| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Rain Man | $8,852,344 | -6.8% | 1,563 | +54 | $5,663 | $90,828,249 | 7 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 2 | - | Three Fugitives | $8,139,350 | - | 1,153 | - | $7,059 | $8,139,350 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 3 | 2 | Beaches | $6,523,499 | -3.5% | 1,097 | +288 | $5,946 | $21,722,064 | 6 | Walt Disney Studios Motion Pictures | false | false |
| 4 | 3 | Twins | $5,731,845 | -6.9% | 1,659 | +18 | $3,455 | $87,447,905 | 8 | Universal Pictures | false | false |
| 5 | 7 | Mississippi Burning | $4,598,174 | +22.6% | 1,058 | +490 | $4,346 | $15,778,981 | 8 | Orion Pictures | false | false |
| 6 | 5 | Working Girl | $3,954,041 | -3.4% | 1,149 | +1 | $3,441 | $39,182,069 | 6 | Twentieth Century Fox | false | false |
| 7 | 6 | The Naked Gun: From the Files of Police Squad! | $3,558,339 | -10.6% | 1,501 | -186 | $2,370 | $69,057,615 | 9 | Paramount Pictures | false | false |
| 8 | 4 | The Accidental Tourist | $3,195,885 | -25.9% | 926 | -28 | $3,451 | $22,478,450 | 6 | Warner Bros. | false | false |
| 9 | - | Physical Evidence | $2,272,030 | - | 691 | - | $3,288 | $2,272,030 | 1 | Columbia Pictures | true | false |
| 10 | 8 | Dirty Rotten Scoundrels | $2,090,672 | -24.3% | 1,313 | -202 | $1,592 | $36,888,977 | 7 | Orion Pictures | false | false |
| 11 | 14 | Dangerous Liaisons | $1,773,219 | +38.4% | 119 | +45 | $14,901 | $5,373,067 | 6 | Warner Bros. | false | false |
| 12 | 10 | Oliver & Company | $1,238,205 | -24.6% | 1,316 | -138 | $940 | $49,607,600 | 11 | Walt Disney Studios Motion Pictures | false | false |
| 13 | - | Parents | $354,249 | - | 94 | - | $3,768 | $354,249 | 1 | Vestron Pictures | true | false |
| 14 | - | Cohen and Tate | $58,673 | - | 75 | - | $782 | $58,673 | 1 | Hemdale | true | false |
| 15 | - | Manifesto | $14,202 | - | 1 | - | $14,202 | $14,202 | 1 | Cannon Film Distributors | true | false |
