| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Smurfs | $2,649,648 | - | 458 | - | $5,785 | $3,634,929 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Johnny English Reborn | $2,628,344 | - | 293 | - | $8,970 | $2,628,344 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 2 | Horrible Bosses | $928,424 | -40% | 275 | -62 | $3,376 | $10,460,229 | 4 | Warner Bros. | false | false |
| 4 | 3 | Red Dog | $846,940 | -35.3% | 259 | -9 | $3,270 | $16,607,518 | 7 | Roadshow Films | false | false |
| 5 | 4 | The Help | $830,872 | -33.5% | 221 | -59 | $3,759 | $4,895,129 | 3 | Walt Disney Pictures | false | false |
| 6 | 1 | Zookeeper | $789,799 | -58% | 249 | -3 | $3,171 | $3,130,100 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | The Change-Up | $681,416 | -41.8% | 220 | - | $3,097 | $2,255,718 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | - | Fright Night | $531,331 | - | 167 | - | $3,181 | $543,845 | 1 | Walt Disney Pictures | true | false |
| 9 | 6 | Final Destination 5 | $233,266 | -62.2% | 114 | -45 | $2,046 | $2,443,764 | 3 | Warner Bros. | false | false |
| 10 | - | The Eye of the Storm | $203,445 | - | 18 | - | $11,302 | $203,445 | 1 | Paramount Pictures International | true | false |
| 11 | 12 | The Guard | $170,650 | -39.3% | 55 | -10 | $3,102 | $1,462,687 | 4 | Paramount Pictures International | false | false |
| 12 | 8 | Friends with Benefits | $163,931 | -64.4% | 118 | -93 | $1,389 | $7,408,843 | 5 | Sony Pictures Releasing | false | false |
| 13 | 9 | One Day | $151,936 | -62.1% | 106 | -57 | $1,433 | $1,544,513 | 3 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | Rise of the Planet of the Apes | $104,481 | -68.2% | 74 | -64 | $1,411 | $15,001,863 | 7 | 20th Century Fox International | false | false |
| 15 | 13 | Harry Potter and the Deathly Hallows: Part 2 | $95,731 | -48.1% | 53 | -29 | $1,806 | $54,319,291 | 10 | Warner Bros. | false | false |
| 16 | - | The Survival of Humanity | $94,692 | - | 98 | - | $966 | $133,971 | - | Roadshow Films | - | false |
| 17 | 11 | Cowboys & Aliens | $86,066 | -73.5% | 67 | -135 | $1,284 | $5,536,688 | 5 | Paramount Pictures International | false | false |
| 18 | 17 | Submarine | $66,456 | -28% | 18 | - | $3,692 | $219,292 | 2 | Madman Entertainment | false | false |
| 19 | 14 | Jane Eyre | $61,906 | -57.3% | 49 | -33 | $1,263 | $3,303,178 | 6 | Universal Pictures International (UPI) | false | false |
| 20 | 15 | Beginners | $43,704 | -54.3% | 22 | -4 | $1,986 | $616,716 | 4 | Hopscotch Films | false | false |
