| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Old | $23,853,255 | - | 3,355 | - | $7,109 | $23,853,255 | 1 | Universal Pictures | true | false |
| 2 | - | Snake Eyes | $18,282,544 | - | 3,521 | - | $5,192 | $18,282,544 | 1 | Paramount Pictures | true | false |
| 3 | 2 | Black Widow | $17,434,179 | -53.4% | 4,250 | -25 | $4,102 | $160,640,862 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 4 | 1 | Space Jam: A New Legacy | $14,666,838 | -64.9% | 4,002 | +37 | $3,664 | $56,474,443 | 2 | Warner Bros. | false | false |
| 5 | 4 | F9: The Fast Saga | $7,197,790 | -37.3% | 2,850 | -518 | $2,525 | $165,894,615 | 5 | Universal Pictures | false | false |
| 6 | 3 | Escape Room: Tournament of Champions | $5,703,462 | -54.9% | 2,815 | - | $2,026 | $18,351,732 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | The Boss Baby: Family Business | $4,734,605 | -37% | 2,773 | -676 | $1,707 | $52,167,240 | 4 | Universal Pictures | false | false |
| 8 | 6 | The Forever Purge | $3,572,605 | -42.9% | 2,113 | -622 | $1,690 | $41,579,315 | 4 | Universal Pictures | false | false |
| 9 | 7 | A Quiet Place Part II | $1,896,907 | -46.5% | 1,397 | -598 | $1,357 | $158,170,530 | 9 | Paramount Pictures | false | false |
| 10 | 8 | Roadrunner: A Film About Anthony Bourdain | $1,358,675 | -52.7% | 954 | +27 | $1,424 | $4,230,155 | 2 | Focus Features | false | false |
| 11 | - | Joe Bell | $1,095,444 | - | 1,094 | - | $1,001 | $1,095,444 | 1 | Roadside Attractions | true | false |
| 12 | 10 | Pig | $945,280 | -35.5% | 588 | +36 | $1,607 | $2,411,212 | 2 | Neon | false | false |
| 13 | 9 | Cruella | $811,542 | -57.7% | 495 | -680 | $1,639 | $85,046,386 | 9 | Walt Disney Studios Motion Pictures | false | false |
| 14 | 11 | Hitman's Wife's Bodyguard | $485,897 | -59.5% | 476 | -558 | $1,020 | $37,585,006 | 7 | Lionsgate | false | false |
| 15 | 12 | Peter Rabbit 2: The Runaway | $454,949 | -56.4% | 578 | -539 | $787 | $40,190,829 | 7 | Sony Pictures Releasing | false | false |
| 16 | 13 | In the Heights | $315,704 | -47.6% | 305 | -1,100 | $1,035 | $29,636,918 | 7 | Warner Bros. | false | false |
| 17 | 14 | The Conjuring: The Devil Made Me Do It | $276,272 | -53.1% | 1,716 | - | $160 | $65,090,253 | 8 | Warner Bros. | false | false |
| 18 | - | Weathering with You | $257,893 | - | 644 | - | $400 | $8,056,636 | 81 | GKIDS | false | false |
| 19 | 15 | Zola | $194,445 | -58.9% | 229 | -304 | $849 | $4,672,782 | 5 | A24 | false | false |
| 20 | - | Kaamelott: First Installment | $188,000 | - | 26 | - | $7,230 | $188,000 | 1 | Paramount Pictures | true | false |
| 21 | 16 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $167,180 | -42.2% | 150 | -125 | $1,114 | $2,147,781 | 5 | Searchlight Pictures | false | false |
| 22 | 17 | 12 Mighty Orphans | $85,368 | -37.6% | 74 | -66 | $1,153 | $3,460,268 | 7 | Sony Pictures Releasing | false | false |
| 23 | 21 | Once I Was Engaged | $78,474 | +81.6% | 32 | +4 | $2,452 | $121,694 | 2 | Excel Entertainment | false | false |
| 24 | 18 | Spirit Untamed | $68,705 | -31.7% | 895 | -15 | $76 | $17,598,585 | 8 | Universal Pictures | false | false |
| 25 | - | CatVideoFest 2021 | $50,467 | - | 40 | - | $1,261 | $50,467 | 1 | Oscilloscope | true | false |
| 26 | 19 | Queen Bees | $46,335 | -51.4% | 83 | -40 | $558 | $1,866,883 | 7 | Gravitas Ventures | false | false |
| 27 | 26 | Raya and the Last Dragon | $35,481 | +50.7% | 35 | -6 | $1,013 | $54,664,601 | 21 | Walt Disney Studios Motion Pictures | false | false |
| 28 | 24 | Witnesses | $22,050 | -26.8% | 17 | -6 | $1,297 | $810,084 | 8 | Purdie Distribution | false | false |
| 29 | 20 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $21,595 | -62.4% | 24 | -15 | $899 | $49,484,676 | 14 | FUNimation Entertainment | false | false |
| 30 | - | Ailey | $21,545 | - | 2 | - | $10,772 | $21,545 | 1 | Neon | true | false |
| 31 | - | Settlers | $15,825 | - | 30 | - | $527 | $15,825 | 1 | IFC Films | true | false |
| 32 | - | Mandibles | $13,779 | - | 24 | - | $574 | $13,779 | 1 | Magnet Releasing | true | false |
| 33 | - | Secret Agent Dingledorf and His Trusty Dog Splat | $13,300 | - | 30 | - | $443 | $13,300 | 4 | Integrity Releasing | false | false |
| 34 | 35 | How It Ends | $10,036 | +65.4% | 10 | -1 | $1,003 | $16,104 | 2 | United Artists | false | false |
| 35 | 22 | I Carry You with Me | $9,689 | -76.6% | 44 | -67 | $220 | $159,936 | 5 | Sony Pictures Classics | false | false |
| 36 | - | Without Getting Killed or Caught | $9,463 | - | 1 | - | $9,463 | $9,463 | 1 | mTuckman Media | true | false |
| 37 | 30 | The Truffle Hunters | $8,676 | -33.7% | 12 | -3 | $723 | $507,393 | 21 | Sony Pictures Classics | false | false |
| 38 | 31 | Wrath of Man | $8,188 | -32.8% | 37 | -8 | $221 | $27,466,489 | 12 | United Artists Releasing | false | false |
| 39 | 27 | Werewolves Within | $8,025 | -62.5% | 17 | -29 | $472 | $571,784 | 5 | IFC Films | false | false |
| 40 | 33 | The Swimming Pool 2021 Re-release | $7,864 | -14.6% | 3 | -1 | $2,621 | $137,864 | 11 | Rialto Distribution | false | false |
| 41 | 25 | The Loneliest Whale: The Search for 52 | $7,239 | -74.2% | 20 | -51 | $361 | $99,612 | 3 | Bleecker Street Media | false | false |
| 42 | 32 | The Red Circle 2021 Re-release | $7,018 | -31.1% | 4 | -1 | $1,754 | $57,601 | 5 | Rialto Pictures | false | false |
| 43 | 23 | Summertime | $6,760 | -81.5% | 29 | -35 | $233 | $64,773 | 3 | Good Deed Entertainment | false | false |
| 44 | 29 | Dream Horse | $6,010 | -57.9% | 17 | -13 | $353 | $2,864,309 | 10 | Bleecker Street Media | false | false |
| 45 | - | Here After | $5,612 | - | 1 | - | $5,612 | $5,612 | 1 | Vertical Entertainment | true | false |
| 46 | 28 | Mama Weed | $4,666 | -72.4% | 10 | -10 | $466 | $21,581 | 2 | Music Box Films | false | false |
| 47 | - | No Ordinary Man | $4,013 | - | 9 | - | $445 | $9,140 | 2 | Oscilloscope | false | false |
| 48 | 34 | Rita Moreno: Just a Girl Who Decided to Go for It | $3,943 | -45.5% | 12 | -4 | $328 | $264,626 | 6 | Roadside Attractions | false | false |
| 49 | - | Can You Bring It: Bill T. Jones and D-Man in the Waters | $3,712 | - | 7 | - | $530 | $7,489 | 2 | Kino Lorber | false | false |
| 50 | 46 | The Ladykillers 2021 Re-release | $2,564 | +729.8% | 3 | +2 | $854 | $21,375 | 8 | Rialto Pictures | false | false |
| 51 | - | Victim of Love | $2,393 | - | 1 | - | $2,393 | $2,393 | 1 | Indican Pictures | true | false |
| 52 | 38 | Casanova, Last Love | $2,132 | -37.6% | 4 | -2 | $533 | $6,514 | 3 | Cohen Media Group | false | false |
| 53 | 36 | Summer of 85 | $1,900 | -62.7% | 5 | -5 | $380 | $70,487 | 6 | Music Box Films | false | false |
| 54 | - | Together Together | $1,602 | - | 2 | - | $801 | $1,437,938 | 14 | Bleecker Street Media | false | false |
| 55 | 37 | Rock Paper Scissors | $1,471 | -63.5% | 1 | -1 | $1,471 | $5,497 | 2 | Indican Pictures | false | false |
| 56 | - | Truman & Tennessee: An Intimate Conversation | $1,093 | - | 4 | - | $273 | $54,817 | 6 | Kino Lorber | false | false |
| 57 | 40 | The Dry | $1,019 | -64.2% | 3 | -2 | $339 | $363,570 | 10 | IFC Films | false | false |
| 58 | 42 | Undine | $481 | -72.9% | 2 | -2 | $240 | $78,689 | 8 | IFC Films | false | false |
| 59 | 41 | Shiva Baby | $150 | -94.6% | 1 | -3 | $150 | $156,702 | 17 | Utopia | false | false |
| 60 | - | Mission Stories | $146 | - | 1 | - | $146 | $86,992 | 12 | Excel Entertainment | false | false |
| 61 | 47 | The Perfect Candidate | $56 | +19.1% | 1 | - | $56 | $28,720 | 11 | Music Box Films | false | false |
