| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Liefling | $276,820 | - | 95 | - | $2,913 | $276,820 | 1 | Indigenous Film Distribution | true | false |
| 2 | - | RED | $142,258 | - | 45 | - | $3,161 | $142,258 | 1 | NuMetro Distribution | true | false |
| 3 | 1 | Unstoppable | $121,720 | -25.2% | 61 | +1 | $1,995 | $365,176 | 2 | NuMetro Distribution | false | false |
| 4 | - | Jackass 3D | $99,722 | - | 34 | - | $2,933 | $99,722 | 1 | United International Pictures | true | false |
| 5 | 2 | Life as We Know It | $97,061 | -21.1% | 62 | -6 | $1,565 | $772,169 | 4 | NuMetro Distribution | false | false |
| 6 | 3 | Despicable Me | $62,906 | -19% | 48 | -15 | $1,310 | $2,029,444 | 8 | United International Pictures | false | false |
| 7 | 4 | The Social Network | $41,197 | -32.4% | 26 | -14 | $1,584 | $272,612 | 3 | Ster-Kinekor Pictures | false | false |
| 8 | 6 | Eat Pray Love | $39,563 | -24.3% | 45 | -19 | $879 | $1,668,724 | 7 | Sony Pictures Releasing | false | false |
| 9 | 7 | You Again | $39,360 | -16.2% | 28 | -2 | $1,405 | $195,894 | 3 | Ster-Kinekor Pictures | false | false |
| 10 | 9 | Takers 2010 Re-release | $29,227 | -22.9% | 34 | -4 | $859 | $329,131 | 4 | Ster-Kinekor Pictures | false | false |
| 11 | 14 | The Girl with the Dragon Tattoo | $27,100 | +36.5% | 12 | - | $2,258 | $234,056 | 6 | NuMetro Distribution | false | false |
| 12 | - | Battle for Terra | $23,928 | - | 21 | - | $1,139 | $23,928 | 1 | Ster-Kinekor Pictures | true | false |
| 13 | 12 | The Girl Who Played with Fire | $19,476 | -16.6% | 11 | -3 | $1,770 | $102,723 | 3 | NuMetro Distribution | false | false |
| 14 | 11 | The Switch | $19,227 | -18% | 27 | -6 | $712 | $526,552 | 6 | NuMetro Distribution | false | false |
| 15 | 10 | The Other Guys | $15,346 | -36.9% | 21 | -13 | $730 | $1,146,755 | 9 | Sony Pictures Releasing | false | false |
| 16 | 13 | The Crazies | $15,299 | -29.8% | 34 | - | $449 | $49,397 | 2 | United International Pictures | false | false |
| 17 | 5 | Piranha 3D | $10,642 | -79.8% | 9 | -32 | $1,182 | $333,751 | 4 | Ster-Kinekor Pictures | false | false |
| 18 | 15 | Charlie St. Cloud | $9,532 | -49.8% | 22 | -9 | $433 | $268,800 | 5 | United International Pictures | false | false |
| 19 | 8 | Alpha and Omega | $8,437 | -81.1% | 15 | -35 | $562 | $368,645 | 5 | NuMetro Distribution | false | false |
| 20 | 17 | Why Did I Get Married Too? | $5,898 | -39.2% | 10 | -5 | $589 | $534,147 | 8 | Ster-Kinekor Pictures | false | false |
| 21 | 19 | The Kids Are All Right | $4,807 | -16.1% | 3 | - | $1,602 | $13,863 | 2 | United International Pictures | false | false |
| 22 | 20 | Eyes Wide Open | $4,155 | -17.1% | 2 | - | $2,077 | $11,916 | 2 | United International Pictures | false | false |
| 23 | 22 | The Last Airbender | $2,925 | -5% | 7 | -2 | $417 | $1,328,262 | 11 | United International Pictures | false | false |
