| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Enthiran | $725,887 | -33.9% | 80 | - | $9,073 | $2,259,459 | 2 | Five Star | false | false |
| 2 | - | A Turtle's Tale: Sammy's Adventures | $307,353 | - | 81 | - | $3,794 | $307,353 | 1 | Golden Screen Cinemas | true | false |
| 3 | 3 | Detective Dee: The Mystery of the Phantom Flame | $222,571 | -33.7% | 62 | - | $3,589 | $671,634 | 2 | N/A | false | false |
| 4 | 2 | Legend of the Fist: The Return of Chen Zhen | $168,374 | -63.2% | 97 | - | $1,735 | $1,944,761 | 3 | Golden Screen Cinemas | false | false |
| 5 | 6 | Eat Pray Love | $114,208 | -11.8% | 25 | - | $4,568 | $296,399 | 2 | Sony Pictures Releasing | false | false |
| 6 | 4 | Magika | $109,364 | -63.9% | 58 | -6 | $1,885 | $919,819 | 3 | N/A | false | false |
| 7 | 5 | Legend of the Guardians: The Owls of Ga'Hoole | $66,374 | -70% | 68 | -17 | $976 | $768,607 | 3 | Warner Bros. | false | false |
| 8 | - | Dinner for Schmucks | $54,757 | - | 15 | - | $3,650 | $66,411 | 1 | United International Pictures | true | false |
| 9 | - | The Switch | $53,302 | - | 20 | - | $2,665 | $53,302 | 1 | N/A | true | false |
| 10 | 7 | Wall Street: Money Never Sleeps | $44,786 | -51.7% | 35 | - | $1,279 | $399,183 | 3 | 20th Century Fox International | false | false |
| 11 | 10 | Charlie St. Cloud | $34,940 | -38.4% | 15 | - | $2,329 | $126,594 | 2 | United International Pictures | false | false |
| 12 | - | The American | $30,819 | - | 17 | - | $1,812 | $30,819 | 1 | N/A | true | false |
| 13 | 9 | Alpha and Omega | $27,966 | -62.5% | 33 | - | $847 | $112,983 | 2 | N/A | false | false |
| 14 | 8 | Resident Evil: Afterlife | $23,872 | -70.8% | 48 | -42 | $497 | $3,543,124 | 5 | Sony Pictures Releasing | false | false |
| 15 | 13 | Blood Ties 2010 Re-release | $22,215 | -21.1% | 18 | - | $1,234 | $64,428 | 2 | N/A | false | false |
| 16 | 11 | Devil | $12,001 | -69.3% | 10 | -15 | $1,200 | $541,785 | 4 | United International Pictures | false | false |
| 17 | 12 | The Hole | $10,930 | -71.3% | 12 | -7 | $910 | $139,937 | 3 | N/A | false | false |
| 18 | 16 | Anjaana Anjaani | $6,682 | +5.5% | 2 | - | $3,341 | $15,396 | 2 | Five Star | false | false |
| 19 | 18 | Repo Men | $1,042 | -55.1% | 2 | - | $521 | $214,486 | 8 | United International Pictures | false | false |
| 20 | - | Vampires Suck | $861 | - | 3 | - | $287 | $511,157 | 7 | 20th Century Fox International | false | false |
| 21 | 20 | Avatar 2010 Special Edition | $834 | -37.8% | 1 | - | $834 | $363,752 | 7 | 20th Century Fox International | false | false |
| 22 | 22 | Cats & Dogs: The Revenge of Kitty Galore | $508 | -22.4% | 3 | - | $169 | $720,639 | 6 | Warner Bros. | false | false |
| 23 | 19 | Grown Ups | $261 | -81.5% | 2 | -2 | $130 | $766,955 | 7 | Sony Pictures Releasing | false | false |
| 24 | 23 | The Descent: Part 2 | $220 | -60.1% | 4 | -1 | $55 | $243,862 | 8 | Sony Pictures Releasing | false | false |
| 25 | 26 | The Back-up Plan | $126 | +20% | 1 | - | $126 | $287,964 | 15 | Sony Pictures Releasing | false | false |
| 26 | 25 | Going the Distance | $125 | -38.7% | 2 | - | $62 | $186,161 | 6 | Warner Bros. | false | false |
| 27 | 27 | Salt | $39 | +25.8% | 1 | - | $39 | $2,634,021 | 11 | Sony Pictures Releasing | false | false |
