| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Horrible Bosses | $3,355,005 | - | 339 | - | $9,896 | $3,444,351 | 1 | Warner Bros. | true | false |
| 2 | 2 | Red Dog | $2,051,810 | -11.8% | 257 | +4 | $7,983 | $11,156,524 | 4 | Roadshow Films | false | false |
| 3 | 1 | Friends with Benefits | $1,474,708 | -43% | 251 | +4 | $5,875 | $5,284,502 | 2 | Sony Pictures Releasing | false | false |
| 4 | 3 | Cowboys & Aliens | $1,083,002 | -49% | 235 | -31 | $4,608 | $3,939,990 | 2 | Paramount Pictures International | false | false |
| 5 | 4 | Rise of the Planet of the Apes | $922,358 | -46.8% | 238 | -54 | $3,875 | $13,790,007 | 4 | 20th Century Fox International | false | false |
| 6 | 5 | Green Lantern | $588,301 | -54.3% | 361 | +158 | $1,629 | $6,433,388 | 3 | Warner Bros. | false | false |
| 7 | 6 | Harry Potter and the Deathly Hallows: Part 2 | $470,276 | -40.3% | 179 | -61 | $2,627 | $54,470,660 | 7 | Warner Bros. | false | false |
| 8 | 8 | Jane Eyre | $362,398 | -40.4% | 150 | -1 | $2,415 | $2,638,376 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | - | Priest | $330,032 | - | 104 | - | $3,173 | $330,032 | 1 | Sony Pictures Releasing | true | false |
| 10 | 7 | Conan the Barbarian | $323,340 | -49.9% | 213 | +10 | $1,518 | $1,229,103 | 2 | Roadshow Films | false | false |
| 11 | - | The Guard | $313,952 | - | 49 | - | $6,407 | $313,952 | 1 | Paramount Pictures International | true | false |
| 12 | - | Beginners | $150,614 | - | 25 | - | $6,024 | $197,719 | 1 | Hopscotch Films | true | false |
| 13 | 11 | Senna | $138,206 | -42.7% | 47 | -1 | $2,940 | $1,056,149 | 3 | Universal Pictures International (UPI) | false | false |
| 14 | 9 | Glee: The 3D Concert Movie | $110,802 | -80.4% | 224 | +25 | $494 | $2,099,780 | 3 | 20th Century Fox International | false | false |
| 15 | 10 | Captain America: The First Avenger | $107,216 | -68.3% | 104 | -118 | $1,030 | $10,952,682 | 5 | Paramount Pictures International | false | false |
| 16 | 13 | Win Win | $52,606 | -59.6% | 65 | +60 | $809 | $274,644 | 2 | 20th Century Fox International | false | false |
| 17 | 16 | Pina | $49,484 | -0.5% | 10 | - | $4,948 | $137,553 | 2 | Hopscotch Films | false | false |
| 18 | 12 | Bad Teacher | $42,942 | -76.6% | 40 | -81 | $1,073 | $8,746,982 | 6 | Sony Pictures Releasing | false | false |
| 19 | 14 | Mr. Popper's Penguins | $35,074 | -59.4% | 62 | -45 | $565 | $13,061,490 | 9 | 20th Century Fox International | false | false |
| 20 | 15 | Bridesmaids | $29,058 | -61.6% | 27 | -21 | $1,076 | $28,688,657 | 12 | Universal Pictures International (UPI) | false | false |
