| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Saw III | $661,086 | - | 65 | - | $10,170 | $788,342 | 2 | Luna Filmverleih | false | false |
| 2 | - | The Wild Guys 4 | $553,798 | - | 78 | - | $7,099 | $574,897 | 2 | Buena Vista International | false | false |
| 3 | 1 | Blood Diamond | $339,318 | -19.1% | 65 | - | $5,220 | $786,039 | 3 | Warner Bros. | false | false |
| 4 | - | Dreamgirls | $256,535 | - | 46 | - | $5,576 | $258,370 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 2 | The Pursuit of Happyness | $181,299 | -21.4% | 52 | - | $3,486 | $746,292 | 4 | Sony Pictures Releasing | false | false |
| 6 | 3 | John Tucker Must Die | $167,967 | -20.5% | 50 | +3 | $3,359 | $735,431 | 4 | - | false | false |
| 7 | 4 | Arthur and the Invisibles | $159,524 | +11.9% | 51 | - | $3,127 | $302,632 | 3 | Constantin Film | false | false |
| 8 | 5 | Babel | $120,431 | -4.8% | 22 | +2 | $5,474 | $1,155,779 | 8 | Constantin Film | false | false |
| 9 | 6 | The Queen | $98,822 | -19.1% | 25 | -1 | $3,952 | $574,831 | 5 | Filmladen | false | false |
| 10 | 16 | Night at the Museum | $93,391 | +152.8% | 79 | +34 | $1,182 | $2,731,613 | 7 | - | false | false |
| 11 | 8 | Charlotte's Web | $77,515 | -18.3% | 61 | - | $1,270 | $503,557 | 4 | Universal Pictures International (UPI) | false | false |
| 12 | 7 | My Führer | $74,497 | -37.9% | 34 | - | $2,191 | $332,697 | 4 | Filmladen | false | false |
| 13 | 13 | Grave Decisions | $49,113 | +8.1% | 29 | -1 | $1,693 | $735,759 | 13 | Luna Filmverleih | false | false |
| 14 | 11 | The Masked Gang: Iraq | $45,923 | -11.2% | 8 | - | $5,740 | $99,387 | 3 | Maxximum Film und Kunst GmbH | false | false |
| 15 | 10 | The Holiday | $45,072 | -32.1% | 81 | +20 | $556 | $2,836,508 | 9 | United International Pictures | false | false |
| 16 | 9 | One Way | $41,358 | -37.9% | 38 | - | $1,088 | $108,462 | 3 | Universal Pictures International (UPI) | false | false |
| 17 | 12 | The Departed | $38,395 | -16.2% | 44 | -13 | $872 | $2,069,081 | 10 | Warner Bros. | false | false |
| 18 | 15 | Deja Vu | $33,341 | -25.4% | 41 | -23 | $813 | $1,317,275 | 7 | Buena Vista International | false | false |
| 19 | 19 | Casino Royale | $25,758 | -14% | 31 | -4 | $830 | $5,838,597 | 12 | Sony Pictures Releasing | false | false |
| 20 | 17 | The Prestige | $25,708 | -19.2% | 24 | - | $1,071 | $513,252 | 6 | Warner Bros. | false | false |
