| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Smurfs | $426,491 | -38.5% | 166 | -6 | $2,569 | $7,658,157 | 5 | Sony Pictures Releasing | false | false |
| 2 | 2 | Rise of the Planet of the Apes | $332,547 | -43.2% | 107 | +2 | $3,107 | $2,332,474 | 3 | Warner Bros. | false | false |
| 3 | 3 | Final Destination 5 | $316,742 | -45.8% | 68 | - | $4,657 | $1,104,279 | 2 | Warner Bros. | false | false |
| 4 | 4 | Harry Potter and the Deathly Hallows: Part 2 | $235,519 | -45.2% | 157 | -12 | $1,500 | $17,685,390 | 8 | Warner Bros. | false | false |
| 5 | 5 | Cowboys & Aliens | $178,275 | -51.5% | 78 | - | $2,285 | $754,066 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 6 | Horrible Bosses | $158,371 | -30.1% | 76 | -6 | $2,083 | $2,680,368 | 6 | Warner Bros. | false | false |
| 7 | - | Glee: The 3D Concert Movie | $155,342 | - | 49 | - | $3,170 | $161,798 | 1 | Warner Bros. | true | false |
| 8 | 7 | Mr. Popper's Penguins | $131,529 | -40.1% | 99 | - | $1,328 | $1,476,611 | 4 | Warner Bros. | false | false |
| 9 | - | Flypaper | $100,435 | - | 20 | - | $5,021 | $142,714 | 1 | Independent Films | true | false |
| 10 | 8 | Super 8 | $83,216 | -52% | 85 | -2 | $979 | $1,549,103 | 4 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | Melancholia | $74,300 | -41.7% | 22 | +1 | $3,377 | $271,651 | 2 | Wild Bunch Distribution | false | false |
| 12 | 9 | Cars 2 | $69,838 | -45.4% | 140 | -10 | $498 | $6,215,264 | 9 | Walt Disney Pictures | false | false |
| 13 | 12 | Honey 2 | $41,374 | -43.4% | 29 | -1 | $1,426 | $801,933 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 11 | Monte Carlo | $40,864 | -48.1% | 49 | - | $833 | $1,121,657 | 6 | Warner Bros. | false | false |
| 15 | 13 | Bridesmaids | $29,200 | -49.7% | 39 | -6 | $748 | $2,636,881 | 9 | Universal Pictures International (UPI) | false | false |
| 16 | 17 | Larry Crowne | $25,026 | -39.9% | 30 | -3 | $834 | $463,334 | 5 | Entertainment One | false | false |
| 17 | 14 | A Separation | $23,222 | -49.6% | 14 | +1 | $1,658 | $274,745 | 4 | Cinéart | false | false |
| 18 | - | El Bulli: Cooking in Progress | $23,007 | - | 20 | - | $1,150 | $31,468 | 1 | N/A | true | false |
| 19 | 16 | Kung Fu Panda 2 | $21,202 | -49.2% | 66 | -7 | $321 | $5,392,086 | 12 | Universal Pictures International (UPI) | false | false |
| 20 | - | The Future | $19,031 | - | 11 | - | $1,730 | $22,259 | 1 | Cinemien | true | false |
