| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $167,773 | -13.7% | 54 | - | $3,106 | $1,497,859 | 5 | 20th Century Fox International | false | false |
| 2 | 3 | Babel | $83,286 | -17.3% | 32 | -1 | $2,602 | $653,588 | 5 | United International Pictures | false | false |
| 3 | 4 | Blood Diamond | $75,236 | -12.1% | 23 | -4 | $3,271 | $267,845 | 3 | Warner Bros. | false | false |
| 4 | 2 | Rocky Balboa | $72,852 | -46.3% | 39 | -4 | $1,868 | $209,809 | 2 | 20th Century Fox International | false | false |
| 5 | - | Letters from Iwo Jima | $50,834 | - | 10 | - | $5,083 | $50,834 | 1 | Warner Bros. | true | false |
| 6 | 5 | The Pursuit of Happyness | $44,528 | -21.3% | 11 | - | $4,048 | $101,631 | 2 | Sony Pictures Releasing | false | false |
| 7 | 6 | The Illusionist | $39,448 | -3.6% | 14 | -1 | $2,817 | $391,571 | 6 | Transeuropa | false | false |
| 8 | 8 | Deja Vu | $27,199 | +8.6% | 13 | -1 | $2,092 | $273,942 | 6 | Buena Vista International | false | false |
| 9 | 14 | Charlotte's Web | $26,244 | +106.1% | 18 | +7 | $1,458 | $165,892 | 6 | United International Pictures | false | false |
| 10 | 9 | Flushed Away | $25,511 | +7.3% | 16 | -5 | $1,594 | $1,032,101 | 10 | United International Pictures | false | false |
| 11 | - | The Last King of Scotland | $23,064 | - | 5 | - | $4,612 | $23,064 | 1 | 20th Century Fox International | true | false |
| 12 | 7 | Eragon | $16,441 | -34.9% | 14 | -3 | $1,174 | $828,312 | 7 | 20th Century Fox International | false | false |
| 13 | 10 | Children of Men | $16,105 | -28.1% | 14 | -1 | $1,150 | $139,695 | 4 | United International Pictures | false | false |
| 14 | 12 | Flags of Our Fathers | $14,385 | -9% | 10 | - | $1,438 | $91,368 | 4 | Warner Bros. | false | false |
| 15 | - | Dreamgirls | $13,105 | - | 7 | - | $1,872 | $13,105 | 1 | United International Pictures | true | false |
| 16 | 13 | Cry Wolf | $11,562 | -24.3% | 9 | -2 | $1,284 | $48,327 | 3 | Bazuca Films | false | false |
| 17 | 18 | Little Miss Sunshine | $10,428 | +170.6% | 4 | - | $2,607 | $126,315 | 9 | 20th Century Fox International | false | false |
| 18 | 11 | The Departed | $9,255 | -49.1% | 5 | -3 | $1,851 | $781,614 | 14 | Warner Bros. | false | false |
| 19 | 15 | Marie Antoinette | $8,873 | +94.8% | 4 | +2 | $2,218 | $109,147 | 6 | Sony Pictures Releasing | false | false |
| 20 | 17 | Happy Feet | $4,309 | +6.8% | 6 | -1 | $718 | $808,964 | 12 | Warner Bros. | false | false |
