| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Look Who's Talking | $17,878,704 | +11.9% | 1,547 | +339 | $11,557 | $33,859,891 | 2 | TriStar Pictures | false | false |
| 2 | - | Next of Kin | $6,158,710 | - | 1,358 | - | $4,535 | $6,158,710 | 1 | Warner Bros. | true | false |
| 3 | 4 | Sea of Love | $3,711,830 | -20.1% | 1,419 | -20 | $2,615 | $47,144,705 | 6 | Universal Pictures | false | false |
| 4 | 6 | Black Rain | $3,694,384 | -14.2% | 1,615 | -145 | $2,287 | $36,963,300 | 5 | Paramount Pictures | false | false |
| 5 | 5 | The Fabulous Baker Boys | $3,573,915 | -20.8% | 860 | +2 | $4,155 | $8,087,248 | 2 | Twentieth Century Fox | false | false |
| 6 | 2 | Halloween 5: The Revenge of Michael Myers | $3,567,884 | -43.7% | 1,495 | +12 | $2,386 | $9,900,837 | 2 | - | false | false |
| 7 | - | Gross Anatomy | $3,550,171 | - | 853 | - | $4,161 | $3,550,171 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 8 | 3 | An Innocent Man | $3,029,423 | -35.6% | 1,520 | -41 | $1,993 | $15,064,219 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 9 | - | Fat Man and Little Boy | $1,943,019 | - | 843 | - | $2,304 | $1,943,019 | 1 | Paramount Pictures | true | false |
| 10 | 7 | Parenthood | $1,838,845 | -14% | 1,130 | -154 | $1,627 | $89,749,450 | 13 | Universal Pictures | false | false |
| 11 | 9 | When Harry Met Sally... | $1,491,194 | -11.1% | 1,064 | -56 | $1,401 | $87,066,629 | 15 | Columbia Pictures | false | false |
| 12 | 8 | Uncle Buck | $1,449,103 | -27.9% | 1,080 | -290 | $1,341 | $60,478,366 | 10 | Universal Pictures | false | false |
| 13 | 10 | Crimes and Misdemeanors | $1,263,443 | -2.8% | 68 | +2 | $18,580 | $2,563,098 | 2 | Orion Pictures | false | false |
| 14 | 13 | Batman | $400,889 | -25.5% | 353 | -132 | $1,135 | $248,034,112 | 18 | Warner Bros. | false | false |
| 15 | - | When the Whales Came | $68,455 | - | 10 | - | $6,845 | $68,455 | 1 | Twentieth Century Fox | true | false |
