| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Pirates of the Caribbean: On Stranger Tides | $1,120,409 | - | 87 | - | $12,878 | $1,120,409 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Fast Five | $238,692 | -50.6% | 54 | - | $4,420 | $1,750,584 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | Thor | $82,560 | -74.3% | 107 | +5 | $771 | $1,918,106 | 4 | Paramount Pictures International | false | false |
| 4 | 3 | Gnomeo & Juliet | $63,501 | -64.8% | 56 | - | $1,133 | $534,119 | 3 | N/A | false | false |
| 5 | - | Stone | $45,200 | - | 12 | - | $3,766 | $45,200 | 1 | N/A | true | false |
| 6 | 4 | Rio | $42,210 | -64.9% | 78 | - | $541 | $3,751,425 | 7 | 20th Century Fox International | false | false |
| 7 | - | Birds of America | $19,367 | - | 20 | - | $968 | $113,259 | 2 | N/A | false | false |
| 8 | 6 | Solitary Man | $13,698 | -66.6% | 13 | - | $1,053 | $70,620 | 2 | N/A | false | false |
| 9 | 8 | Water for Elephants | $11,255 | -64.3% | 20 | - | $562 | $214,359 | 4 | 20th Century Fox International | false | false |
| 10 | 7 | Hop | $8,579 | -78.4% | 52 | - | $164 | $757,699 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | 5 | Arthur | $8,341 | -81.4% | 26 | - | $320 | $160,390 | 3 | Warner Bros. | false | false |
| 12 | 12 | I Spit on Your Grave | $6,327 | -65.1% | 40 | - | $158 | $218,625 | 4 | N/A | false | false |
| 13 | 10 | Red Riding Hood | $5,907 | -74.3% | 25 | - | $236 | $429,646 | 5 | Warner Bros. | false | false |
| 14 | 11 | Coming Soon | $5,003 | -76.3% | 20 | - | $250 | $184,191 | 7 | N/A | false | false |
| 15 | 9 | Winnie the Pooh | $4,804 | -80.5% | 22 | - | $218 | $78,094 | 3 | Walt Disney Pictures | false | false |
| 16 | 14 | Qué pena tu vida | $3,929 | -61.3% | 20 | - | $196 | $91,959 | 6 | N/A | false | false |
| 17 | 27 | Big Mommas: Like Father, Like Son | $1,563 | +412.5% | 31 | - | $50 | $642,257 | 10 | 20th Century Fox International | false | false |
| 18 | 21 | Hall Pass | $1,505 | -45.6% | 25 | - | $60 | $210,124 | 9 | Warner Bros. | false | false |
| 19 | 15 | Just Go with It | $1,282 | -87.3% | 3 | -3 | $427 | $995,461 | 8 | Sony Pictures Releasing | false | false |
| 20 | 13 | Nowhere Boy | $1,067 | -89.6% | 12 | - | $88 | $37,306 | 3 | N/A | false | false |
| 21 | 22 | Agora | $668 | -63.6% | 18 | - | $37 | $144,257 | 7 | N/A | false | false |
| 22 | 20 | The Invisible Eye | $622 | -79.5% | 4 | - | $155 | $5,083 | 2 | N/A | false | false |
| 23 | 26 | The Burning Plain | $317 | -9.2% | 10 | - | $31 | $36,613 | 5 | N/A | false | false |
| 24 | 18 | How Do You Know | $294 | -92.1% | 1 | -3 | $294 | $168,868 | 15 | Sony Pictures Releasing | false | false |
| 25 | 25 | The Messenger | $255 | -45.4% | 7 | - | $36 | $35,176 | 8 | N/A | false | false |
| 26 | 16 | Drive Angry | $206 | -96.4% | 22 | - | $9 | $255,370 | 8 | Warner Bros. | false | false |
