| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Piranha 3D | $89,519 | - | 8 | - | $11,189 | $89,519 | 1 | N/A | true | false |
| 2 | 1 | Step Up 3D | $54,205 | -17.6% | 5 | -3 | $10,841 | $226,531 | 3 | N/A | false | false |
| 3 | - | Eat Pray Love | $53,513 | - | 4 | - | $13,378 | $53,513 | 1 | Sony Pictures Releasing | true | false |
| 4 | 3 | Inception | $28,345 | +4.2% | 5 | - | $5,669 | $823,636 | 13 | Warner Bros. | false | false |
| 5 | 2 | Wall Street: Money Never Sleeps | $20,664 | -34.6% | 4 | - | $5,166 | $58,141 | 2 | 20th Century Fox International | false | false |
| 6 | 4 | Despicable Me | $17,294 | -26% | 8 | - | $2,161 | $117,403 | 4 | United International Pictures | false | false |
| 7 | 5 | The Sorcerer's Apprentice | $12,387 | -12.2% | 6 | - | $2,064 | $200,599 | 6 | Walt Disney Pictures | false | false |
| 8 | 7 | The Other Guys | $8,360 | -4.8% | 3 | -1 | $2,786 | $76,288 | 4 | Sony Pictures Releasing | false | false |
| 9 | 9 | Splice 2010 Re-release | $8,000 | +29.2% | 8 | - | $1,000 | $25,548 | 3 | N/A | false | false |
| 10 | 8 | Going the Distance | $6,518 | -16.6% | 3 | -1 | $2,172 | $34,798 | 3 | Warner Bros. | false | false |
| 11 | 6 | Letters to Juliet | $4,193 | -63.5% | 4 | -2 | $1,048 | $18,806 | 2 | N/A | false | false |
| 12 | 10 | Knight and Day 2010 Re-release | $1,609 | -67.4% | 2 | +1 | $804 | $446,625 | 15 | 20th Century Fox International | false | false |
| 13 | 11 | Cats & Dogs: The Revenge of Kitty Galore | $1,587 | -50.7% | 1 | -2 | $1,587 | $61,604 | 5 | Warner Bros. | false | false |
| 14 | 13 | Predators | $1,158 | -55.1% | 2 | -1 | $579 | $58,783 | 7 | 20th Century Fox International | false | false |
| 15 | - | She's Out of My League | $794 | - | 1 | - | $794 | $54,380 | 14 | United International Pictures | false | false |
| 16 | 14 | The Losers | $215 | -35% | 2 | - | $107 | $29,154 | 6 | Warner Bros. | false | false |
| 17 | 15 | Shrek Forever After | $146 | +12.3% | 1 | - | $146 | $254,350 | 15 | United International Pictures | false | false |
| 18 | 16 | The Last Airbender | $65 | -1.5% | 2 | +1 | $32 | $194,353 | 12 | United International Pictures | false | false |
