| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | John Tucker Must Die | $344,897 | - | 47 | - | $7,338 | $355,194 | 2 | - | false | false |
| 2 | - | The Pursuit of Happyness | $333,274 | - | 52 | - | $6,409 | $333,274 | 2 | Sony Pictures Releasing | false | false |
| 3 | 1 | Night at the Museum | $273,633 | -36% | 88 | - | $3,109 | $2,600,318 | 5 | - | false | false |
| 4 | 4 | The Queen | $163,286 | -13.7% | 26 | - | $6,280 | $353,170 | 3 | Filmladen | false | false |
| 5 | - | Charlotte's Web | $157,265 | - | 61 | - | $2,578 | $330,573 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | Babel | $154,148 | +0.8% | 20 | - | $7,707 | $906,519 | 6 | Constantin Film | false | false |
| 7 | 2 | The Holiday | $141,811 | -42.9% | 84 | -4 | $1,688 | $2,723,940 | 7 | United International Pictures | false | false |
| 8 | - | My Führer | $137,653 | - | 19 | - | $7,244 | $137,653 | 2 | Filmladen | false | false |
| 9 | 3 | Deja Vu | $112,480 | -50.9% | 75 | - | $1,499 | $1,238,597 | 5 | Buena Vista International | false | false |
| 10 | - | The Texas Chainsaw Massacre: The Beginning | $94,982 | - | 16 | - | $5,936 | $94,982 | 2 | Warner Bros. | false | false |
| 11 | 7 | The Departed | $91,459 | -30% | 65 | +1 | $1,407 | $1,984,045 | 8 | Warner Bros. | false | false |
| 12 | 6 | The Prestige | $75,419 | -46.2% | 24 | - | $3,142 | $455,461 | 4 | Warner Bros. | false | false |
| 13 | 10 | Grave Decisions | $71,124 | +11.9% | 30 | +1 | $2,370 | $657,203 | 11 | Luna Filmverleih | false | false |
| 14 | - | Flags of Our Fathers | $56,959 | - | 23 | - | $2,476 | $65,516 | 2 | Warner Bros. | false | false |
| 15 | 8 | Casino Royale | $53,314 | -51.1% | 46 | -8 | $1,159 | $5,780,912 | 10 | Sony Pictures Releasing | false | false |
| 16 | 12 | Flushed Away | $43,821 | -15.7% | 74 | +2 | $592 | $1,230,723 | 8 | United International Pictures | false | false |
| 17 | 9 | Eragon | $39,166 | -53.9% | 65 | -14 | $602 | $1,804,040 | 7 | 20th Century Fox International | false | false |
| 18 | 13 | Happy Feet | $38,243 | -23.4% | 74 | -5 | $516 | $1,640,063 | 9 | Warner Bros. | false | false |
| 19 | 11 | Apocalypto | $26,862 | -51.9% | 35 | - | $767 | $579,272 | 7 | Constantin Film | false | false |
| 20 | 15 | Hoodwinked! | $14,442 | -53.5% | 34 | -2 | $424 | $217,623 | 6 | Luna Filmverleih | false | false |
