| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Deathly Hallows: Part 1 | $15,094,759 | - | 610 | - | $24,745 | $15,094,759 | 1 | Warner Bros. | true | false |
| 2 | 1 | Jackass 3D | $953,643 | -49.8% | 167 | -31 | $5,710 | $8,122,571 | 3 | Paramount Pictures International | false | false |
| 3 | 2 | The Social Network | $819,388 | -43.3% | 260 | -31 | $3,151 | $9,355,107 | 4 | Sony Pictures Releasing | false | false |
| 4 | 4 | RED | $693,013 | -34.9% | 229 | -15 | $3,026 | $6,566,100 | 4 | Icon Film Distribution | false | false |
| 5 | 3 | Skyline | $441,726 | -64.3% | 183 | +2 | $2,413 | $2,056,342 | 2 | Hopscotch Films | false | false |
| 6 | 5 | Life as We Know It | $334,663 | -45.4% | 184 | -58 | $1,818 | $6,783,850 | 5 | Warner Bros. | false | false |
| 7 | 6 | Wild Target | $331,946 | -40% | 215 | -43 | $1,543 | $1,145,450 | 2 | Icon Film Distribution | false | false |
| 8 | 7 | The American | $238,549 | -36% | 57 | - | $4,185 | $732,714 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Paranormal Activity 2 | $152,260 | -57.7% | 118 | -69 | $1,290 | $6,696,522 | 5 | Paramount Pictures International | false | false |
| 10 | 9 | The Town | $150,405 | -56.2% | 93 | -90 | $1,617 | $7,199,294 | 6 | Warner Bros. | false | false |
| 11 | 10 | Eat Pray Love | $104,212 | -58.9% | 88 | -101 | $1,184 | $11,678,402 | 7 | Sony Pictures Releasing | false | false |
| 12 | 11 | Saw 3D | $94,752 | -61.1% | 71 | -69 | $1,334 | $2,424,417 | 4 | Hoyts Distribution | false | false |
| 13 | 12 | Made in Dagenham | $93,709 | -38.3% | 65 | -19 | $1,441 | $1,074,094 | 4 | Paramount Pictures International | false | false |
| 14 | 13 | Machete | $86,741 | -41.6% | 47 | -3 | $1,845 | $304,337 | 2 | Sony Pictures Releasing | false | false |
| 15 | - | Guzaarish | $80,353 | - | 15 | - | $5,356 | $80,353 | 1 | Mind Blowing Films | true | false |
| 16 | 15 | Winter's Bone | $68,438 | -14.2% | 12 | - | $5,703 | $217,078 | 2 | Curious Films | false | false |
| 17 | - | Agora | $52,530 | - | 9 | - | $5,836 | $52,802 | 1 | Paramount Pictures International | true | false |
| 18 | 16 | The Girl Who Played with Fire | $40,847 | -39.6% | 44 | -17 | $928 | $2,949,123 | 9 | Rialto Distribution | false | false |
| 19 | 17 | Despicable Me | $29,217 | -55.3% | 56 | -23 | $521 | $21,817,532 | 12 | Universal Pictures International (UPI) | false | false |
| 20 | - | Diary of a Wimpy Kid | $21,416 | - | 48 | - | $446 | $5,261,222 | 9 | 20th Century Fox International | false | false |
| 21 | - | GasLand | $18,582 | - | 8 | - | $2,322 | $18,582 | 1 | Palace Films | true | false |
| 22 | - | Copacabana Palace 2010 Re-release | $5,082 | - | 6 | - | $847 | $5,082 | - | Jump Street Films | - | false |
