| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ghost Rider | $2,050,782 | - | 350 | - | $5,859 | $2,050,782 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | KM 31: Kilometre 31 | $1,019,814 | -30.6% | 275 | - | $3,708 | $6,284,133 | 3 | Videocine | false | false |
| 3 | 3 | The Pursuit of Happyness | $762,737 | -27.3% | 237 | -66 | $3,218 | $4,737,593 | 3 | Sony Pictures Releasing | false | false |
| 4 | 2 | Blood Diamond | $648,005 | -39.6% | 350 | - | $1,851 | $2,373,425 | 2 | Warner Bros. | false | false |
| 5 | 4 | Apocalypto | $339,930 | -48.4% | 321 | -50 | $1,058 | $7,413,769 | 4 | 20th Century Fox International | false | false |
| 6 | 5 | Perfume: The Story of a Murderer | $221,350 | -22.2% | 166 | -33 | $1,333 | $3,931,324 | 5 | Gussi Films | false | false |
| 7 | - | Never on a Sunday | $175,270 | - | 200 | - | $876 | $175,270 | 1 | Gussi Films | true | false |
| 8 | 7 | Pan's Labyrinth | $167,949 | -8.1% | 120 | - | $1,399 | $5,825,121 | 18 | Warner Bros. | false | false |
| 9 | 6 | Night at the Museum | $156,946 | -44.6% | 207 | -91 | $758 | $19,352,884 | 9 | 20th Century Fox International | false | false |
| 10 | - | How Much Do You Love Me? | $111,723 | - | 103 | - | $1,084 | $111,723 | 1 | Azteca Films | true | false |
| 11 | 9 | The Holiday | $97,384 | -40.2% | 106 | -41 | $918 | $3,248,882 | 6 | Universal Pictures International (UPI) | false | false |
| 12 | 11 | Fuera del cielo | $69,151 | -31.3% | 103 | -55 | $671 | $2,789,752 | 6 | Videocine | false | false |
| 13 | 8 | Employee of the Month | $68,403 | -59.2% | 124 | -24 | $551 | $353,479 | 2 | Videocine | false | false |
| 14 | - | Flags of Our Fathers | $59,889 | - | 73 | - | $820 | $313,654 | 4 | Warner Bros. | false | false |
| 15 | - | The Texas Chainsaw Massacre: The Beginning | $57,995 | - | 74 | - | $783 | $338,467 | 4 | Gussi Films | false | false |
| 16 | - | Letters from Iwo Jima | $57,710 | - | 50 | - | $1,154 | $57,710 | 1 | Warner Bros. | true | false |
| 17 | 10 | Rocky Balboa | $55,623 | -62.4% | 99 | -71 | $561 | $4,784,464 | 6 | 20th Century Fox International | false | false |
| 18 | 18 | Dreamgirls | $49,056 | +6.1% | 86 | +11 | $570 | $614,219 | 4 | Paramount Pictures International | false | false |
| 19 | - | Borat | $44,065 | - | 49 | - | $899 | $808,486 | 7 | 20th Century Fox International | false | false |
| 20 | 20 | Saint Ange 2006 Re-release | $38,374 | -3.8% | 51 | +8 | $752 | $800,276 | 8 | Gussi Films | false | false |
