| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Red | $37,982 | - | 9 | - | $4,220 | $37,982 | 1 | N/A | true | false |
| 2 | 1 | The Town | $27,566 | -47.6% | 10 | - | $2,756 | $87,204 | 2 | Warner Bros. | false | false |
| 3 | 3 | Eat Pray Love | $22,244 | -27.9% | 6 | - | $3,707 | $208,039 | 5 | Sony Pictures Releasing | false | false |
| 4 | 2 | Resident Evil: Afterlife | $21,780 | -35.7% | 10 | - | $2,178 | $124,469 | 3 | United Motion Pictures | false | false |
| 5 | - | Devil | $18,657 | - | 9 | - | $2,073 | $18,657 | 1 | United International Pictures | true | false |
| 6 | 4 | The Social Network | $17,997 | -26.6% | 5 | - | $3,599 | $46,394 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | Step Up 3D | $9,463 | -22% | 2 | -1 | $4,731 | $310,678 | 7 | N/A | false | false |
| 8 | 6 | Legend of the Guardians: The Owls of Ga'Hoole | $7,932 | -32.8% | 7 | - | $1,133 | $21,432 | 2 | Warner Bros. | false | false |
| 9 | 9 | Charlie St. Cloud | $6,737 | -3.9% | 6 | - | $1,122 | $30,394 | 3 | United International Pictures | false | false |
| 10 | 8 | Piranha 3D | $5,506 | -38.2% | 2 | - | $2,753 | $183,201 | 5 | N/A | false | false |
| 11 | 7 | Inception | $5,334 | -43.4% | 2 | -1 | $2,667 | $860,632 | 17 | Warner Bros. | false | false |
| 12 | - | Takers 2010 Re-release | $4,506 | - | 2 | - | $2,253 | $4,506 | 1 | Sony Pictures Releasing | true | false |
| 13 | 10 | The Collector | $3,499 | -43.6% | 2 | -1 | $1,749 | $48,196 | 4 | N/A | false | false |
| 14 | 11 | Dinner for Schmucks | $3,169 | -40.5% | 7 | - | $452 | $44,871 | 4 | United International Pictures | false | false |
| 15 | - | Furry Vengeance | $1,058 | - | 2 | - | $529 | $11,640 | 4 | N/A | false | false |
| 16 | 12 | Despicable Me | $934 | -79.5% | 2 | -3 | $467 | $145,041 | 8 | United International Pictures | false | false |
| 17 | 14 | The American | $699 | -76.5% | 2 | -1 | $349 | $37,381 | 4 | N/A | false | false |
| 18 | 15 | Splice 2010 Re-release | $429 | -71.9% | 4 | -1 | $107 | $35,241 | 7 | N/A | false | false |
| 19 | - | The Twilight Saga: Eclipse | $187 | - | 1 | - | $187 | $440,409 | 18 | United Motion Pictures | false | false |
| 20 | 17 | Predators | $98 | -17.6% | 1 | - | $98 | $59,082 | 11 | 20th Century Fox International | false | false |
| 21 | 18 | The Sorcerer's Apprentice | $49 | -54.6% | 1 | - | $49 | $213,654 | 10 | Walt Disney Pictures | false | false |
| 22 | 20 | The Losers | $35 | -25.5% | 1 | - | $35 | $29,075 | 10 | Warner Bros. | false | false |
| 23 | 13 | You Again | $21 | -99.4% | 1 | -2 | $21 | $10,332 | 3 | Walt Disney Pictures | false | false |
| 24 | 21 | The Last Airbender | $17 | -37% | 1 | - | $17 | $192,167 | 16 | United International Pictures | false | false |
