| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Suicide Squad | $35,134,747 | - | 4,002 | - | $8,779 | $35,134,747 | 1 | Warner Bros. | true | false |
| 2 | 1 | Jungle Cruise | $23,518,100 | -52.6% | 4,310 | - | $5,456 | $73,142,554 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 3 | 3 | Old | $6,174,495 | -41.4% | 3,138 | -241 | $1,967 | $40,557,640 | 3 | Universal Pictures | false | false |
| 4 | 4 | Black Widow | $5,847,747 | -39.8% | 3,100 | -260 | $1,886 | $176,199,531 | 5 | Walt Disney Studios Motion Pictures | false | false |
| 5 | 6 | Stillwater | $4,102,625 | -42.5% | 2,611 | +80 | $1,571 | $11,242,695 | 2 | Focus Features | false | false |
| 6 | 5 | The Green Knight | $4,003,128 | -58.2% | 2,798 | +8 | $1,430 | $13,574,855 | 2 | A24 | false | false |
| 7 | 2 | Space Jam: A New Legacy | $3,796,957 | -67.8% | 2,869 | -632 | $1,323 | $66,967,738 | 4 | Warner Bros. | false | false |
| 8 | 7 | Snake Eyes | $2,527,233 | -58.5% | 2,080 | -1,460 | $1,215 | $26,904,205 | 3 | Paramount Pictures | false | false |
| 9 | 9 | Escape Room: Tournament of Champions | $2,032,468 | -40.9% | 1,303 | -783 | $1,559 | $23,822,838 | 4 | Sony Pictures Releasing | false | false |
| 10 | 8 | F9: The Fast Saga | $1,744,920 | -55.4% | 1,715 | -633 | $1,017 | $171,549,065 | 7 | Universal Pictures | false | false |
| 11 | 10 | The Boss Baby: Family Business | $1,215,580 | -46.1% | 1,405 | -460 | $865 | $55,636,295 | 6 | Universal Pictures | false | false |
| 12 | 11 | The Forever Purge | $748,030 | -54.9% | 779 | -387 | $960 | $43,987,280 | 6 | Universal Pictures | false | false |
| 13 | 12 | A Quiet Place Part II | $506,489 | -45.9% | 520 | -259 | $974 | $159,613,039 | 11 | Paramount Pictures | false | false |
| 14 | 26 | Nine Days | $382,509 | +1,394.4% | 443 | +439 | $863 | $408,106 | 2 | Sony Pictures Classics | false | false |
| 15 | 13 | Roadrunner: A Film About Anthony Bourdain | $266,880 | -53.3% | 268 | -269 | $995 | $5,067,960 | 4 | Focus Features | false | false |
| 16 | - | The Conjuring: The Devil Made Me Do It | $253,768 | - | 100 | - | $2,537 | $65,466,992 | 10 | Warner Bros. | false | false |
| 17 | 14 | Cruella | $203,441 | -61.4% | 148 | -87 | $1,374 | $85,776,944 | 11 | Walt Disney Studios Motion Pictures | false | false |
| 18 | 15 | Pig | $175,588 | -55.3% | 170 | -166 | $1,032 | $2,979,267 | 4 | Neon | false | false |
| 19 | 17 | Hitman's Wife's Bodyguard | $133,012 | -46.6% | 179 | -81 | $743 | $37,966,944 | 9 | Lionsgate | false | false |
| 20 | 33 | Ailey | $81,079 | +709.1% | 88 | +86 | $921 | $112,645 | 3 | Neon | false | false |
| 21 | - | In the Heights | $71,835 | - | 191 | - | $376 | $29,879,041 | 9 | Warner Bros. | false | false |
| 22 | 20 | Peter Rabbit 2: The Runaway | $61,191 | -27.6% | 119 | -61 | $514 | $40,336,536 | 9 | Sony Pictures Releasing | false | false |
| 23 | 21 | Once I Was Engaged | $53,045 | +29.1% | 30 | - | $1,768 | $215,834 | 4 | Excel Entertainment | false | false |
| 24 | 48 | Dream Horse | $47,684 | +3,471.8% | 56 | +39 | $851 | $2,913,328 | 12 | Bleecker Street Media | false | false |
| 25 | 19 | Zola | $42,919 | -50.3% | 35 | -79 | $1,226 | $4,802,009 | 7 | A24 | false | false |
| 26 | - | Swan Song | $42,124 | - | 37 | - | $1,138 | $42,124 | 1 | Magnolia Pictures | true | false |
| 27 | 18 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $37,035 | -58.3% | 42 | -43 | $881 | $2,273,651 | 7 | Searchlight Pictures | false | false |
| 28 | 24 | 12 Mighty Orphans | $30,430 | -10.2% | 42 | -8 | $724 | $3,523,578 | 9 | Sony Pictures Releasing | false | false |
| 29 | 16 | Joe Bell | $29,564 | -89.2% | 113 | -940 | $261 | $1,399,318 | 3 | Roadside Attractions | false | false |
| 30 | 25 | Queen Bees | $24,435 | -13.1% | 47 | - | $519 | $1,919,451 | 9 | Gravitas Ventures | false | false |
| 31 | - | John and the Hole | $22,162 | - | 42 | - | $527 | $22,162 | 1 | IFC Films | true | false |
| 32 | 22 | Raya and the Last Dragon | $18,188 | -52.6% | 24 | -6 | $757 | $54,721,194 | 23 | Walt Disney Studios Motion Pictures | false | false |
| 33 | - | Bring Your Own Brigade | $13,375 | - | 27 | - | $495 | $13,375 | 1 | Paramount Pictures | true | false |
| 34 | 29 | Witnesses | $12,546 | -9.8% | 10 | -2 | $1,254 | $836,541 | 10 | Purdie Distribution | false | false |
| 35 | 38 | CatVideoFest 2021 | $12,484 | +188.6% | 12 | +4 | $1,040 | $67,277 | 3 | Oscilloscope | false | false |
| 36 | 27 | Without Getting Killed or Caught | $11,391 | -33.4% | 6 | -1 | $1,898 | $37,965 | 3 | mTuckman Media | false | false |
| 37 | - | Even in Dreams | $8,264 | - | 5 | - | $1,652 | $8,264 | 1 | Purdie Distribution | true | false |
| 38 | 40 | Sabaya | $6,792 | +85.7% | 14 | +13 | $485 | $10,450 | 2 | MTV Documentary Films | false | false |
| 39 | 39 | Never Gonna Snow Again | $4,812 | +12.7% | 8 | +3 | $601 | $7,868 | 2 | Kino Lorber | false | false |
| 40 | 35 | The Swimming Pool 2021 Re-release | $4,744 | -9% | 3 | - | $1,581 | $147,824 | 13 | Rialto Distribution | false | false |
| 41 | 37 | The Loneliest Whale: The Search for 52 | $3,458 | -26.9% | 20 | - | $172 | $107,798 | 5 | Bleecker Street Media | false | false |
| 42 | 28 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $3,398 | -79.9% | 11 | -10 | $308 | $49,505,008 | 16 | FUNimation Entertainment | false | false |
| 43 | 32 | Lorelei | $2,515 | -75.2% | 5 | -6 | $503 | $12,642 | 2 | Freestyle Releasing | false | false |
| 44 | 46 | Summertime | $2,414 | -18.4% | 14 | +4 | $172 | $70,147 | 5 | Good Deed Entertainment | false | false |
| 45 | 47 | Lydia Lunch: The War Is Never Over | $2,316 | +33.1% | 4 | +2 | $579 | $12,222 | 7 | Kino Lorber | false | false |
| 46 | 31 | The Truffle Hunters | $2,245 | -80.6% | 4 | -10 | $561 | $521,202 | 23 | Sony Pictures Classics | false | false |
| 47 | 41 | Mandibles | $1,968 | -44.7% | 6 | -8 | $328 | $19,304 | 3 | Magnet Releasing | false | false |
| 48 | 43 | Mama Weed | $1,276 | -63.3% | 3 | -5 | $425 | $26,331 | 4 | Music Box Films | false | false |
| 49 | 36 | I Carry You with Me | $1,255 | -75.9% | 4 | -14 | $313 | $166,403 | 7 | Sony Pictures Classics | false | false |
| 50 | - | The Incredible 25th Year of Mitzi Bearclaw | $1,160 | - | 1 | - | $1,160 | $9,371 | 26 | Indican Pictures | false | false |
| 51 | 49 | Can You Bring It: Bill T. Jones and D-Man in the Waters | $1,017 | -3.8% | 3 | -1 | $339 | $9,563 | 4 | Kino Lorber | false | false |
| 52 | 34 | Enemies of the State | $784 | -89.2% | 5 | -8 | $156 | $8,074 | 2 | IFC Films | false | false |
| 53 | 44 | Werewolves Within | $628 | -81.4% | 11 | - | $57 | $575,783 | 7 | IFC Films | false | false |
| 54 | 42 | No Ordinary Man | $515 | -85.4% | 3 | -6 | $171 | $13,174 | 4 | Oscilloscope | false | false |
| 55 | 45 | Casanova, Last Love | $288 | -90.8% | 2 | -4 | $144 | $9,926 | 5 | Cohen Media Group | false | false |
| 56 | 53 | The Red Circle 2021 Re-release | $190 | -53.9% | 1 | - | $190 | $58,393 | 7 | Rialto Pictures | false | false |
| 57 | 56 | Shiva Baby | $69 | +115.6% | 1 | - | $69 | $156,908 | 19 | Utopia | false | false |
