| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Resident Evil: Afterlife | $55,794 | - | 10 | - | $5,579 | $55,794 | 1 | United Motion Pictures | true | false |
| 2 | 2 | Eat Pray Love | $36,433 | -1.9% | 6 | +2 | $6,072 | $142,692 | 3 | Sony Pictures Releasing | false | false |
| 3 | 1 | Piranha 3D | $19,739 | -52.7% | 4 | -4 | $4,934 | $166,879 | 3 | N/A | false | false |
| 4 | 3 | Step Up 3D | $17,037 | -48.9% | 3 | -2 | $5,679 | $287,988 | 5 | N/A | false | false |
| 5 | - | Charlie St. Cloud | $13,978 | - | 6 | - | $2,329 | $13,978 | 1 | United International Pictures | true | false |
| 6 | 5 | The Collector | $13,685 | -23% | 6 | - | $2,280 | $35,488 | 2 | N/A | false | false |
| 7 | 4 | Dinner for Schmucks | $12,634 | -42.1% | 8 | - | $1,579 | $35,637 | 2 | United International Pictures | false | false |
| 8 | 6 | The American | $12,261 | -26.1% | 5 | - | $2,452 | $31,530 | 2 | N/A | false | false |
| 9 | 8 | Inception | $10,880 | -11.3% | 4 | +1 | $2,720 | $853,372 | 15 | Warner Bros. | false | false |
| 10 | 9 | Wall Street: Money Never Sleeps | $7,167 | -8.8% | 3 | - | $2,389 | $77,432 | 4 | 20th Century Fox International | false | false |
| 11 | 7 | Despicable Me | $6,026 | -61.4% | 5 | -3 | $1,205 | $141,360 | 6 | United International Pictures | false | false |
| 12 | - | You Again | $5,515 | - | 3 | - | $1,838 | $5,515 | 1 | Walt Disney Pictures | true | false |
| 13 | 11 | Furry Vengeance | $4,404 | -13.2% | 2 | - | $2,202 | $10,088 | 2 | N/A | false | false |
| 14 | 10 | The Sorcerer's Apprentice | $4,055 | -44.8% | 3 | -2 | $1,351 | $215,634 | 8 | Walt Disney Pictures | false | false |
| 15 | 13 | Splice 2010 Re-release | $1,340 | -61.4% | 5 | -3 | $268 | $33,152 | 5 | N/A | false | false |
| 16 | - | Toy Story 3 | $1,192 | - | 1 | - | $1,192 | $435,046 | 19 | Walt Disney Pictures | false | false |
| 17 | 16 | Going the Distance | $731 | -35.4% | 1 | - | $731 | $37,718 | 5 | Warner Bros. | false | false |
| 18 | 15 | Letters to Juliet | $451 | -70.3% | 3 | - | $150 | $22,010 | 4 | N/A | false | false |
| 19 | 17 | Predators | $155 | -42.2% | 1 | - | $155 | $59,525 | 9 | 20th Century Fox International | false | false |
| 20 | 19 | The Last Airbender | $61 | - | 1 | - | $61 | $194,523 | 14 | United International Pictures | false | false |
| 21 | 20 | The Losers | $39 | -13.3% | 1 | - | $39 | $29,316 | 8 | Warner Bros. | false | false |
