| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: On Stranger Tides | $75,561 | -24.8% | 9 | - | $8,395 | $353,835 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | The Hangover Part II | $56,743 | +6.9% | 8 | - | $7,092 | $125,672 | 2 | Warner Bros. | false | false |
| 3 | - | Kung Fu Panda 2 | $50,591 | - | 9 | - | $5,621 | $50,591 | 1 | United International Pictures | true | false |
| 4 | - | X-Men: First Class | $38,633 | - | 9 | - | $4,292 | $38,633 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Fast Five | $24,211 | -36.3% | 10 | - | $2,421 | $320,564 | 5 | United International Pictures | false | false |
| 6 | 4 | Rio | $13,319 | -24.7% | 6 | -2 | $2,219 | $192,524 | 6 | 20th Century Fox International | false | false |
| 7 | 5 | Priest | $10,828 | -28.6% | 7 | -1 | $1,546 | $29,896 | 2 | Sony Pictures Releasing | false | false |
| 8 | 7 | Water for Elephants | $7,526 | -33.5% | 5 | - | $1,505 | $21,549 | 2 | 20th Century Fox International | false | false |
| 9 | 6 | Scream 4 | $6,421 | -55.4% | 3 | -2 | $2,140 | $106,038 | 6 | N/A | false | false |
| 10 | 11 | Just Go with It | $3,026 | -10.8% | 3 | - | $1,008 | $120,133 | 15 | Sony Pictures Releasing | false | false |
| 11 | 8 | Thor | $1,582 | -84.1% | 2 | -5 | $791 | $154,161 | 6 | United International Pictures | false | false |
| 12 | 9 | The Rite | $1,519 | -67.7% | 3 | - | $506 | $159,606 | 13 | Warner Bros. | false | false |
| 13 | 16 | Unknown | $1,167 | -14.1% | 2 | +1 | $583 | $131,529 | 11 | Warner Bros. | false | false |
| 14 | 10 | Tomorrow, When the War Began | $816 | -82% | 2 | -3 | $408 | $6,598 | 2 | N/A | false | false |
| 15 | 12 | Hall Pass | $634 | -67.4% | 2 | - | $317 | $57,062 | 8 | Warner Bros. | false | false |
| 16 | 15 | Paul | $621 | -56.4% | 4 | - | $155 | $19,206 | 4 | United International Pictures | false | false |
| 17 | 20 | No Strings Attached | $448 | -39% | 2 | -1 | $224 | $88,253 | 10 | United International Pictures | false | false |
| 18 | 19 | The Adjustment Bureau | $262 | -71.8% | 2 | -2 | $131 | $65,711 | 8 | United International Pictures | false | false |
| 19 | 22 | Rango | $206 | -65.1% | 3 | - | $68 | $38,816 | 8 | United International Pictures | false | false |
| 20 | 18 | Ironclad | $186 | -80.6% | 1 | -1 | $186 | $26,406 | 4 | N/A | false | false |
| 21 | 21 | Red Riding Hood | $119 | -81.1% | 1 | - | $119 | $32,990 | 7 | Warner Bros. | false | false |
