| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Eat Pray Love | $59,722 | - | 7 | - | $8,531 | $59,722 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Resident Evil: Afterlife | $45,966 | -37.3% | 8 | - | $5,745 | $139,145 | 2 | Jaguar Film International Distribution | false | false |
| 3 | 2 | Despicable Me | $43,333 | -3.4% | 8 | +1 | $5,416 | $181,243 | 3 | United International Pictures | false | false |
| 4 | 3 | Step Up 3D | $24,862 | -35% | 6 | -1 | $4,143 | $485,793 | 5 | Jaguar Film International Distribution | false | false |
| 5 | 4 | Going the Distance | $15,239 | -9.9% | 6 | - | $2,539 | $39,560 | 2 | Warner Bros. | false | false |
| 6 | 5 | The American | $12,805 | -19.1% | 7 | - | $1,829 | $33,763 | 2 | Italian International Film | false | false |
| 7 | - | Scott Pilgrim vs. the World | $11,248 | - | 5 | - | $2,249 | $11,248 | 1 | United International Pictures | true | false |
| 8 | 6 | Wall Street: Money Never Sleeps | $11,060 | -26.4% | 5 | -2 | $2,212 | $70,971 | 3 | 20th Century Fox International | false | false |
| 9 | 8 | The Other Guys | $10,050 | -23.8% | 5 | -1 | $2,010 | $95,332 | 4 | Sony Pictures Releasing | false | false |
| 10 | 7 | Dinner for Schmucks | $6,573 | -53% | 3 | -2 | $2,191 | $102,558 | 4 | United International Pictures | false | false |
| 11 | 9 | The Expendables | $6,427 | -28.5% | 5 | - | $1,285 | $178,714 | 5 | N/A | false | false |
| 12 | 11 | You Again | $3,573 | -41.4% | 4 | -1 | $893 | $27,575 | 3 | Walt Disney Pictures | false | false |
| 13 | - | The Descent: Part 2 | $3,471 | - | 4 | - | $867 | $3,471 | 1 | N/A | true | false |
| 14 | 16 | Knight and Day 2010 Re-release | $2,004 | +26% | 2 | - | $1,002 | $267,122 | 15 | 20th Century Fox International | false | false |
| 15 | 10 | Piranha 3D | $1,294 | -81.7% | 3 | -1 | $431 | $198,426 | 5 | Italian International Film | false | false |
| 16 | 14 | Everyday Is a Holiday | $1,172 | -60.5% | 2 | -1 | $586 | $5,756 | 2 | N/A | false | false |
| 17 | 19 | The Sorcerer's Apprentice | $1,162 | +57.5% | 2 | - | $581 | $190,705 | 13 | Walt Disney Pictures | false | false |
| 18 | 20 | Partir | $714 | +8.8% | 3 | - | $238 | $14,686 | 6 | Italian International Film | false | false |
| 19 | 15 | Inception | $666 | -74.1% | 1 | -1 | $666 | $555,232 | 11 | Warner Bros. | false | false |
| 20 | 13 | Cats & Dogs: The Revenge of Kitty Galore | $600 | -87% | 1 | -1 | $600 | $107,158 | 5 | Warner Bros. | false | false |
| 21 | 21 | Lembi 8 Giga | $538 | -8.3% | 1 | - | $538 | $213,136 | 12 | N/A | false | false |
| 22 | 23 | Triage | $419 | -2.8% | 1 | -1 | $419 | $4,033 | 4 | N/A | false | false |
| 23 | - | Son of Babylon | $165 | - | 1 | - | $165 | $165 | 1 | Italian International Film | true | false |
