| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Old | $16,854,735 | - | 3,355 | - | $5,023 | $16,854,735 | 1 | Universal Pictures | true | false |
| 2 | - | Snake Eyes | $13,367,853 | - | 3,521 | - | $3,796 | $13,367,853 | 1 | Paramount Pictures | true | false |
| 3 | 2 | Black Widow | $11,618,898 | -55% | 4,250 | -25 | $2,733 | $154,825,581 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 4 | 1 | Space Jam: A New Legacy | $9,580,220 | -69.1% | 4,002 | +37 | $2,393 | $51,387,825 | 2 | Warner Bros. | false | false |
| 5 | 4 | F9: The Fast Saga | $4,820,075 | -37.2% | 2,850 | -518 | $1,691 | $163,516,900 | 5 | Universal Pictures | false | false |
| 6 | 3 | Escape Room: Tournament of Champions | $3,516,543 | -60% | 2,815 | - | $1,249 | $16,164,813 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | The Boss Baby: Family Business | $2,858,880 | -39.6% | 2,773 | -676 | $1,030 | $50,291,515 | 4 | Universal Pictures | false | false |
| 8 | 6 | The Forever Purge | $2,379,775 | -42.2% | 2,113 | -622 | $1,126 | $40,386,485 | 4 | Universal Pictures | false | false |
| 9 | 7 | A Quiet Place Part II | $1,205,122 | -46.2% | 1,397 | -598 | $862 | $157,478,745 | 9 | Paramount Pictures | false | false |
| 10 | 8 | Roadrunner: A Film About Anthony Bourdain | $879,630 | -55.8% | 954 | +27 | $922 | $3,751,110 | 2 | Focus Features | false | false |
| 11 | - | Joe Bell | $749,635 | - | 1,094 | - | $685 | $749,635 | 1 | Roadside Attractions | true | false |
| 12 | 10 | Pig | $587,853 | -39.5% | 588 | +36 | $999 | $2,053,785 | 2 | Neon | false | false |
| 13 | 9 | Cruella | $500,584 | -57.1% | 495 | -680 | $1,011 | $84,735,428 | 9 | Walt Disney Studios Motion Pictures | false | false |
| 14 | 11 | Hitman's Wife's Bodyguard | $316,620 | -58.7% | 476 | -558 | $665 | $37,415,729 | 6 | Lionsgate | false | false |
| 15 | 12 | Peter Rabbit 2: The Runaway | $265,465 | -56.7% | 578 | -539 | $459 | $40,001,345 | 7 | Sony Pictures Releasing | false | false |
| 16 | 13 | In the Heights | $194,223 | -47.8% | 305 | -113 | $636 | $29,515,437 | 7 | Warner Bros. | false | false |
| 17 | - | Kaamelott: First Installment | $188,000 | - | 26 | - | $7,230 | $188,000 | 1 | Paramount Pictures | true | false |
| 18 | 15 | Zola | $119,584 | -57.9% | 229 | -304 | $522 | $4,597,921 | 4 | A24 | false | false |
| 19 | 16 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $104,392 | -42.3% | 150 | -125 | $695 | $2,084,993 | 5 | Searchlight Pictures | false | false |
| 20 | - | Weathering with You | $93,984 | - | 644 | - | $145 | $7,892,727 | 80 | GKIDS | false | false |
| 21 | 17 | 12 Mighty Orphans | $59,940 | -32% | 74 | -66 | $810 | $3,434,840 | 7 | Sony Pictures Releasing | false | false |
| 22 | 18 | Spirit Untamed | $39,615 | -31.8% | 895 | -15 | $44 | $17,569,495 | 8 | Universal Pictures | false | false |
| 23 | - | CatVideoFest 2021 | $39,519 | - | 38 | - | $1,039 | $39,519 | 1 | Oscilloscope | true | false |
| 24 | - | Once I Was Engaged | $35,304 | - | 32 | - | $1,103 | $78,524 | 1 | Excel Entertainment | true | false |
| 25 | 24 | Raya and the Last Dragon | $29,571 | +93.4% | 35 | -6 | $844 | $54,658,691 | 21 | Walt Disney Studios Motion Pictures | false | false |
| 26 | 19 | Queen Bees | $27,470 | -48.9% | 83 | -40 | $330 | $1,848,018 | 7 | Gravitas Ventures | false | false |
| 27 | - | Ailey | $15,091 | - | 2 | - | $7,545 | $15,091 | 1 | Neon | true | false |
| 28 | - | Settlers | $13,045 | - | 30 | - | $434 | $13,045 | 1 | IFC Films | true | false |
| 29 | 20 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $12,166 | -59.1% | 24 | -14 | $506 | $49,475,247 | 14 | FUNimation Entertainment | false | false |
| 30 | 26 | Witnesses | $10,915 | -19% | 17 | -4 | $642 | $798,949 | 8 | Purdie Distribution | false | false |
| 31 | - | Secret Agent Dingledorf and His Trusty Dog Splat | $8,865 | - | 30 | - | $295 | $8,865 | 4 | Integrity Releasing | false | false |
| 32 | 21 | I Carry You with Me | $8,332 | -68.4% | 44 | -67 | $189 | $158,579 | 5 | Sony Pictures Classics | false | false |
| 33 | - | Mandibles | $7,346 | - | 21 | - | $349 | $7,346 | 1 | Magnet Releasing | true | false |
| 34 | - | Without Getting Killed or Caught | $6,350 | - | 1 | - | $6,350 | - | 1 | mTuckman Media | true | true |
| 35 | - | How It Ends | $5,792 | - | 10 | - | $579 | $11,860 | 2 | United Artists | false | false |
| 36 | - | Here After | $5,612 | - | 1 | - | $5,612 | $5,612 | 1 | Vertical Entertainment | true | false |
| 37 | 30 | Wrath of Man | $5,536 | -31.8% | 37 | -8 | $149 | $27,463,837 | 12 | United Artists Releasing | false | false |
| 38 | 29 | The Truffle Hunters | $5,503 | -34.7% | 12 | -3 | $458 | $504,220 | 21 | Sony Pictures Classics | false | false |
| 39 | 25 | Werewolves Within | $5,397 | -64.2% | 17 | -29 | $317 | $569,156 | 5 | IFC Films | false | false |
| 40 | 31 | The Swimming Pool 2021 Re-release | $4,947 | -24.4% | 3 | -1 | $1,649 | $134,947 | 11 | Rialto Distribution | false | false |
| 41 | 23 | The Loneliest Whale: The Search for 52 | $4,626 | -75.5% | 20 | -51 | $231 | $96,999 | 3 | Bleecker Street Media | false | false |
| 42 | 32 | The Red Circle 2021 Re-release | $4,146 | -25.8% | 4 | -1 | $1,036 | $54,729 | 5 | Rialto Pictures | false | false |
| 43 | 27 | Dream Horse | $3,930 | -59.3% | 17 | -13 | $231 | $2,862,229 | 10 | Bleecker Street Media | false | false |
| 44 | 28 | Mama Weed | $3,104 | -65.1% | 10 | -10 | $310 | $20,019 | 2 | Music Box Films | false | false |
| 45 | 35 | Can You Bring It: Bill T. Jones and D-Man in the Waters | $2,752 | +7.6% | 7 | +6 | $393 | $6,529 | 2 | Kino Lorber | false | false |
| 46 | - | No Ordinary Man | $2,513 | - | 9 | - | $279 | $7,640 | 2 | Oscilloscope | false | false |
| 47 | 33 | Rita Moreno: Just a Girl Who Decided to Go for It | $2,466 | -45.7% | 12 | -4 | $205 | $263,149 | 6 | Roadside Attractions | false | false |
| 48 | - | Victim of Love | $1,958 | - | 1 | - | $1,958 | $1,958 | 1 | Indican Pictures | true | false |
| 49 | 37 | Casanova, Last Love | $1,627 | -23.5% | 4 | -2 | $406 | $6,009 | 2 | Cohen Media Group | false | false |
| 50 | 43 | The Ladykillers 2021 Re-release | $1,404 | +591.6% | 3 | +2 | $468 | $20,215 | 8 | Rialto Pictures | false | false |
| 51 | 34 | Summer of 85 | $1,206 | -66.8% | 5 | -5 | $241 | $69,793 | 6 | Music Box Films | false | false |
| 52 | 36 | Rock Paper Scissors | $969 | -56.4% | 1 | -1 | $969 | $4,995 | 2 | Indican Pictures | false | false |
| 53 | 42 | Truman & Tennessee: An Intimate Conversation | $425 | +51.8% | 4 | +1 | $106 | $54,149 | 6 | Kino Lorber | false | false |
| 54 | 38 | The Dry | $412 | -79.5% | 3 | -2 | $137 | $362,963 | 10 | IFC Films | false | false |
| 55 | 39 | Undine | $198 | -88.2% | 2 | -2 | $99 | $78,406 | 8 | IFC Films | false | false |
| 56 | - | Together Together | $138 | - | 2 | - | $69 | $1,436,474 | 14 | Bleecker Street Media | false | false |
| 57 | - | Mission Stories | $96 | - | 1 | - | $96 | $86,942 | 12 | Excel Entertainment | false | false |
| 58 | 44 | The Perfect Candidate | $56 | +19.1% | 1 | - | $56 | $28,720 | 11 | Music Box Films | false | false |
| 59 | 40 | Shiva Baby | $32 | -96.9% | 1 | -2 | $32 | $156,584 | 17 | Utopia | false | false |
