| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Welcome to the South | $5,528,640 | -11.4% | 556 | -12 | $9,943 | $23,760,115 | 3 | Medusa Distribuzione | false | false |
| 2 | - | Despicable Me | $4,902,039 | - | 544 | - | $9,011 | $4,902,039 | 1 | United International Pictures | true | false |
| 3 | 2 | Step Up 3D | $2,196,071 | -33.7% | 272 | -67 | $8,073 | $7,015,171 | 2 | Eagle Pictures | false | false |
| 4 | 3 | Inception | $1,125,801 | -32.2% | 250 | -151 | $4,503 | $13,176,907 | 4 | Warner Bros. | false | false |
| 5 | - | The Extraordinary Adventures of Adèle Blanc-Sec | $1,102,111 | - | 260 | - | $4,238 | $1,102,111 | 1 | Medusa Distribuzione | true | false |
| 6 | - | Buried | $1,041,443 | - | 166 | - | $6,273 | $1,064,199 | 1 | N/A | true | false |
| 7 | 5 | The Town | $890,316 | -15.8% | 252 | -2 | $3,533 | $2,464,326 | 2 | Warner Bros. | false | false |
| 8 | 4 | Knight and Day 2010 Re-release | $769,463 | -37.7% | 303 | -71 | $2,539 | $2,480,120 | 2 | 20th Century Fox International | false | false |
| 9 | - | Gorbaciof | $368,747 | - | 133 | - | $2,772 | $368,747 | 1 | Lucky Red | true | false |
| 10 | 7 | A Second Childhood | $323,379 | -36.6% | 189 | - | $1,711 | $1,061,906 | 2 | 01 Distribution | false | false |
| 11 | 6 | The Last Airbender | $203,530 | -76.7% | 80 | -164 | $2,544 | $7,843,921 | 4 | United International Pictures | false | false |
| 12 | 11 | The City of Your Final Destination | $191,973 | +9.2% | 58 | +8 | $3,309 | $450,021 | 2 | Teodora Film | false | false |
| 13 | 8 | La passione di Laura | $148,189 | -52.6% | 63 | - | $2,352 | $3,132,949 | 4 | 01 Distribution | false | false |
| 14 | 12 | The Black Sheep | $94,713 | -38.4% | 43 | -23 | $2,202 | $623,319 | 3 | BIM Distribuzione | false | false |
| 15 | - | Uncle Boonmee Who Can Recall His Past Lives | $64,926 | - | - | - | - | $64,926 | 1 | BIM Distribuzione | true | false |
| 16 | 9 | Grown Ups | $41,819 | -81.1% | 13 | -132 | $3,216 | $1,072,960 | 3 | Sony Pictures Releasing | false | false |
| 17 | 10 | Eat Pray Love | $36,970 | -79.1% | 51 | -47 | $724 | $5,316,509 | 5 | Sony Pictures Releasing | false | false |
| 18 | 14 | Sharm el Sheikh - Un'estate indimenticabile | $30,659 | -74.9% | 16 | -46 | $1,916 | $4,427,419 | 5 | Medusa Distribuzione | false | false |
| 19 | 15 | Shrek Forever After | $23,498 | -79.8% | - | - | - | $23,772,304 | 8 | United International Pictures | false | false |
| 20 | 18 | The Solitude of Prime Numbers | $20,021 | -55.9% | 14 | -21 | $1,430 | $4,685,740 | 6 | Medusa Distribuzione | false | false |
| 21 | 20 | Somewhere | $16,100 | -56.2% | 7 | -15 | $2,300 | $2,767,171 | 7 | Medusa Distribuzione | false | false |
| 22 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $10,289 | -82.5% | 11 | -41 | $935 | $1,831,165 | 5 | Warner Bros. | false | false |
| 23 | 13 | Vampires Suck | $9,312 | -93% | 12 | -86 | $776 | $5,997,426 | 5 | 20th Century Fox International | false | false |
| 24 | 19 | Horse | $8,694 | -78.9% | 5 | -31 | $1,738 | $292,786 | 3 | Fandango | false | false |
| 25 | 21 | Toy Story 3 | $8,532 | -35.7% | 11 | -5 | $775 | $18,849,659 | 15 | Walt Disney Pictures | false | false |
| 26 | 25 | The Secret in Their Eyes | $6,065 | +14% | 3 | - | $2,021 | $1,540,198 | 20 | Lucky Red | false | false |
| 27 | - | L'estate d'inverno | $4,853 | - | 4 | - | $1,213 | $4,853 | 1 | N/A | true | false |
| 28 | 26 | 20 Cigarettes | $3,846 | -24.6% | 5 | - | $769 | $281,662 | 6 | Istituto Luce | false | false |
| 29 | 23 | Resident Evil: Afterlife | $3,796 | -50.9% | 4 | -4 | $949 | $5,253,337 | 6 | Sony Pictures Releasing | false | false |
| 30 | 32 | My Son, My Son, What Have Ye Done | $2,262 | -18.8% | 3 | -2 | $754 | $67,394 | 6 | N/A | false | false |
| 31 | 30 | The Karate Kid | $1,753 | -37.7% | 8 | -1 | $219 | $2,569,778 | 7 | Sony Pictures Releasing | false | false |
