| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Saw 3D | $5,776,028 | - | 382 | - | $15,120 | $5,776,028 | 1 | Lionsgate | true | false |
| 2 | 2 | Despicable Me | $4,141,113 | +2% | 532 | -17 | $7,784 | $24,177,379 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | 1 | Paranormal Activity 2 | $2,960,687 | -49.9% | 393 | +4 | $7,533 | $13,314,404 | 2 | Paramount Pictures International | false | false |
| 4 | 3 | RED | $1,900,180 | -27.1% | 413 | +11 | $4,600 | $6,964,700 | 2 | Entertainment One | false | false |
| 5 | 4 | The Social Network | $1,717,384 | -28.8% | 415 | +16 | $4,138 | $12,623,810 | 3 | Sony Pictures Releasing | false | false |
| 6 | - | Burke and Hare | $1,512,794 | - | 390 | - | $3,878 | $1,512,794 | 1 | Entertainment Film Distributors | true | false |
| 7 | 5 | Legend of the Guardians: The Owls of Ga'Hoole | $806,942 | -30.2% | 482 | +10 | $1,674 | $3,503,005 | 2 | Warner Bros. | false | false |
| 8 | 6 | Alpha and Omega | $736,125 | -27.1% | 407 | +16 | $1,808 | $3,220,413 | 2 | Lionsgate | false | false |
| 9 | - | The Kids Are All Right | $660,955 | - | 203 | - | $3,255 | $660,955 | 1 | Universal Pictures International (UPI) | true | false |
| 10 | 7 | Vampires Suck | $503,644 | -39.4% | 347 | -11 | $1,451 | $4,798,312 | 3 | 20th Century Fox International | false | false |
| 11 | 8 | Easy A | $239,128 | -45.2% | 203 | - | $1,177 | $1,241,489 | 2 | Sony Pictures Releasing | false | false |
| 12 | 10 | Wall Street: Money Never Sleeps | $200,282 | -50.7% | 145 | -80 | $1,381 | $6,392,472 | 4 | 20th Century Fox International | false | false |
| 13 | 9 | Life as We Know It | $199,525 | -51.7% | 185 | -124 | $1,078 | $5,281,554 | 4 | Warner Bros. | false | false |
| 14 | 11 | Africa United | $168,706 | -39.5% | 191 | -36 | $883 | $875,298 | 2 | Warner Bros. | false | false |
| 15 | 12 | Made in Dagenham | $150,992 | -38.6% | 142 | -43 | $1,063 | $5,306,946 | 5 | Paramount Pictures International | false | false |
