Venezuelan 2010 Weekend 53
December 31-January 2, 2011
| Rank | LW | Release | Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | TRON: Legacy | $225,720 | -35.3% | 64 | -3 | $3,526 | $2,021,033 | 3 | United International Pictures |
| 2 | 2 | Tangled | $217,608 | -21.9% | 67 | -4 | $3,247 | $4,846,314 | 6 | Walt Disney Pictures |
| 3 | 3 | Megamind | $127,168 | -10.8% | 67 | -4 | $1,898 | $1,754,123 | 4 | United International Pictures |
| 4 | 4 | The Spy Next Door 2010 Re-release | $116,682 | +7.8% | 30 | - | $3,889 | $400,837 | 2 | N/A |
| 5 | 5 | Harry Potter and the Deathly Hallows: Part 1 | $63,989 | -35.8% | 63 | -4 | $1,015 | $4,444,865 | 7 | Warner Bros. |
| 6 | 6 | The Zero Hour | $62,239 | -15.7% | 38 | - | $1,637 | $3,092,011 | 13 | N/A |
| 7 | 7 | The Last Exorcism | $39,603 | -39.6% | 23 | -4 | $1,721 | $550,102 | 4 | N/A |
| 8 | 8 | Charlie St. Cloud | $33,112 | -26.2% | 20 | -1 | $1,655 | $159,530 | 2 | United International Pictures |
| 9 | 9 | 9 meses | $26,151 | -13.3% | 16 | - | $1,634 | $708,418 | 8 | N/A |
| 10 | 10 | The Social Network | $23,487 | +18.8% | 24 | -1 | $978 | $489,419 | 5 | Sony Pictures Releasing |
| 11 | 11 | Takers 2010 Re-release | $13,409 | +28.5% | 20 | +6 | $670 | $155,208 | 4 | Sony Pictures Releasing |
| 12 | 12 | Muerte en alto contraste | $6,532 | -14.1% | 8 | +1 | $816 | $241,881 | 6 | N/A |
| 13 | 13 | Life as We Know It | $2,220 | -47.4% | 4 | -3 | $555 | $957,850 | 8 | Warner Bros. |
| 14 | 14 | Four Minutes 2010 Re-release | $1,770 | -2.7% | 4 | +1 | $442 | $16,985 | 3 | N/A |
| 15 | 16 | Tinker Bell and the Great Fairy Rescue | $491 | -25.7% | 3 | -2 | $163 | $343,216 | 15 | Walt Disney Pictures |
| 16 | 15 | I Served the King of England 2010 Re-release | $294 | -64.9% | 1 | - | $294 | $17,174 | 4 | N/A |
