| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Eat Pray Love | $284,826 | - | 43 | - | $6,623 | $284,826 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Legend of the Guardians: The Owls of Ga'Hoole | $199,671 | -27.1% | 71 | -1 | $2,812 | $541,255 | 2 | Warner Bros. | false | false |
| 3 | - | Dark World | $133,358 | - | 53 | - | $2,516 | $133,358 | 1 | N/A | true | false |
| 4 | 2 | The Other Guys | $83,192 | -45.8% | 45 | - | $1,848 | $278,782 | 2 | Sony Pictures Releasing | false | false |
| 5 | 4 | Wall Street: Money Never Sleeps | $59,978 | -46.9% | 34 | +1 | $1,764 | $205,326 | 2 | 20th Century Fox International | false | false |
| 6 | 3 | Resident Evil: Afterlife | $55,508 | -51.9% | 89 | -7 | $623 | $1,654,496 | 4 | Sony Pictures Releasing | false | false |
| 7 | 5 | The Edge | $22,804 | -68% | 40 | -5 | $570 | $227,069 | 3 | N/A | false | false |
| 8 | - | The Devil's Flower | $12,736 | - | 4 | - | $3,184 | $12,736 | 1 | N/A | true | false |
| 9 | 7 | Sea Rex 3D: Journey to a Prehistoric World | $9,669 | -47.8% | - | - | - | $81,983 | 3 | N/A | false | false |
| 10 | 6 | Going the Distance | $6,645 | -71.2% | 17 | -25 | $390 | $311,068 | 5 | Warner Bros. | false | false |
| 11 | 11 | Inception | $6,487 | +25.1% | 5 | -2 | $1,297 | $1,481,586 | 12 | Warner Bros. | false | false |
| 12 | 12 | Avatar | $3,363 | -12.5% | 4 | +1 | $840 | $8,423,726 | 43 | 20th Century Fox International | false | false |
| 13 | 17 | Despicable Me | $793 | +161.7% | 5 | +3 | $158 | $1,095,412 | 13 | Universal Pictures International (UPI) | false | false |
| 14 | 16 | Toy Story 3 | $641 | +20.7% | 1 | -2 | $641 | $665,150 | 16 | Walt Disney Pictures | false | false |
| 15 | 14 | The Karate Kid | $545 | -45.7% | 6 | -3 | $90 | $318,261 | 8 | Sony Pictures Releasing | false | false |
| 16 | 20 | Shrek Forever After | $54 | -54.6% | 2 | +1 | $27 | $4,007,493 | 21 | Paramount Pictures International | false | false |
| 17 | 15 | Cats & Dogs: The Revenge of Kitty Galore | $46 | -95.2% | 1 | -1 | $46 | $514,885 | 11 | Warner Bros. | false | false |
| 18 | 19 | Tinker Bell and the Great Fairy Rescue | $33 | -87.2% | 1 | -3 | $33 | $82,686 | 9 | Walt Disney Pictures | false | false |
