| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Elite Squad 2: The Enemy Within | $4,364,486 | -18.2% | 666 | -23 | $6,553 | $40,996,467 | 4 | N/A | false | false |
| 2 | 2 | Paranormal Activity 2 | $779,968 | -13.2% | 165 | -3 | $4,727 | $2,136,361 | 2 | Paramount Pictures International | false | false |
| 3 | - | Garfield's Pet Force | $609,773 | - | 192 | - | $3,175 | $609,773 | 1 | PlayArte Pictures | true | false |
| 4 | 3 | Eat Pray Love | $580,763 | -19.7% | 225 | +10 | $2,581 | $8,949,621 | 5 | Sony Pictures Releasing | false | false |
| 5 | - | Extreme Happiness | $409,977 | - | 168 | - | $2,440 | $409,977 | 1 | Paramount Pictures International | true | false |
| 6 | 5 | Life as We Know It | $350,661 | -29.6% | 141 | -14 | $2,486 | $1,636,630 | 3 | Warner Bros. | false | false |
| 7 | 6 | Grown Ups | $298,471 | -22.1% | 159 | -1 | $1,877 | $6,874,123 | 6 | Sony Pictures Releasing | false | false |
| 8 | - | The Town | $277,495 | - | 51 | - | $5,441 | $277,495 | 1 | Warner Bros. | true | false |
| 9 | 4 | Legend of the Guardians: The Owls of Ga'Hoole | $261,415 | -60.4% | 133 | -110 | $1,965 | $6,782,596 | 4 | Warner Bros. | false | false |
| 10 | - | Federal | $169,573 | - | 63 | - | $2,691 | $169,573 | 1 | Europa Filmes | true | false |
| 11 | 7 | Piranha 3D | $123,969 | -66.3% | 140 | -53 | $885 | $769,785 | 2 | N/A | false | false |
| 12 | - | The Extraordinary Adventures of Adèle Blanc-Sec | $81,892 | - | 37 | - | $2,213 | $81,892 | 1 | N/A | true | false |
| 13 | 9 | Astral City: A Spiritual Journey | $66,844 | -49.7% | 109 | -71 | $613 | $21,122,135 | 9 | 20th Century Fox International | false | false |
| 14 | 10 | Solitary Man | $65,109 | -49.8% | 26 | -6 | $2,504 | $242,364 | 2 | N/A | false | false |
| 15 | 12 | Avatar 2010 Special Edition | $45,115 | -16.6% | 14 | -28 | $3,222 | $452,157 | 3 | 20th Century Fox International | false | false |
| 16 | 8 | Stone | $41,195 | -69.9% | 27 | -14 | $1,525 | $236,910 | 2 | N/A | false | false |
| 17 | 19 | The Switch | $37,044 | +112.1% | 34 | +9 | $1,089 | $1,969,163 | 7 | N/A | false | false |
| 18 | 11 | Vampires Suck | $31,182 | -55.2% | 64 | -24 | $487 | $2,152,447 | 5 | 20th Century Fox International | false | false |
| 19 | 13 | Resident Evil: Afterlife | $19,577 | -62.1% | 67 | -31 | $292 | $9,450,561 | 7 | Sony Pictures Releasing | false | false |
| 20 | 16 | Nanny McPhee Returns | $19,404 | -11% | 41 | +13 | $473 | $800,275 | 7 | Universal Pictures International (UPI) | false | false |
| 21 | 21 | Me and My Umbrella | $14,674 | +0.9% | 47 | +8 | $312 | $339,342 | 4 | 20th Century Fox International | false | false |
| 22 | 15 | So Hard to Forget | $12,841 | -45.4% | 12 | -10 | $1,070 | $123,027 | 3 | Europa Filmes | false | false |
| 23 | 20 | Despicable Me | $9,917 | -33.9% | 38 | -25 | $260 | $13,714,454 | 13 | Universal Pictures International (UPI) | false | false |
| 24 | 22 | Cats & Dogs: The Revenge of Kitty Galore | $9,282 | -18% | 37 | +3 | $250 | $3,674,186 | 9 | Warner Bros. | false | false |
| 25 | 14 | Tell Tale | $6,115 | -84.1% | 10 | -35 | $611 | $71,197 | 2 | PlayArte Pictures | false | false |
| 26 | 27 | Toy Story 3 | $5,328 | +65.6% | 18 | -2 | $296 | $25,001,897 | 20 | Walt Disney Pictures | false | false |
| 27 | 25 | The Karate Kid | $5,268 | -19.4% | 14 | -9 | $376 | $10,136,702 | 10 | Sony Pictures Releasing | false | false |
| 28 | - | Please Give | $3,704 | - | 5 | - | $740 | $5,735 | 1 | Sony Pictures Releasing | true | false |
| 29 | 26 | The Sorcerer's Apprentice | $1,751 | -58.5% | 9 | -4 | $194 | $5,011,104 | 12 | Walt Disney Pictures | false | false |
| 30 | 30 | Solomon Kane | $1,729 | +60.2% | 5 | - | $345 | $639,430 | 8 | Paris Filmes | false | false |
| 31 | 31 | A Prophet | $1,049 | +21.6% | 4 | +2 | $262 | $165,498 | 20 | Sony Pictures Releasing | false | false |
| 32 | 29 | The Well Beloved One | $792 | -43.5% | 3 | -4 | $264 | $4,956,524 | 15 | Walt Disney Pictures | false | false |
| 33 | 34 | The Imaginarium of Doctor Parnassus | $696 | +24.7% | 4 | +2 | $174 | $164,712 | 26 | Sony Pictures Releasing | false | false |
| 34 | 32 | 5x Favela: Now by Ourselves | $581 | -8.4% | 4 | - | $145 | $766,811 | 10 | Sony Pictures Releasing | false | false |
