| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Town | $52,570 | - | 10 | - | $5,257 | $52,570 | 1 | Warner Bros. | true | false |
| 2 | 1 | Resident Evil: Afterlife | $33,872 | -39.3% | 10 | - | $3,387 | $98,067 | 2 | - | false | false |
| 3 | 2 | Eat Pray Love | $30,871 | -15.3% | 6 | - | $5,145 | $180,429 | 4 | Sony Pictures Releasing | false | false |
| 4 | - | The Social Network | $24,511 | - | 5 | - | $4,902 | $24,511 | 1 | Sony Pictures Releasing | true | false |
| 5 | 4 | Step Up 3D | $12,126 | -28.8% | 3 | - | $4,042 | $303,001 | 6 | N/A | false | false |
| 6 | - | Legend of the Guardians: The Owls of Ga'Hoole | $11,811 | - | 7 | - | $1,687 | $11,811 | 1 | Warner Bros. | true | false |
| 7 | 9 | Inception | $9,416 | -13.5% | 3 | -1 | $3,138 | $864,645 | 16 | Warner Bros. | false | false |
| 8 | 3 | Piranha 3D | $8,910 | -54.9% | 2 | -2 | $4,455 | $178,511 | 4 | N/A | false | false |
| 9 | 5 | Charlie St. Cloud | $7,007 | -49.9% | 6 | - | $1,167 | $22,785 | 2 | United International Pictures | false | false |
| 10 | 6 | The Collector | $6,208 | -54.6% | 3 | -3 | $2,069 | $44,309 | 3 | N/A | false | false |
| 11 | 7 | Dinner for Schmucks | $5,330 | -57.8% | 7 | -1 | $761 | $41,621 | 3 | United International Pictures | false | false |
| 12 | 11 | Despicable Me | $4,561 | -24.3% | 5 | - | $912 | $145,921 | 7 | United International Pictures | false | false |
| 13 | 12 | You Again | $3,348 | -39.3% | 3 | - | $1,116 | $9,769 | 2 | Walt Disney Pictures | false | false |
| 14 | 8 | The American | $2,969 | -75.8% | 3 | -2 | $989 | $36,609 | 3 | N/A | false | false |
| 15 | 15 | Splice 2010 Re-release | $1,526 | +13.9% | 5 | - | $305 | $35,075 | 6 | N/A | false | false |
| 16 | 10 | Wall Street: Money Never Sleeps | $189 | -97.4% | 1 | -2 | $189 | $78,785 | 5 | 20th Century Fox International | false | false |
| 17 | 19 | Predators | $119 | -23.2% | 1 | - | $119 | $59,692 | 10 | 20th Century Fox International | false | false |
| 18 | 14 | The Sorcerer's Apprentice | $108 | -97.3% | 1 | -2 | $108 | $216,274 | 9 | Walt Disney Pictures | false | false |
| 19 | 18 | Letters to Juliet | $104 | -76.9% | 1 | -2 | $104 | $22,143 | 5 | N/A | false | false |
| 20 | 21 | The Losers | $47 | +20.5% | 1 | - | $47 | $29,381 | 9 | Warner Bros. | false | false |
| 21 | 20 | The Last Airbender | $27 | -55.7% | 1 | - | $27 | $194,555 | 15 | United International Pictures | false | false |
