| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Space Jam: A New Legacy | $41,807,605 | - | 3,965 | - | $10,544 | $41,807,605 | 1 | Warner Bros. | true | false |
| 2 | 1 | Black Widow | $37,445,012 | -64.6% | 4,275 | +115 | $8,759 | $143,206,683 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 3 | - | Escape Room: Tournament of Champions | $12,648,270 | - | 2,815 | - | $4,493 | $12,648,270 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | F9: The Fast Saga | $11,477,870 | -31.6% | 3,368 | -281 | $3,407 | $158,696,825 | 4 | Universal Pictures | false | false |
| 5 | 3 | The Boss Baby: Family Business | $7,510,960 | -45.9% | 3,449 | -239 | $2,177 | $47,432,635 | 3 | Universal Pictures | false | false |
| 6 | 4 | The Forever Purge | $6,256,000 | -43.2% | 2,735 | -323 | $2,287 | $38,006,710 | 3 | Universal Pictures | false | false |
| 7 | 5 | A Quiet Place Part II | $3,545,753 | -29.6% | 1,995 | -364 | $1,777 | $156,273,623 | 8 | Paramount Pictures | false | false |
| 8 | - | Roadrunner: A Film About Anthony Bourdain | $2,871,480 | - | 927 | - | $3,097 | $2,871,480 | 1 | Focus Features | true | false |
| 9 | 6 | Cruella | $1,917,327 | -48.9% | 1,175 | -700 | $1,631 | $84,234,844 | 8 | Walt Disney Studios Motion Pictures | false | false |
| 10 | - | Pig | $1,465,932 | - | 552 | - | $2,655 | $1,465,932 | 1 | Neon | true | false |
| 11 | 7 | Hitman's Wife's Bodyguard | $1,200,978 | -51.7% | 1,034 | -870 | $1,161 | $37,099,109 | 6 | Lionsgate | false | false |
| 12 | 8 | Peter Rabbit 2: The Runaway | $1,043,561 | -53.5% | 1,117 | -841 | $934 | $39,735,880 | 6 | Sony Pictures Releasing | false | false |
| 13 | 11 | In the Heights | $602,696 | -41.5% | 1,405 | - | $428 | $29,321,214 | 6 | Warner Bros. | false | false |
| 14 | 10 | The Conjuring: The Devil Made Me Do It | $589,441 | -43.7% | 1,716 | - | $343 | $64,813,981 | 7 | Warner Bros. | false | false |
| 15 | 9 | Zola | $472,699 | -56.8% | 533 | -868 | $886 | $4,478,337 | 4 | A24 | false | false |
| 16 | 12 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $289,235 | -54.7% | 275 | -477 | $1,051 | $1,980,601 | 4 | Searchlight Pictures | false | false |
| 17 | 14 | 12 Mighty Orphans | $136,731 | -35.9% | 140 | -45 | $976 | $3,374,900 | 6 | Sony Pictures Releasing | false | false |
| 18 | 13 | Spirit Untamed | $100,600 | -55.2% | 910 | -58 | $110 | $17,529,880 | 7 | Universal Pictures | false | false |
| 19 | 15 | Queen Bees | $95,392 | -22.9% | 123 | -40 | $775 | $1,820,548 | 6 | Gravitas Ventures | false | false |
| 20 | 17 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $57,401 | -10.8% | 39 | -3 | $1,471 | $49,463,081 | 13 | FUNimation Entertainment | false | false |
| 21 | - | Once I Was Engaged | $43,220 | - | 28 | - | $1,543 | $43,220 | 1 | Excel Entertainment | true | false |
| 22 | 19 | I Carry You with Me | $41,447 | -11.8% | 111 | +54 | $373 | $150,247 | 4 | Sony Pictures Classics | false | false |
| 23 | - | Summertime | $36,523 | - | 64 | - | $570 | $58,013 | 2 | Good Deed Entertainment | false | false |
| 24 | 22 | Witnesses | $30,135 | -30.6% | 23 | -5 | $1,310 | $788,034 | 7 | Purdie Distribution | false | false |
| 25 | 18 | The Loneliest Whale: The Search for 52 | $28,075 | -56.3% | 71 | - | $395 | $92,373 | 2 | Bleecker Street Media | false | false |
| 26 | 20 | Raya and the Last Dragon | $23,540 | -48.5% | 41 | -14 | $574 | $54,629,120 | 20 | Walt Disney Studios Motion Pictures | false | false |
| 27 | 21 | Werewolves Within | $21,410 | -50.9% | 46 | -17 | $465 | $563,759 | 4 | IFC Films | false | false |
| 28 | - | Mama Weed | $16,915 | - | 20 | - | $845 | $16,915 | 1 | Music Box Films | true | false |
| 29 | 23 | Dream Horse | $14,283 | -45.6% | 30 | -14 | $476 | $2,858,299 | 9 | Bleecker Street Media | false | false |
| 30 | 25 | The Truffle Hunters | $13,078 | -29.4% | 15 | -3 | $871 | $498,717 | 20 | Sony Pictures Classics | false | false |
| 31 | 24 | Wrath of Man | $12,180 | -38% | 45 | -5 | $270 | $27,458,301 | 11 | United Artists Releasing | false | false |
| 32 | 26 | The Red Circle 2021 Re-release | $10,182 | -13.5% | 5 | +1 | $2,036 | $50,583 | 4 | Rialto Pictures | false | false |
| 33 | 31 | The Swimming Pool 2021 Re-release | $9,212 | +33% | 4 | -4 | $2,303 | $130,000 | 10 | Rialto Distribution | false | false |
| 34 | 27 | Rita Moreno: Just a Girl Who Decided to Go for It | $7,241 | -24.5% | 16 | -7 | $452 | $260,683 | 5 | Roadside Attractions | false | false |
| 35 | - | How It Ends | $6,068 | - | 11 | - | $551 | $6,068 | 1 | United Artists | true | false |
| 36 | 28 | Summer of 85 | $5,095 | -40.1% | 10 | -3 | $509 | $68,587 | 5 | Music Box Films | false | false |
| 37 | - | Rock Paper Scissors | $4,026 | - | 2 | - | $2,013 | $4,026 | 1 | Indican Pictures | true | false |
| 38 | 38 | Casanova, Last Love | $3,418 | +254.6% | 6 | +2 | $569 | $4,382 | 2 | Cohen Media Group | false | false |
| 39 | 40 | About Endlessness | $2,893 | +1,332.2% | 5 | +4 | $578 | $51,386 | 12 | Magnolia Pictures | false | false |
| 40 | - | The Dry | $2,844 | - | 5 | - | $568 | $362,551 | 9 | IFC Films | false | false |
| 41 | 34 | Shiva Baby | $2,802 | +3.8% | 4 | -1 | $700 | $156,552 | 16 | Utopia | false | false |
| 42 | - | Undine | $1,775 | - | 4 | - | $443 | $78,208 | 7 | IFC Films | false | false |
| 43 | 39 | A Soldier's Story 2: Return from the Dead | $499 | +14.4% | 1 | -1 | $499 | $21,543 | 4 | Indican Pictures | false | false |
| 44 | 35 | Censor | $446 | -82.9% | 2 | -4 | $223 | $90,050 | 6 | Magnolia Pictures | false | false |
| 45 | - | Sweat | $393 | - | 3 | - | $131 | $11,546 | 5 | MUBI | false | false |
| 46 | 36 | The Ladykillers 2021 Re-release | $309 | -80.5% | 1 | -2 | $309 | $18,811 | 7 | Rialto Pictures | false | false |
| 47 | 41 | The Perfect Candidate | $47 | -58.8% | 1 | - | $47 | $28,664 | 10 | Music Box Films | false | false |
