| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $1,271,105 | -25.8% | 657 | -4 | $1,934 | $9,151,946 | 3 | Sony Pictures Releasing | false | false |
| 2 | - | Wall Street: Money Never Sleeps | $454,684 | - | 300 | - | $1,515 | $454,684 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | It's Not You, It's Me | $327,106 | -35.9% | 336 | -50 | $973 | $8,513,500 | 6 | Warner Bros. | false | false |
| 4 | 3 | Hell | $313,654 | -35.9% | 295 | -41 | $1,063 | $4,576,680 | 5 | N/A | false | false |
| 5 | 5 | Eat Pray Love | $266,348 | -32.6% | 150 | - | $1,775 | $856,089 | 2 | Sony Pictures Releasing | false | false |
| 6 | 6 | The Last Airbender | $196,944 | -47.4% | 309 | -148 | $637 | $13,857,463 | 6 | Paramount Pictures International | false | false |
| 7 | - | Charlie St. Cloud | $191,269 | - | 180 | - | $1,062 | $191,269 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 7 | The Expendables | $164,755 | -32.5% | 160 | -46 | $1,029 | $4,692,667 | 8 | N/A | false | false |
| 9 | 4 | Hidalgo. La historia jamás contada | $161,504 | -65.5% | 370 | -83 | $436 | $2,771,784 | 3 | 20th Century Fox International | false | false |
| 10 | 13 | Tinker Bell and the Great Fairy Rescue | $146,605 | +41.9% | 165 | +4 | $888 | $1,616,819 | 5 | Walt Disney Pictures | false | false |
| 11 | 11 | The Switch | $138,448 | +20% | 166 | +33 | $834 | $1,466,570 | 5 | Gussi Films | false | false |
| 12 | 8 | Mexico's Independence | $111,904 | -52% | 256 | -39 | $437 | $462,737 | 2 | N/A | false | false |
| 13 | 9 | Going the Distance | $110,900 | -49.4% | 112 | -120 | $990 | $1,276,177 | 3 | Warner Bros. | false | false |
| 14 | - | Piranha 3D | $99,778 | - | 150 | - | $665 | $99,778 | 1 | Gussi Films | true | false |
| 15 | 20 | The Secret of Moonacre | $80,090 | +130.2% | 89 | +24 | $899 | $601,710 | 7 | N/A | false | false |
| 16 | - | Arthur and the Revenge of Maltazard | $74,613 | - | 100 | - | $746 | $74,613 | 1 | N/A | true | false |
| 17 | 12 | The Joneses | $72,290 | -35.5% | 116 | -31 | $623 | $1,436,750 | 7 | N/A | false | false |
| 18 | 10 | Guardians of the Lost Code 3D | $70,283 | -54.9% | 140 | -110 | $502 | $814,266 | 3 | Videocine | false | false |
| 19 | 14 | Vampires Suck | $48,598 | -48.8% | 93 | -108 | $522 | $2,560,125 | 5 | 20th Century Fox International | false | false |
| 20 | 25 | Seres: Genesis | $42,178 | +123.4% | 71 | +60 | $594 | $183,092 | 2 | N/A | false | false |
| 21 | 19 | The Ghost Writer | $41,016 | -2.9% | 64 | +8 | $640 | $408,359 | 4 | Videocine | false | false |
| 22 | 15 | Dorian Gray | $35,944 | -39.9% | 59 | -9 | $609 | $1,151,188 | 9 | Gussi Films | false | false |
| 23 | 16 | Despicable Me | $26,074 | -49.4% | 76 | -31 | $343 | $19,789,795 | 10 | Universal Pictures International (UPI) | false | false |
| 24 | 17 | The Attempt Dossier | $23,072 | -53.9% | 118 | -50 | $195 | $900,314 | 6 | Videocine | false | false |
| 25 | - | The Messenger | $23,042 | - | 31 | - | $743 | $23,042 | 1 | N/A | true | false |
| 26 | 26 | Solomon Kane | $22,780 | +24.3% | 29 | -12 | $785 | $945,202 | 8 | N/A | false | false |
| 27 | - | La Vida Loca | $14,108 | - | 13 | - | $1,085 | $14,108 | 1 | N/A | true | false |
| 28 | 22 | The Girl with the Dragon Tattoo | $13,580 | -43.2% | 28 | -9 | $485 | $536,825 | 8 | Gussi Films | false | false |
| 29 | 23 | Grown Ups | $13,066 | -35.3% | 15 | -12 | $871 | $7,699,096 | 11 | Sony Pictures Releasing | false | false |
| 30 | 21 | Agora | $10,468 | -62.8% | 17 | -18 | $615 | $316,309 | 4 | Gussi Films | false | false |
| 31 | 24 | Veronika Decides to Die | $10,174 | -49.1% | 15 | -16 | $678 | $122,862 | 4 | N/A | false | false |
| 32 | 27 | Cats & Dogs: The Revenge of Kitty Galore | $9,738 | -30.6% | 22 | -18 | $442 | $3,793,783 | 8 | Warner Bros. | false | false |
