| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Paranormal Activity 2 | $178,125 | -24.7% | 41 | -4 | $4,344 | $531,446 | 2 | United International Pictures | false | false |
| 2 | 2 | Saw 3D | $90,298 | -24.6% | 53 | +12 | $1,703 | $603,197 | 3 | N/A | false | false |
| 3 | 3 | Due Date | $62,272 | -21.6% | 33 | -3 | $1,887 | $167,030 | 2 | Warner Bros. | false | false |
| 4 | 4 | Legend of the Guardians: The Owls of Ga'Hoole | $55,553 | -14.3% | 44 | +3 | $1,262 | $1,202,829 | 6 | Warner Bros. | false | false |
| 5 | 6 | Qué pena tu vida | $37,209 | -25.7% | 30 | -1 | $1,240 | $401,043 | 4 | N/A | false | false |
| 6 | 7 | The Social Network | $33,938 | -26.9% | 24 | -1 | $1,414 | $213,361 | 3 | Sony Pictures Releasing | false | false |
| 7 | 5 | RED | $31,850 | -37.2% | 25 | -2 | $1,274 | $97,727 | 2 | N/A | false | false |
| 8 | 8 | Eat Pray Love | $26,478 | -22.4% | 16 | - | $1,654 | $366,131 | 5 | Sony Pictures Releasing | false | false |
| 9 | 9 | Life as We Know It | $25,995 | +2.2% | 15 | -1 | $1,733 | $194,724 | 4 | Warner Bros. | false | false |
| 10 | 11 | The Town | $19,618 | -18.5% | 21 | +2 | $934 | $133,351 | 3 | Warner Bros. | false | false |
| 11 | 10 | Step Up 3D | $18,793 | -24.3% | 23 | +1 | $817 | $52,000 | 2 | Walt Disney Pictures | false | false |
| 12 | - | The Girl Who Played with Fire | $17,006 | - | 10 | - | $1,700 | $17,006 | 1 | Andes Films | true | false |
| 13 | 12 | Vampires Suck | $13,985 | -39.6% | 18 | -5 | $776 | $323,580 | 5 | 20th Century Fox International | false | false |
| 14 | - | Hot Tub Time Machine | $12,577 | - | 12 | - | $1,048 | $12,577 | 1 | N/A | true | false |
| 15 | 16 | Nanny McPhee Returns | $5,183 | +16.3% | 5 | -1 | $1,036 | $252,607 | 9 | United International Pictures | false | false |
| 16 | 20 | It's Alive | $5,158 | +128.8% | 10 | +3 | $515 | $93,444 | 6 | N/A | false | false |
| 17 | 14 | Inception | $5,096 | -27.1% | 3 | -1 | $1,698 | $2,559,247 | 14 | Warner Bros. | false | false |
| 18 | 13 | Oceans | $4,380 | -45.1% | 8 | -2 | $547 | $38,562 | 3 | N/A | false | false |
| 19 | 17 | Resident Evil: Afterlife | $3,569 | -14.6% | 3 | -2 | $1,189 | $1,343,399 | 9 | Sony Pictures Releasing | false | false |
| 20 | 23 | Despicable Me | $2,032 | +45.9% | 4 | - | $508 | $1,425,354 | 16 | United International Pictures | false | false |
| 21 | 18 | Vincere | $1,896 | -54.2% | 2 | - | $948 | $34,106 | 4 | N/A | false | false |
| 22 | 19 | Salt | $1,322 | -55.3% | 3 | -3 | $440 | $292,996 | 6 | Sony Pictures Releasing | false | false |
| 23 | 27 | Hachi: A Dog's Tale | $885 | +219.5% | 2 | - | $442 | $287,570 | 9 | N/A | false | false |
| 24 | 25 | The Fourth Kind | $752 | -2.3% | 1 | - | $752 | $177,219 | 12 | Transeuropa | false | false |
| 25 | 24 | Tinker Bell and the Great Fairy Rescue | $546 | -59.1% | 3 | - | $182 | $307,751 | 11 | Walt Disney Pictures | false | false |
| 26 | 21 | Grown Ups | $293 | -85.6% | 2 | -1 | $146 | $611,487 | 10 | Sony Pictures Releasing | false | false |
