| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 13 | $183,172 | - | 50 | - | $3,663 | $183,172 | 1 | N/A | true | false |
| 2 | - | The Social Network | $139,617 | - | 47 | - | $2,970 | $145,313 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | Life as We Know It | $102,172 | -37.4% | 48 | -1 | $2,128 | $323,466 | 2 | Warner Bros. | false | false |
| 4 | 4 | RED | $92,541 | -23.9% | 25 | - | $3,701 | $257,442 | 2 | N/A | false | false |
| 5 | 3 | Legend of the Guardians: The Owls of Ga'Hoole | $75,049 | -40.3% | 63 | -9 | $1,191 | $809,947 | 4 | Warner Bros. | false | false |
| 6 | 2 | Eat Pray Love | $61,900 | -59.2% | 44 | -2 | $1,406 | $632,840 | 3 | Sony Pictures Releasing | false | false |
| 7 | - | My Soul to Take | $59,373 | - | 15 | - | $3,958 | $59,373 | 1 | N/A | true | false |
| 8 | - | Winx Club 3D: Magical Adventure | $40,607 | - | 29 | - | $1,400 | $40,607 | 1 | N/A | true | false |
| 9 | - | The Justice of Wolves | $36,788 | - | 34 | - | $1,082 | $36,788 | 1 | JRC Film | true | false |
| 10 | 5 | Dark World | $17,982 | -69.1% | 33 | -20 | $544 | $281,571 | 3 | N/A | false | false |
| 11 | 7 | The Other Guys | $14,632 | -44.8% | 34 | -8 | $430 | $354,334 | 4 | Sony Pictures Releasing | false | false |
| 12 | 9 | Wall Street: Money Never Sleeps | $8,802 | -51.5% | 30 | -3 | $293 | $258,241 | 4 | 20th Century Fox International | false | false |
| 13 | 8 | Resident Evil: Afterlife | $7,247 | -61.9% | 27 | -27 | $268 | $1,730,090 | 6 | Sony Pictures Releasing | false | false |
| 14 | 11 | Avatar | $5,704 | +3.6% | 4 | -1 | $1,426 | $8,438,123 | 45 | 20th Century Fox International | false | false |
| 15 | 12 | Inception | $2,050 | -43% | 2 | -2 | $1,025 | $1,491,044 | 14 | Warner Bros. | false | false |
| 16 | 13 | Going the Distance | $1,780 | -42.7% | 3 | -5 | $593 | $322,218 | 7 | Warner Bros. | false | false |
| 17 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $508 | +512% | 2 | +1 | $254 | $515,498 | 13 | Warner Bros. | false | false |
| 18 | 15 | Despicable Me | $454 | +66.9% | 2 | -1 | $227 | $1,096,419 | 15 | Universal Pictures International (UPI) | false | false |
| 19 | 14 | Toy Story 3 | $177 | -53.5% | 1 | - | $177 | $665,712 | 18 | Walt Disney Pictures | false | false |
| 20 | 16 | Tinker Bell and the Great Fairy Rescue | $77 | -18.9% | 2 | - | $38 | $82,885 | 11 | Walt Disney Pictures | false | false |
| 21 | - | Shrek Forever After | $68 | - | 1 | - | $68 | $4,007,651 | 23 | Paramount Pictures International | false | false |
