| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Life as We Know It | $163,150 | - | 49 | - | $3,329 | $163,900 | 1 | Warner Bros. | true | false |
| 2 | 1 | Eat Pray Love | $151,737 | -46.7% | 46 | +3 | $3,298 | $527,243 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | Legend of the Guardians: The Owls of Ga'Hoole | $125,718 | -37% | 72 | +1 | $1,746 | $709,829 | 3 | Warner Bros. | false | false |
| 4 | - | RED | $121,557 | - | 25 | - | $4,862 | $121,557 | 1 | N/A | true | false |
| 5 | 3 | Dark World | $58,221 | -56.3% | 53 | - | $1,098 | $237,449 | 2 | N/A | false | false |
| 6 | - | Stone | $40,006 | - | 23 | - | $1,739 | $40,006 | 1 | N/A | true | false |
| 7 | 4 | The Other Guys | $26,509 | -68.1% | 42 | -3 | $631 | $330,121 | 3 | Sony Pictures Releasing | false | false |
| 8 | 6 | Resident Evil: Afterlife | $19,043 | -65.7% | 54 | -35 | $352 | $1,692,910 | 5 | Sony Pictures Releasing | false | false |
| 9 | 5 | Wall Street: Money Never Sleeps | $18,135 | -69.8% | 33 | -1 | $549 | $242,707 | 3 | 20th Century Fox International | false | false |
| 10 | 7 | The Edge | $12,671 | -44.4% | 34 | -6 | $372 | $248,816 | 4 | N/A | false | false |
| 11 | 12 | Avatar | $5,508 | +63.8% | 5 | +1 | $1,101 | $8,430,507 | 44 | 20th Century Fox International | false | false |
| 12 | 11 | Inception | $3,599 | -44.5% | 4 | -1 | $899 | $1,487,581 | 13 | Warner Bros. | false | false |
| 13 | 10 | Going the Distance | $3,107 | -53.2% | 8 | -9 | $388 | $319,461 | 6 | Warner Bros. | false | false |
| 14 | 14 | Toy Story 3 | $381 | -40.6% | 1 | - | $381 | $665,531 | 17 | Walt Disney Pictures | false | false |
| 15 | 13 | Despicable Me | $272 | -65.7% | 3 | -2 | $90 | $1,095,859 | 14 | Universal Pictures International (UPI) | false | false |
| 16 | 18 | Tinker Bell and the Great Fairy Rescue | $95 | +187.9% | 2 | +1 | $47 | $82,781 | 10 | Walt Disney Pictures | false | false |
| 17 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $83 | +80.4% | 1 | - | $83 | $514,982 | 12 | Warner Bros. | false | false |
| 18 | 15 | The Karate Kid | $34 | -93.8% | 1 | -5 | $34 | $318,404 | 9 | Sony Pictures Releasing | false | false |
