| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Black Widow | $80,366,312 | - | 4,160 | - | $19,318 | $80,366,312 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 2 | 1 | F9: The Fast Saga | $11,436,785 | -50.3% | 3,649 | -554 | $3,134 | $141,882,510 | 3 | Universal Pictures | false | false |
| 3 | 2 | The Boss Baby: Family Business | $8,876,235 | -44.5% | 3,688 | +44 | $2,406 | $34,922,745 | 2 | Universal Pictures | false | false |
| 4 | 3 | The Forever Purge | $7,144,485 | -43.1% | 3,058 | +7 | $2,336 | $27,879,400 | 2 | Universal Pictures | false | false |
| 5 | 4 | A Quiet Place Part II | $3,155,430 | -23.1% | 2,359 | -467 | $1,337 | $150,849,725 | 7 | Paramount Pictures | false | false |
| 6 | 6 | Cruella | $2,370,111 | -0.7% | 1,875 | -505 | $1,264 | $80,936,776 | 7 | Walt Disney Studios Motion Pictures | false | false |
| 7 | 5 | Hitman's Wife's Bodyguard | $1,630,927 | -45.7% | 1,904 | -1,457 | $856 | $35,040,774 | 4 | Lionsgate | false | false |
| 8 | 7 | Peter Rabbit 2: The Runaway | $1,262,805 | -42.3% | 1,958 | -996 | $644 | $37,712,809 | 5 | Sony Pictures Releasing | false | false |
| 9 | 8 | The Conjuring: The Devil Made Me Do It | $655,324 | -48% | 667 | -1,049 | $982 | $63,833,077 | 6 | Warner Bros. | false | false |
| 10 | 9 | Zola | $636,564 | -47% | 1,401 | -67 | $454 | $3,548,127 | 2 | A24 | false | false |
| 11 | 10 | In the Heights | $612,520 | -48.3% | 788 | -617 | $777 | $28,300,072 | 5 | Warner Bros. | false | false |
| 12 | 11 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $377,634 | -41.7% | 752 | - | $502 | $1,430,158 | 3 | Searchlight Pictures | false | false |
| 13 | 12 | Spirit Untamed | $140,020 | -60.4% | 968 | -328 | $144 | $17,344,785 | 6 | Universal Pictures | false | false |
| 14 | 14 | 12 Mighty Orphans | $136,569 | -33.3% | 185 | -153 | $738 | $3,161,579 | 5 | Sony Pictures Releasing | false | false |
| 15 | 17 | Queen Bees | $73,500 | -10.3% | 163 | -7 | $450 | $1,674,921 | 5 | Gravitas Ventures | false | false |
| 16 | 15 | The House Next Door: Meet the Blacks 2 | $41,997 | -51.5% | 44 | -72 | $954 | $2,834,271 | 5 | Hidden Empire Film Group (HEFG) | false | false |
| 17 | - | The Loneliest Whale: The Search for 52 | $41,131 | - | - | - | - | $41,131 | 1 | Bleecker Street Media | true | false |
| 18 | 18 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $34,980 | -40.3% | 42 | -39 | $832 | $49,376,322 | 12 | FUNimation Entertainment | false | false |
| 19 | 20 | Raya and the Last Dragon | $33,591 | -21% | 55 | -20 | $610 | $54,593,490 | 19 | Walt Disney Studios Motion Pictures | false | false |
| 20 | 24 | I Carry You with Me | $30,857 | +42.7% | 57 | +33 | $541 | $92,646 | 3 | Sony Pictures Classics | false | false |
| 21 | 16 | Werewolves Within | $25,023 | -70.9% | 63 | -146 | $397 | $523,757 | 3 | IFC Films | false | false |
| 22 | - | Summertime | $21,490 | - | 2 | - | $10,745 | $21,490 | 1 | Good Deed Entertainment | true | false |
| 23 | 21 | Witnesses | $20,118 | -33.6% | 26 | -7 | $773 | $734,586 | 6 | Purdie Distribution | false | false |
| 24 | 26 | Dream Horse | $15,800 | +5.4% | 44 | -29 | $359 | $2,833,574 | 8 | Bleecker Street Media | false | false |
| 25 | 19 | Wrath of Man | $12,435 | -77.9% | 50 | -32 | $248 | $27,438,906 | 10 | United Artists Releasing | false | false |
| 26 | 27 | The Truffle Hunters | $11,496 | -17% | 18 | -7 | $638 | $478,606 | 19 | Sony Pictures Classics | false | false |
| 27 | 34 | The Red Circle 2021 Re-release | $5,942 | +0.3% | 4 | +3 | $1,485 | $34,572 | 3 | Rialto Pictures | false | false |
| 28 | 25 | Rita Moreno: Just a Girl Who Decided to Go for It | $5,838 | -62.7% | 23 | -33 | $253 | $249,689 | 4 | Roadside Attractions | false | false |
| 29 | 32 | Summer of 85 | $5,108 | -35.8% | 13 | -6 | $392 | $60,097 | 4 | Music Box Films | false | false |
| 30 | 29 | The God Committee | $4,838 | -60.5% | 25 | -3 | $193 | $29,301 | 2 | Vertical Entertainment | false | false |
| 31 | 33 | The Swimming Pool 2021 Re-release | $3,813 | -44.5% | 8 | -1 | $476 | $117,673 | 9 | Rialto Distribution | false | false |
| 32 | 35 | The Dry | $3,623 | -22.4% | 7 | - | $517 | $358,327 | 8 | IFC Films | false | false |
| 33 | - | Scales | $3,090 | - | 2 | - | $1,545 | $3,090 | 1 | Variance Films | true | false |
| 34 | - | Shiva Baby | $2,158 | - | 4 | - | $539 | $153,208 | 15 | Utopia | false | false |
| 35 | 30 | First Date | $2,108 | -76.3% | 13 | -8 | $162 | $15,056 | 2 | Magnolia Pictures | false | false |
| 36 | 37 | Undine | $2,082 | +5.1% | 7 | +1 | $297 | $75,880 | 6 | IFC Films | false | false |
| 37 | - | A Soldier's Story 2: Return from the Dead | $1,724 | - | 2 | - | $862 | $20,608 | 3 | Indican Pictures | false | false |
| 38 | 36 | The Ladykillers 2021 Re-release | $1,094 | -56.7% | 3 | +2 | $364 | $18,011 | 6 | Rialto Pictures | false | false |
| 39 | 38 | Censor | $1,054 | -46.7% | 3 | -1 | $351 | $88,048 | 5 | Magnolia Pictures | false | false |
| 40 | 40 | About Endlessness | $202 | -85.8% | 1 | - | $202 | $48,493 | 11 | Magnolia Pictures | false | false |
| 41 | - | The Perfect Candidate | $114 | - | 1 | - | $114 | $28,617 | 9 | Music Box Films | false | false |
