| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Elite Squad 2: The Enemy Within | $5,337,452 | -26.3% | 689 | -50 | $7,746 | $33,345,233 | 3 | N/A | false | false |
| 2 | - | Paranormal Activity 2 | $898,780 | - | 168 | - | $5,349 | $898,780 | 1 | Paramount Pictures International | true | false |
| 3 | 3 | Eat Pray Love | $723,248 | -33.8% | 215 | -22 | $3,363 | $8,035,647 | 4 | Sony Pictures Releasing | false | false |
| 4 | 2 | Legend of the Guardians: The Owls of Ga'Hoole | $659,969 | -47.1% | 243 | -36 | $2,715 | $6,257,318 | 3 | Warner Bros. | false | false |
| 5 | 5 | Life as We Know It | $498,315 | +25.4% | 155 | +78 | $3,214 | $1,055,279 | 2 | Warner Bros. | false | false |
| 6 | 4 | Grown Ups | $382,927 | -40.9% | 160 | -15 | $2,393 | $6,415,002 | 5 | Sony Pictures Releasing | false | false |
| 7 | - | Piranha 3D | $367,918 | - | 193 | - | $1,906 | $367,918 | 1 | N/A | true | false |
| 8 | - | Stone | $136,714 | - | 41 | - | $3,334 | $136,714 | 1 | N/A | true | false |
| 9 | 6 | Astral City: A Spiritual Journey | $132,970 | -59.5% | 180 | -111 | $738 | $20,930,390 | 8 | 20th Century Fox International | false | false |
| 10 | - | Solitary Man | $129,732 | - | 32 | - | $4,054 | $129,732 | 1 | N/A | true | false |
| 11 | 7 | Vampires Suck | $69,595 | -68.7% | 88 | -37 | $790 | $2,077,636 | 4 | 20th Century Fox International | false | false |
| 12 | 9 | Avatar 2010 Special Edition | $54,094 | -54.8% | 42 | -37 | $1,287 | $387,344 | 2 | 20th Century Fox International | false | false |
| 13 | 8 | Resident Evil: Afterlife | $51,625 | -65.1% | 98 | -40 | $526 | $9,408,757 | 6 | Sony Pictures Releasing | false | false |
| 14 | - | Tell Tale | $38,454 | - | 45 | - | $854 | $38,454 | 1 | PlayArte Pictures | true | false |
| 15 | 14 | So Hard to Forget | $23,510 | -44.2% | 22 | - | $1,068 | $100,420 | 2 | Europa Filmes | false | false |
| 16 | 15 | Nanny McPhee Returns | $21,795 | -44.5% | 28 | -11 | $778 | $771,648 | 6 | Universal Pictures International (UPI) | false | false |
| 17 | 16 | Brother and Sister | $19,492 | -43.6% | 10 | -2 | $1,949 | $160,287 | 3 | N/A | false | false |
| 18 | 10 | Wall Street: Money Never Sleeps | $19,284 | -83.1% | 18 | -41 | $1,071 | $2,416,343 | 5 | 20th Century Fox International | false | false |
| 19 | 12 | The Switch | $17,464 | -72.5% | 25 | -18 | $698 | $1,918,633 | 6 | N/A | false | false |
| 20 | 17 | Despicable Me | $15,005 | -51.1% | 63 | -45 | $238 | $13,696,896 | 12 | Universal Pictures International (UPI) | false | false |
| 21 | 13 | Me and My Umbrella | $14,541 | -68.9% | 39 | -37 | $372 | $318,558 | 3 | 20th Century Fox International | false | false |
| 22 | 21 | Cats & Dogs: The Revenge of Kitty Galore | $11,325 | -4% | 34 | - | $333 | $3,659,003 | 8 | Warner Bros. | false | false |
| 23 | 11 | The Last Exorcism | $9,155 | -86% | 23 | -50 | $398 | $2,032,160 | 5 | PlayArte Pictures | false | false |
| 24 | 19 | The Last Airbender | $8,267 | -62.2% | 46 | -24 | $179 | $9,653,005 | 10 | Paramount Pictures International | false | false |
| 25 | 18 | The Karate Kid | $6,533 | -75.1% | 23 | -29 | $284 | $10,128,179 | 9 | Sony Pictures Releasing | false | false |
| 26 | 22 | The Sorcerer's Apprentice | $4,215 | -50.5% | 13 | -9 | $324 | $5,007,327 | 11 | Walt Disney Pictures | false | false |
| 27 | 26 | Toy Story 3 | $3,218 | -26.1% | 20 | - | $160 | $24,996,569 | 19 | Walt Disney Pictures | false | false |
| 28 | 20 | Going the Distance | $1,839 | -86.7% | 4 | -10 | $459 | $1,587,217 | 7 | Warner Bros. | false | false |
| 29 | 31 | The Well Beloved One | $1,403 | +33% | 7 | - | $200 | $4,954,584 | 14 | Walt Disney Pictures | false | false |
| 30 | 24 | Solomon Kane | $1,079 | -82.2% | 5 | -7 | $215 | $636,221 | 7 | Paris Filmes | false | false |
| 31 | 32 | A Prophet | $863 | +143.1% | 2 | +1 | $431 | $163,709 | 19 | Sony Pictures Releasing | false | false |
| 32 | 29 | 5x Favela: Now by Ourselves | $634 | -55.4% | 4 | -3 | $158 | $765,802 | 9 | Sony Pictures Releasing | false | false |
| 33 | 33 | The Last Song | $581 | +126.1% | 2 | +1 | $290 | $113,205 | 20 | Walt Disney Pictures | false | false |
| 34 | 35 | The Imaginarium of Doctor Parnassus | $558 | +862.1% | 2 | +1 | $279 | $163,773 | 25 | Sony Pictures Releasing | false | false |
| 35 | - | Alice in Wonderland | $431 | - | 2 | - | $215 | $28,360,362 | 27 | Walt Disney Pictures | false | false |
