| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Men Vs Women | $4,222,767 | - | 572 | - | $7,382 | $5,053,304 | 1 | 01 Distribution | true | false |
| 2 | 1 | Welcome to the South | $2,610,534 | -32.9% | 463 | -51 | $5,638 | $32,942,919 | 5 | Medusa Distribuzione | false | false |
| 3 | 2 | Despicable Me | $1,794,535 | -50.2% | 417 | -123 | $4,303 | $12,458,016 | 3 | United International Pictures | false | false |
| 4 | - | Salt | $1,048,329 | - | 297 | - | $3,529 | $1,048,329 | 1 | Sony Pictures Releasing | true | false |
| 5 | - | Winx Club 3D: Magical Adventure | $935,111 | - | 360 | - | $2,597 | $935,111 | 1 | Medusa Distribuzione | true | false |
| 6 | 3 | Wall Street: Money Never Sleeps | $800,912 | -48.1% | - | - | - | $2,873,226 | 2 | 20th Century Fox International | false | false |
| 7 | 4 | Paranormal Activity 2 | $794,343 | -48.4% | 230 | -20 | $3,453 | $2,862,761 | 2 | United International Pictures | false | false |
| 8 | - | Legend of the Guardians: The Owls of Ga'Hoole | $559,946 | - | 298 | - | $1,879 | $559,946 | 1 | Warner Bros. | true | false |
| 9 | 6 | Unlikely Revolutionaries | $369,201 | -53.1% | 250 | -15 | $1,476 | $1,439,895 | 2 | Warner Bros. | false | false |
| 10 | 5 | Step Up 3D | $303,738 | -70.4% | 100 | -109 | $3,037 | $9,120,177 | 4 | Eagle Pictures | false | false |
| 11 | 12 | Of Gods and Men | $235,425 | +24.8% | 64 | +11 | $3,678 | $548,713 | 2 | Lucky Red | false | false |
| 12 | 9 | Inception | $227,046 | -55.3% | 64 | -72 | $3,547 | $14,473,127 | 6 | Warner Bros. | false | false |
| 13 | 7 | Fair Game | $208,805 | -65.4% | 132 | -67 | $1,581 | $1,103,907 | 2 | Eagle Pictures | false | false |
| 14 | 10 | Buried | $104,430 | -73.6% | 54 | -82 | $1,933 | $2,033,268 | 3 | N/A | false | false |
| 15 | 8 | The Extraordinary Adventures of Adèle Blanc-Sec | $95,922 | -82.4% | 72 | -148 | $1,332 | $2,122,659 | 3 | Medusa Distribuzione | false | false |
| 16 | 11 | The Town | $74,486 | -76.3% | 30 | -101 | $2,482 | $3,228,229 | 4 | Warner Bros. | false | false |
| 17 | - | Mammuth | $73,515 | - | 22 | - | $3,341 | $73,515 | 1 | Fandango | true | false |
| 18 | 17 | Passione | $65,406 | -11.1% | - | - | - | $181,677 | 2 | 01 Distribution | false | false |
| 19 | - | Animal Kingdom | $61,441 | - | 36 | - | $1,706 | $61,441 | 1 | Mikado Film | true | false |
| 20 | 15 | The City of Your Final Destination | $58,649 | -44.5% | 26 | -16 | $2,255 | $721,378 | 4 | Teodora Film | false | false |
| 21 | 14 | Gorbaciof | $50,774 | -60.9% | 21 | -84 | $2,417 | $731,596 | 3 | Lucky Red | false | false |
| 22 | - | The Illusionist | $46,314 | - | 19 | - | $2,437 | $46,314 | 1 | Sacher Distribuzione | true | false |
| 23 | 16 | A Second Childhood | $32,450 | -61.5% | 16 | -27 | $2,028 | $1,293,856 | 4 | 01 Distribution | false | false |
| 24 | 18 | La passione di Laura | $28,775 | -52.1% | 20 | - | $1,438 | $3,256,130 | 6 | 01 Distribution | false | false |
| 25 | 22 | Seraphine | $17,240 | +17% | 11 | -1 | $1,567 | $39,946 | 2 | One Movie | false | false |
| 26 | 20 | The Black Sheep | $16,604 | -48.2% | 8 | -9 | $2,075 | $729,552 | 5 | BIM Distribuzione | false | false |
| 27 | 19 | The Last Airbender | $7,497 | -81.6% | 9 | -9 | $833 | $7,821,944 | 6 | United International Pictures | false | false |
| 28 | 24 | The Solitude of Prime Numbers | $4,956 | -54.8% | 4 | -4 | $1,239 | $4,657,121 | 8 | Medusa Distribuzione | false | false |
| 29 | 23 | Eat Pray Love | $2,696 | -76.1% | 6 | -17 | $449 | $4,987,027 | 7 | Sony Pictures Releasing | false | false |
