| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: On Stranger Tides | $52,496 | -30.5% | 8 | -1 | $6,562 | $421,121 | 4 | Walt Disney Pictures | false | false |
| 2 | 2 | The Hangover Part II | $39,755 | -29.9% | 7 | -1 | $5,679 | $177,004 | 3 | Warner Bros. | false | false |
| 3 | 3 | Kung Fu Panda 2 | $36,529 | -27.8% | 9 | - | $4,058 | $93,835 | 2 | United International Pictures | false | false |
| 4 | 4 | X-Men: First Class | $33,034 | -14.5% | 9 | - | $3,670 | $82,176 | 2 | 20th Century Fox International | false | false |
| 5 | 5 | Fast Five | $18,182 | -24.9% | 9 | -1 | $2,020 | $345,157 | 6 | United International Pictures | false | false |
| 6 | - | Something Borrowed | $16,899 | - | 5 | - | $3,379 | $16,899 | 1 | N/A | true | false |
| 7 | 6 | Rio | $9,443 | -29.1% | 3 | -3 | $3,147 | $204,409 | 7 | 20th Century Fox International | false | false |
| 8 | - | The Hole | $8,573 | - | 3 | - | $2,857 | $8,573 | 1 | N/A | true | false |
| 9 | 7 | Priest | $7,504 | -30.7% | 7 | - | $1,072 | $39,767 | 3 | Sony Pictures Releasing | false | false |
| 10 | 8 | Water for Elephants | $3,440 | -54.3% | 2 | -3 | $1,720 | $27,025 | 3 | 20th Century Fox International | false | false |
| 11 | 9 | Scream 4 | $2,707 | -57.8% | 2 | -1 | $1,353 | $110,488 | 7 | N/A | false | false |
| 12 | 12 | The Rite | $1,660 | +9.3% | 3 | - | $553 | $161,938 | 14 | Warner Bros. | false | false |
| 13 | 10 | Just Go with It | $882 | -70.9% | 1 | -2 | $882 | $121,770 | 16 | Sony Pictures Releasing | false | false |
| 14 | 18 | The Adjustment Bureau | $468 | +78.6% | 2 | - | $234 | $66,264 | 9 | United International Pictures | false | false |
| 15 | 15 | Hall Pass | $427 | -32.6% | 1 | -1 | $427 | $57,604 | 9 | Warner Bros. | false | false |
| 16 | 11 | Thor | $413 | -73.9% | 2 | - | $206 | $154,925 | 7 | United International Pictures | false | false |
| 17 | 16 | Paul | $231 | -62.8% | 3 | -1 | $77 | $19,556 | 5 | United International Pictures | false | false |
| 18 | 17 | No Strings Attached | $135 | -69.9% | 1 | -1 | $135 | $88,387 | 11 | United International Pictures | false | false |
| 19 | 19 | Rango | $98 | -52.4% | 2 | -1 | $49 | $39,032 | 9 | United International Pictures | false | false |
| 20 | 13 | Unknown | $13 | -98.9% | 1 | -1 | $13 | $132,107 | 12 | Warner Bros. | false | false |
