 | May 16 | - | false |
| 101 | Star Wars: The Clone Wars | - | - | - | $12,587 | 2 | $14,000 | Oct 3 | - | false |
| 102 | Baby Mama | - | - | - | $11,736 | 1 | $11,736 | May 16 | - | false |
| 103 | Deception | - | - | - | $10,565 | 2 | $10,565 | May 9 | - | false |
| 104 | Street Racer | - | - | - | $10,559 | 2 | $23,725 | Mar 7 | - | false |
| 105 | The Rocker | - | - | - | $8,258 | 1 | $12,272 | Oct 31 | - | false |
| 106 | The Forbidden Kingdom | - | - | - | $6,973 | 1 | $6,973 | Jul 11 | - | false |
| 107 | Nim's Island | - | - | - | $6,807 | 1 | $6,807 | Jun 27 | - | false |
| 108 | Redbelt | - | - | - | $5,609 | 1 | $5,609 | Jul 18 | - | false |
