Domestic 2010 Weekend 48
November 25-28, 2010 - Thanksgiving 4-Day weekend (US)
Key:New This Week
| Rank | LW | Release | Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | - | Harry Potter and the Deathly Hallows: Part 1 | $60,563,081 | - | 4,125 | - | $14,681 | $219,056,129 | 2 | Warner Bros. |
| 2 | - | Tangled | $56,837,104 | - | 3,603 | - | $15,774 | $68,706,298 | 1 | Walt Disney Studios Motion Pictures |
| 3 | - | Megamind | $14,610,896 | - | 3,411 | - | $4,283 | $130,218,934 | 4 | DreamWorks |
| 4 | - | Burlesque | $14,434,601 | - | 3,037 | - | $4,752 | $17,300,213 | 1 | Screen Gems |
| 5 | - | Unstoppable | $13,979,767 | - | 3,261 | - | $4,286 | $60,442,621 | 3 | Twentieth Century Fox |
| 6 | - | Love & Other Drugs | $11,662,043 | - | 2,455 | - | $4,750 | $13,901,532 | 1 | Twentieth Century Fox |
| 7 | - | Faster | $10,401,651 | - | 2,454 | - | $4,238 | $12,002,840 | 1 | CBS Films |
| 8 | - | Due Date | $8,890,085 | - | 2,733 | - | $3,252 | $84,861,008 | 4 | Warner Bros. |
| 9 | - | The Next Three Days | $5,693,191 | - | 2,564 | - | $2,220 | $14,392,072 | 2 | Lionsgate |
| 10 | - | Morning Glory | $4,747,296 | - | 2,441 | - | $1,944 | $26,340,571 | 3 | Paramount Pictures |
| 11 | - | 127 Hours | $2,010,584 | - | 293 | - | $6,862 | $4,420,168 | 4 | - |
| 12 | - | Fair Game | $1,779,451 | - | 396 | - | $4,493 | $5,958,797 | 4 | Summit Entertainment |
| 13 | - | RED | $1,687,412 | - | 914 | - | $1,846 | $86,117,412 | 7 | Summit Entertainment |
| 14 | - | For Colored Girls | $1,559,757 | - | 605 | - | $2,578 | $36,564,364 | 4 | Lionsgate |
| 15 | - | Skyline | $1,395,455 | - | 1,300 | - | $1,073 | $20,215,790 | 3 | Universal Pictures |
| 16 | - | The Social Network | $838,339 | - | 291 | - | $2,880 | $90,423,986 | 9 | Sony Pictures Releasing |
| 17 | - | Secretariat | $789,588 | - | 501 | - | $1,576 | $57,547,263 | 8 | Walt Disney Studios Motion Pictures |
| 18 | - | Despicable Me | $401,660 | - | 266 | - | $1,510 | $249,724,650 | 21 | Universal Pictures |
| 19 | - | The Town | $358,288 | - | 318 | - | $1,126 | $91,429,625 | 11 | Warner Bros. |
| 20 | - | The King's Speech | $355,450 | - | 4 | - | $88,862 | $355,450 | 1 | The Weinstein Company |
| 21 | - | Break Ke Baad | $270,587 | - | 85 | - | $3,183 | $310,329 | 1 | Reliance Big Pictures |
| 22 | - | Paranormal Activity 2 | $262,748 | - | 279 | - | $941 | $84,105,661 | 6 | Paramount Pictures |
| 23 | - | Guzaarish | $261,455 | - | 108 | - | $2,420 | $890,678 | 2 | UTV Motion Pictures |
| 24 | - | Easy A | $225,824 | - | 251 | - | $899 | $57,920,786 | 11 | Screen Gems |
| 25 | - | Jackass 3D | $222,830 | - | 183 | - | $1,217 | $116,563,800 | 7 | Paramount Pictures |
| 26 | - | Hubble | $217,217 | - | 57 | - | $3,810 | $18,722,359 | 37 | Warner Bros. |
| 27 | - | Life as We Know It | $187,703 | - | 301 | - | $623 | $51,980,019 | 8 | Warner Bros. |
| 28 | - | Alpha and Omega | $183,934 | - | 228 | - | $806 | $25,077,977 | 11 | Lionsgate |
| 29 | - | Saw 3D | $156,780 | - | 145 | - | $1,081 | $45,670,855 | 5 | Lionsgate |
| 30 | - | Inception | $143,301 | - | 164 | - | $873 | $292,277,755 | 20 | Warner Bros. |
| 31 | - | Hereafter | $95,078 | - | 313 | - | $303 | $32,361,357 | 7 | Warner Bros. |
| 32 | - | Conviction 2010 Re-release | $82,813 | - | 88 | - | $941 | $6,571,027 | 7 | - |
| 33 | - | Legend of the Guardians: The Owls of Ga'Hoole | $78,509 | - | 130 | - | $603 | $54,579,493 | 10 | Warner Bros. |
| 34 | - | The Nutcracker: The Untold Story | $77,520 | - | 42 | - | $1,845 | $87,539 | 1 | Freestyle Releasing |
| 35 | - | Waiting for Superman | $66,730 | - | 69 | - | $967 | $6,252,794 | 10 | Paramount Vantage |
| 36 | - | Under the Sea 3D | $56,940 | - | 13 | - | $4,380 | $24,947,793 | 94 | Warner Bros. |
| 37 | - | Wall Street: Money Never Sleeps | $52,748 | - | 124 | - | $425 | $52,401,170 | 10 | Twentieth Century Fox |
| 38 | - | Stone | $18,367 | - | 23 | - | $798 | $1,742,065 | 8 | Overture Films |
| 39 | - | Nowhere Boy | $17,653 | - | 40 | - | $441 | $1,422,277 | 8 | The Weinstein Company |
| 40 | - | Catfish | $9,360 | - | 9 | - | $1,040 | $3,234,373 | 11 | Rogue Pictures |
| 41 | - | Wild Target | $8,740 | - | 6 | - | $1,456 | $76,417 | 5 | Freestyle Releasing |
| 42 | - | Let Me In | $7,636 | - | 31 | - | $246 | $12,129,485 | 9 | Overture Films |
| 43 | - | Jack Goes Boating | $5,092 | - | 9 | - | $565 | $528,845 | 11 | Overture Films |
| 44 | - | The Tillman Story | $3,125 | - | 13 | - | $240 | $792,925 | 15 | The Weinstein Company |
| 45 | - | It's Kind of a Funny Story | $2,999 | - | 46 | - | $65 | $6,363,628 | - | Focus Features |
| 46 | - | Cool It | $1,110 | - | 43 | - | $25 | $57,950 | 3 | Roadside Attractions |
| 47 | - | Winter's Bone | $646 | - | 2 | - | $323 | $6,226,365 | 25 | Roadside Attractions |
| 48 | - | I Spit on Your Grave | $138 | - | 1 | - | $138 | $93,051 | - | Anchor Bay Films |
| 49 | - | Violet Tendencies | $93 | - | 1 | - | $93 | $11,565 | - | Embrem Entertainment |
