| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Despicable Me | $454,029 | -7.8% | 86 | - | $5,279 | $2,798,552 | 4 | United International Pictures | false | false |
| 2 | 2 | The Last Airbender | $197,153 | -32% | 75 | +3 | $2,628 | $1,341,296 | 3 | Paramount Pictures International | false | false |
| 3 | 4 | Cats & Dogs: The Revenge of Kitty Galore | $160,125 | -12.6% | 78 | -3 | $2,052 | $720,006 | 3 | Roadshow Films | false | false |
| 4 | 3 | The Other Guys | $147,536 | -34.3% | 41 | -2 | $3,598 | $481,378 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | Legend of the Guardians: The Owls of Ga'Hoole | $138,143 | - | 80 | - | $1,726 | $226,219 | 1 | Roadshow Films | true | false |
| 6 | - | Dinner for Schmucks | $112,887 | - | 40 | - | $2,822 | $114,430 | 1 | Paramount Pictures International | true | false |
| 7 | 5 | Vampires Suck | $94,206 | -29.2% | 38 | - | $2,479 | $310,748 | 2 | 20th Century Fox International | false | false |
| 8 | 7 | The Sorcerer's Apprentice | $66,503 | -27.5% | 59 | +1 | $1,127 | $697,712 | 4 | Walt Disney Pictures | false | false |
| 9 | 9 | Diary of a Wimpy Kid | $65,347 | +3.8% | 52 | -1 | $1,256 | $275,921 | 3 | 20th Century Fox International | false | false |
| 10 | 6 | Wall Street: Money Never Sleeps | $61,133 | -34.3% | 58 | -1 | $1,054 | $450,853 | 3 | 20th Century Fox International | false | false |
| 11 | - | Buried | $54,661 | - | 40 | - | $1,366 | $54,661 | 1 | Hoyts Distribution | true | false |
| 12 | 8 | Grown Ups | $39,600 | -42.8% | 43 | -6 | $920 | $593,596 | 4 | Sony Pictures Releasing | false | false |
| 13 | 10 | Tomorrow, When the War Began | $26,925 | -34% | 35 | -6 | $769 | $1,018,277 | 6 | Paramount Pictures International | false | false |
| 14 | - | The Insatiable Moon | $23,925 | - | 22 | - | $1,087 | $35,360 | 1 | Rialto Distribution | true | false |
| 15 | 11 | I Am Love | $21,678 | -15.8% | 20 | - | $1,083 | $279,735 | 5 | Rialto Distribution | false | false |
| 16 | 13 | Inception | $19,293 | -19.9% | 34 | -7 | $567 | $4,454,966 | 12 | Warner Bros. | false | false |
| 17 | - | Last Night of the Proms | $16,422 | - | 14 | - | $1,173 | $16,422 | 1 | Rialto Distribution | true | false |
| 18 | 15 | Animal Kingdom | $16,048 | +9.4% | 16 | +3 | $1,003 | $125,317 | 4 | Madman Entertainment | false | false |
| 19 | 14 | Mother and Child | $16,024 | -32.9% | 19 | -3 | $843 | $141,899 | 4 | Hopscotch Films | false | false |
| 20 | 16 | The Concert | $11,266 | -15.4% | 14 | -1 | $804 | $299,820 | 8 | Hopscotch Films | false | false |
| 21 | 20 | Exit Through the Gift Shop | $8,615 | +10.1% | 13 | +4 | $662 | $160,301 | 5 | Madman Entertainment | false | false |
| 22 | 18 | Harry Brown | $8,560 | -26.9% | 22 | -5 | $389 | $353,208 | 8 | Hoyts Distribution | false | false |
| 23 | 12 | Charlie St. Cloud | $8,129 | -68.2% | 17 | -10 | $478 | $108,276 | 3 | United International Pictures | false | false |
| 24 | - | Anjaana Anjaani | $7,753 | - | 5 | - | $1,550 | $35,515 | 1 | - | true | false |
| 25 | 21 | The Girl Who Played with Fire | $6,177 | -18.7% | 14 | - | $441 | $793,848 | 11 | Rialto Distribution | false | false |
| 26 | 19 | Legend of the Fist: The Return of Chen Zhen | $4,757 | -40.6% | 4 | - | $1,189 | $58,250 | 3 | N/A | false | false |
| 27 | 23 | A Prophet | $3,710 | +4.4% | 3 | +1 | $1,236 | $59,143 | 5 | Sony Pictures Releasing | false | false |
| 28 | 17 | The Expendables | $3,705 | -71.9% | 21 | -7 | $176 | $797,357 | 6 | Roadshow Films | false | false |
| 29 | 25 | Beauty and the Beast 2010 3D Release | $3,372 | +1.9% | 1 | - | $3,372 | $58,367 | 9 | Walt Disney Pictures | false | false |
| 30 | 26 | Picture Me | $2,393 | -16.2% | 8 | -2 | $299 | $6,914 | 2 | Vendetta Films | false | false |
| 31 | 29 | South Solitary | $2,216 | -4.9% | 4 | -1 | $554 | $8,947 | 3 | Hoyts Distribution | false | false |
| 32 | 30 | Skin | $1,936 | -14.5% | 7 | +1 | $276 | $123,626 | 10 | - | false | false |
| 33 | 31 | Marmaduke | $1,875 | +66.2% | 7 | +1 | $267 | $563,118 | 15 | 20th Century Fox International | false | false |
| 34 | 22 | Going the Distance | $1,564 | -61.1% | 8 | -3 | $195 | $300,294 | 6 | Warner Bros. | false | false |
| 35 | - | With or Without You | $1,274 | - | 4 | - | $318 | $79,858 | 34 | - | false | false |
| 36 | 28 | The Runaways | $1,192 | -53.6% | 8 | -1 | $149 | $101,480 | 5 | Hoyts Distribution | false | false |
| 37 | 24 | Salt | $1,019 | -69.7% | 4 | -6 | $254 | $1,309,126 | 8 | Sony Pictures Releasing | false | false |
| 38 | 27 | Toy Story 3 | $892 | -67.4% | 5 | -5 | $178 | $4,109,690 | 15 | Walt Disney Pictures | false | false |
| 39 | - | Touch of Evil 2010 Re-release | $847 | - | 1 | - | $847 | $847 | 1 | - | true | false |
| 40 | - | I, Don Giovanni | $594 | - | 2 | - | $297 | $30,959 | 9 | - | false | false |
