| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Legend of the Guardians: The Owls of Ga'Hoole | $368,148 | -18% | 143 | -19 | $2,574 | $1,922,650 | 3 | Warner Bros. | false | false |
| 2 | - | The Town | $131,241 | - | 46 | - | $2,853 | $131,241 | 1 | Warner Bros. | true | false |
| 3 | 2 | Eat Pray Love | $114,937 | -8.5% | 25 | - | $4,597 | $502,269 | 3 | Sony Pictures Releasing | false | false |
| 4 | 3 | Avatar 2010 Special Edition | $88,459 | -27% | 40 | -6 | $2,211 | $299,722 | 2 | 20th Century Fox International | false | false |
| 5 | 5 | Tinker Bell and the Great Fairy Rescue | $83,392 | -15.4% | 39 | -2 | $2,138 | $268,461 | 2 | Walt Disney Pictures | false | false |
| 6 | 4 | Resident Evil: Afterlife | $67,279 | -43.1% | 46 | -22 | $1,462 | $3,055,671 | 6 | Sony Pictures Releasing | false | false |
| 7 | - | The Collector | $61,621 | - | 26 | - | $2,370 | $61,621 | 1 | Venus | true | false |
| 8 | - | Takers 2010 Re-release | $56,282 | - | 30 | - | $1,876 | $56,282 | 1 | Sony Pictures Releasing | true | false |
| 9 | 6 | Wall Street: Money Never Sleeps | $38,731 | -45.2% | 33 | -7 | $1,173 | $421,217 | 4 | 20th Century Fox International | false | false |
| 10 | 7 | Inception | $33,449 | -29% | 16 | -11 | $2,090 | $3,166,789 | 11 | Warner Bros. | false | false |
| 11 | 8 | The Last Airbender | $26,216 | -34.3% | 39 | -16 | $672 | $3,459,802 | 8 | United International Pictures | false | false |
| 12 | 11 | Vampires Suck | $22,032 | +12.7% | 15 | +2 | $1,468 | $221,435 | 7 | 20th Century Fox International | false | false |
| 13 | 12 | Cats & Dogs: The Revenge of Kitty Galore | $19,031 | +3% | 31 | -1 | $613 | $2,115,619 | 10 | Warner Bros. | false | false |
| 14 | 10 | From Paris with Love | $14,291 | -29.6% | 16 | -6 | $893 | $158,240 | 5 | - | false | false |
| 15 | - | Despicable Me | $11,898 | - | 27 | - | $440 | $2,791,795 | - | Universal Pictures International (UPI) | - | false |
| 16 | 15 | Grown Ups | $8,648 | -1.5% | 6 | -5 | $1,441 | $972,056 | 11 | Sony Pictures Releasing | false | false |
| 17 | 9 | Going the Distance | $7,979 | -69.9% | 10 | -12 | $797 | $305,520 | 5 | Warner Bros. | false | false |
| 18 | 13 | Micmacs | $6,701 | -44.3% | 10 | - | $670 | $27,985 | 2 | Sony Pictures Releasing | false | false |
| 19 | 18 | Daybreakers | $5,525 | +39.6% | 5 | - | $1,105 | $127,169 | 7 | Venus | false | false |
| 20 | 16 | Oceans | $5,355 | +24.4% | 13 | -3 | $411 | $549,469 | 9 | Cine Colombia | false | false |
| 21 | 20 | The Box | $3,948 | +56.2% | 4 | +1 | $987 | $76,707 | 5 | Cine Colombia | false | false |
| 22 | 22 | The Burning Plain | $3,728 | +168.4% | 6 | +3 | $621 | $59,033 | 5 | Cine Colombia | false | false |
| 23 | 17 | Halloween II | $2,126 | -47.5% | 5 | +2 | $425 | $115,811 | 8 | Cine Colombia | false | false |
| 24 | 23 | Shrek Forever After | $1,616 | +35.8% | 6 | +1 | $269 | $6,842,913 | 15 | United International Pictures | false | false |
| 25 | 19 | City of Life and Death | $760 | -75.9% | 1 | -1 | $760 | $11,196 | 3 | Cineplex | false | false |
