| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Megamind | $751,355 | - | 96 | - | $7,826 | $751,355 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | 13 | $100,818 | -45% | 50 | - | $2,016 | $344,298 | 2 | N/A | false | false |
| 3 | 2 | The Social Network | $92,931 | -33.4% | 46 | -1 | $2,020 | $293,592 | 2 | Sony Pictures Releasing | false | false |
| 4 | 5 | Legend of the Guardians: The Owls of Ga'Hoole | $55,007 | -26.7% | 46 | -17 | $1,195 | $873,033 | 5 | Warner Bros. | false | false |
| 5 | 4 | RED | $54,353 | -41.3% | 24 | -1 | $2,264 | $344,815 | 3 | N/A | false | false |
| 6 | - | Close Enemy 2010 Re-release | $40,366 | - | 23 | - | $1,755 | $40,366 | 1 | 20th Century Fox International | true | false |
| 7 | 6 | Eat Pray Love | $26,435 | -57.3% | 37 | -7 | $714 | $683,476 | 4 | Sony Pictures Releasing | false | false |
| 8 | 9 | The Justice of Wolves | $24,343 | -33.8% | 34 | - | $715 | $71,425 | 2 | - | false | false |
| 9 | 7 | My Soul to Take | $19,074 | -67.9% | 17 | +2 | $1,122 | $101,171 | 2 | N/A | false | false |
| 10 | 8 | Winx Club 3D: Magical Adventure | $18,976 | -53.3% | 17 | -12 | $1,116 | $88,942 | 2 | N/A | false | false |
| 11 | 3 | Life as We Know It | $18,758 | -81.6% | 31 | -17 | $605 | $428,472 | 3 | Warner Bros. | false | false |
| 12 | 12 | Wall Street: Money Never Sleeps | $5,706 | -35.2% | 23 | -7 | $248 | $267,927 | 5 | 20th Century Fox International | false | false |
| 13 | 14 | Avatar | $4,755 | -16.6% | 5 | +1 | $951 | $8,445,755 | 46 | 20th Century Fox International | false | false |
| 14 | 11 | The Other Guys | $4,028 | -72.5% | 27 | -7 | $149 | $365,187 | 5 | Sony Pictures Releasing | false | false |
| 15 | 15 | Inception | $1,629 | -20.5% | 1 | -1 | $1,629 | $1,493,404 | 15 | Warner Bros. | false | false |
| 16 | 13 | Resident Evil: Afterlife | $1,570 | -78.3% | 20 | -7 | $78 | $1,734,040 | 7 | Sony Pictures Releasing | false | false |
| 17 | 18 | Despicable Me | $951 | +109.5% | 2 | - | $475 | $1,097,471 | 16 | Universal Pictures International (UPI) | false | false |
| 18 | 16 | Going the Distance | $719 | -59.6% | 1 | -2 | $719 | $323,798 | 8 | Warner Bros. | false | false |
| 19 | 20 | Tinker Bell and the Great Fairy Rescue | $30 | -61% | 1 | -1 | $30 | $82,973 | 12 | Walt Disney Pictures | false | false |
