| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Elite Squad 2: The Enemy Within | $7,246,994 | -8.1% | 739 | +29 | $9,806 | $23,582,040 | 2 | N/A | false | false |
| 2 | 2 | Legend of the Guardians: The Owls of Ga'Hoole | $1,246,435 | -18.6% | 279 | -10 | $4,467 | $5,019,351 | 2 | Warner Bros. | false | false |
| 3 | 3 | Eat Pray Love | $1,092,309 | -22.2% | 237 | +1 | $4,608 | $6,823,745 | 3 | Sony Pictures Releasing | false | false |
| 4 | 4 | Grown Ups | $647,903 | -20.6% | 175 | - | $3,702 | $5,780,718 | 4 | Sony Pictures Releasing | false | false |
| 5 | - | Life as We Know It | $397,444 | - | 77 | - | $5,161 | $397,444 | 1 | Warner Bros. | true | false |
| 6 | 5 | Astral City: A Spiritual Journey | $328,228 | -36.5% | 291 | -49 | $1,127 | $20,573,537 | 7 | 20th Century Fox International | false | false |
| 7 | 6 | Vampires Suck | $222,480 | -36% | 125 | -6 | $1,779 | $1,920,985 | 3 | 20th Century Fox International | false | false |
| 8 | 7 | Resident Evil: Afterlife | $147,909 | -38.3% | 138 | -4 | $1,071 | $9,281,224 | 5 | Sony Pictures Releasing | false | false |
| 9 | - | Avatar 2010 Special Edition | $119,686 | - | 79 | - | $1,515 | $119,686 | 1 | 20th Century Fox International | true | false |
| 10 | 8 | Wall Street: Money Never Sleeps | $114,149 | -49.4% | 59 | -41 | $1,934 | $2,360,766 | 4 | 20th Century Fox International | false | false |
| 11 | 9 | The Last Exorcism | $65,590 | -55.4% | 73 | -59 | $898 | $1,992,931 | 4 | PlayArte Pictures | false | false |
| 12 | 11 | The Switch | $63,518 | +7.6% | 43 | +10 | $1,477 | $1,866,954 | 5 | N/A | false | false |
| 13 | 10 | Me and My Umbrella | $46,807 | -43.9% | 76 | -3 | $615 | $292,580 | 2 | 20th Century Fox International | false | false |
| 14 | - | So Hard to Forget | $42,095 | - | 22 | - | $1,913 | $42,095 | 1 | Europa Filmes | true | false |
| 15 | 16 | Nanny McPhee Returns | $39,291 | +32.3% | 39 | - | $1,007 | $734,725 | 5 | Universal Pictures International (UPI) | false | false |
| 16 | 13 | Brother and Sister | $34,557 | -28.1% | 12 | -1 | $2,879 | $125,974 | 2 | N/A | false | false |
| 17 | 14 | Despicable Me | $30,659 | -35.3% | 108 | -72 | $283 | $13,663,191 | 11 | Universal Pictures International (UPI) | false | false |
| 18 | 12 | The Karate Kid | $26,232 | -45.7% | 52 | -37 | $504 | $10,110,687 | 8 | Sony Pictures Releasing | false | false |
| 19 | 15 | The Last Airbender | $21,845 | -28.1% | 70 | -18 | $312 | $9,633,426 | 9 | Paramount Pictures International | false | false |
| 20 | 18 | Going the Distance | $13,779 | -6.6% | 14 | -6 | $984 | $1,576,263 | 6 | Warner Bros. | false | false |
| 21 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $11,803 | -29.4% | 34 | -13 | $347 | $3,638,716 | 7 | Warner Bros. | false | false |
| 22 | 20 | The Sorcerer's Apprentice | $8,520 | -18.1% | 22 | -2 | $387 | $5,000,143 | 10 | Walt Disney Pictures | false | false |
| 23 | - | The Runaways | $6,147 | - | 5 | - | $1,229 | $30,458 | 2 | Paris Filmes | false | false |
| 24 | 22 | Solomon Kane | $6,072 | +20.9% | 12 | - | $506 | $629,472 | 6 | Paris Filmes | false | false |
| 25 | 28 | Hot Tub Time Machine | $4,717 | +893.1% | 22 | +19 | $214 | $631,790 | 6 | N/A | false | false |
| 26 | 19 | Toy Story 3 | $4,353 | -65.1% | 20 | -46 | $217 | $24,993,351 | 18 | Walt Disney Pictures | false | false |
| 27 | 23 | The Expendables | $2,218 | -30.3% | 5 | -5 | $443 | $5,668,452 | 10 | N/A | false | false |
| 28 | 21 | Inception | $1,790 | -79% | 3 | -5 | $596 | $10,315,556 | 11 | Warner Bros. | false | false |
| 29 | 27 | 5x Favela: Now by Ourselves | $1,422 | +4% | 7 | -3 | $203 | $764,380 | 8 | Sony Pictures Releasing | false | false |
| 30 | 25 | Killers | $1,407 | -37.5% | 4 | -8 | $351 | $2,513,311 | 8 | N/A | false | false |
| 31 | 26 | The Well Beloved One | $1,055 | -43.9% | 7 | -3 | $150 | $4,952,158 | 13 | Walt Disney Pictures | false | false |
| 32 | 30 | A Prophet | $355 | +157.2% | 1 | - | $355 | $162,394 | 18 | Sony Pictures Releasing | false | false |
| 33 | - | The Last Song | $257 | - | 1 | - | $257 | $111,729 | 19 | Walt Disney Pictures | false | false |
| 34 | 24 | Salt | $59 | -97.8% | 1 | -1 | $59 | $7,383,615 | 12 | Sony Pictures Releasing | false | false |
| 35 | 29 | The Imaginarium of Doctor Parnassus | $58 | -85.7% | 1 | -1 | $58 | $163,135 | 24 | Sony Pictures Releasing | false | false |
