| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Black Widow | $105,761,671 | - | 4,160 | - | $25,423 | $105,761,671 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 2 | 1 | F9: The Fast Saga | $16,773,230 | -55.1% | 3,649 | -554 | $4,596 | $147,218,955 | 3 | Universal Pictures | false | false |
| 3 | 2 | The Boss Baby: Family Business | $13,875,165 | -46.7% | 3,688 | +44 | $3,762 | $39,921,675 | 2 | Universal Pictures | false | false |
| 4 | 3 | The Forever Purge | $11,015,795 | -46.9% | 3,058 | +7 | $3,602 | $31,750,710 | 2 | Universal Pictures | false | false |
| 5 | 4 | A Quiet Place Part II | $5,033,575 | -32.7% | 2,359 | -467 | $2,133 | $152,727,870 | 7 | Paramount Pictures | false | false |
| 6 | 6 | Cruella | $3,750,852 | -17.2% | 1,875 | -505 | $2,000 | $82,317,517 | 7 | Walt Disney Studios Motion Pictures | false | false |
| 7 | 5 | Hitman's Wife's Bodyguard | $2,488,284 | -50.5% | 1,904 | -1,457 | $1,306 | $35,898,131 | 5 | Lionsgate | false | false |
| 8 | 7 | Peter Rabbit 2: The Runaway | $2,242,315 | -47.7% | 1,958 | -996 | $1,145 | $38,692,319 | 5 | Sony Pictures Releasing | false | false |
| 9 | 9 | Zola | $1,094,075 | -48.3% | 1,401 | -67 | $780 | $4,005,638 | 3 | A24 | false | false |
| 10 | 8 | The Conjuring: The Devil Made Me Do It | $1,046,787 | -53.3% | 1,716 | - | $610 | $64,224,540 | 6 | Warner Bros. | false | false |
| 11 | 10 | In the Heights | $1,030,966 | -50.3% | 1,405 | - | $733 | $28,718,518 | 5 | Warner Bros. | false | false |
| 12 | 11 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $638,842 | -39.3% | 752 | - | $849 | $1,691,366 | 3 | Searchlight Pictures | false | false |
| 13 | 12 | Spirit Untamed | $224,515 | -65.4% | 968 | -328 | $231 | $17,429,280 | 6 | Universal Pictures | false | false |
| 14 | 13 | 12 Mighty Orphans | $213,159 | -51.5% | 185 | -153 | $1,152 | $3,238,169 | 5 | Sony Pictures Releasing | false | false |
| 15 | 15 | Queen Bees | $123,735 | -24.6% | 163 | -7 | $759 | $1,725,156 | 5 | Gravitas Ventures | false | false |
| 16 | - | The House Next Door: Meet the Blacks 2 | $64,913 | - | 44 | - | $1,475 | $2,893,660 | 5 | Hidden Empire Film Group (HEFG) | false | false |
| 17 | 17 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $64,338 | -47.7% | 42 | -39 | $1,531 | $49,405,680 | 12 | FUNimation Entertainment | false | false |
| 18 | - | The Loneliest Whale: The Search for 52 | $64,298 | - | 71 | - | $905 | $64,298 | 1 | Bleecker Street Media | true | false |
| 19 | 23 | I Carry You with Me | $47,011 | +22.9% | 57 | +33 | $824 | $108,800 | 3 | Sony Pictures Classics | false | false |
| 20 | 20 | Raya and the Last Dragon | $45,681 | -27.7% | 55 | -20 | $830 | $54,605,580 | 19 | Walt Disney Studios Motion Pictures | false | false |
| 21 | 16 | Werewolves Within | $43,615 | -69% | 63 | -146 | $692 | $542,349 | 3 | IFC Films | false | false |
| 22 | 19 | Witnesses | $43,431 | -42.8% | 28 | -8 | $1,551 | $757,899 | 6 | Purdie Distribution | false | false |
| 23 | 24 | Dream Horse | $26,242 | +2.8% | 44 | -29 | $596 | $2,844,016 | 8 | Bleecker Street Media | false | false |
| 24 | 18 | Wrath of Man | $19,650 | -74.8% | 50 | -32 | $393 | $27,446,121 | 10 | United Artists Releasing | false | false |
| 25 | 27 | The Truffle Hunters | $18,529 | -17.6% | 18 | -7 | $1,029 | $485,639 | 19 | Sony Pictures Classics | false | false |
| 26 | 33 | The Red Circle 2021 Re-release | $11,771 | +3.3% | 4 | +3 | $2,942 | $40,401 | 3 | Rialto Pictures | false | false |
| 27 | 25 | Rita Moreno: Just a Girl Who Decided to Go for It | $9,591 | -62.4% | 23 | -33 | $417 | $253,442 | 4 | Roadside Attractions | false | false |
| 28 | 29 | Summer of 85 | $8,503 | -39.4% | 13 | -6 | $654 | $63,492 | 4 | Music Box Films | false | false |
| 29 | 26 | The God Committee | $8,471 | -65.4% | 25 | -3 | $338 | $32,934 | 2 | Vertical Entertainment | false | false |
| 30 | 31 | Truman & Tennessee: An Intimate Conversation | $7,004 | -46.4% | 13 | -8 | $538 | $53,032 | 4 | Kino Lorber | false | false |
| 31 | 30 | The Swimming Pool 2021 Re-release | $6,928 | -48% | 8 | -1 | $866 | $120,788 | 9 | Rialto Distribution | false | false |
| 32 | - | Scales | $4,617 | - | 2 | - | $2,308 | $4,617 | 1 | Variance Films | true | false |
| 33 | 32 | First Date | $3,026 | -76.6% | 13 | -8 | $232 | $15,974 | 2 | Magnolia Pictures | false | false |
| 34 | 35 | Shiva Baby | $2,700 | -47.3% | 5 | -2 | $540 | $153,750 | 15 | Utopia | false | false |
| 35 | 40 | Censor | $2,610 | -11.3% | 6 | +2 | $435 | $89,604 | 5 | Magnolia Pictures | false | false |
| 36 | 37 | The Ladykillers 2021 Re-release | $1,585 | -61.8% | 3 | - | $528 | $18,502 | 6 | Rialto Pictures | false | false |
| 37 | 39 | Lydia Lunch: The War Is Never Over | $1,329 | -61.9% | 4 | +3 | $332 | $8,166 | 3 | Kino Lorber | false | false |
| 38 | - | Casanova, Last Love | $964 | - | 4 | - | $241 | $964 | 1 | Cohen Media Group | true | false |
| 39 | 36 | A Soldier's Story 2: Return from the Dead | $436 | -89.7% | 2 | -2 | $218 | $21,044 | 3 | Indican Pictures | false | false |
| 40 | 42 | About Endlessness | $202 | -90.9% | 1 | - | $202 | $48,493 | 11 | Magnolia Pictures | false | false |
| 41 | - | The Perfect Candidate | $114 | - | 1 | - | $114 | $28,617 | 9 | Music Box Films | false | false |
