| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $105,041 | -50.6% | 49 | - | $2,143 | $834,217 | 3 | Sony Pictures Releasing | false | false |
| 2 | 2 | Tinker Bell and the Great Fairy Rescue | $60,049 | -26.4% | 17 | - | $3,532 | $159,527 | 2 | Walt Disney Pictures | false | false |
| 3 | - | The Spy Next Door 2010 Re-release | $52,051 | - | 15 | - | $3,470 | $52,051 | 1 | N/A | true | false |
| 4 | - | Wall Street: Money Never Sleeps | $41,464 | - | 25 | - | $1,658 | $41,464 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | The Expendables | $33,067 | -35.9% | 16 | - | $2,066 | $110,670 | 2 | N/A | false | false |
| 6 | 5 | Grown Ups | $21,058 | -27.9% | 25 | - | $842 | $280,901 | 4 | Sony Pictures Releasing | false | false |
| 7 | - | Letters to Juliet | $20,389 | - | 11 | - | $1,853 | $20,389 | 1 | Venus | true | false |
| 8 | 4 | Battle for Terra | $15,995 | -51.1% | 10 | - | $1,599 | $58,174 | 2 | N/A | false | false |
| 9 | 6 | Cats & Dogs: The Revenge of Kitty Galore | $12,007 | -48.3% | 26 | +5 | $461 | $851,544 | 6 | - | false | false |
| 10 | - | Kick-Ass | $7,697 | - | 13 | - | $592 | $25,618 | 2 | United International Pictures | false | false |
| 11 | - | The Last Airbender | $6,265 | - | 4 | - | $1,566 | $495,426 | 5 | United International Pictures | false | false |
| 12 | 7 | The Sorcerer's Apprentice | $5,444 | -30.1% | 15 | - | $362 | $821,510 | 10 | Walt Disney Pictures | false | false |
| 13 | 8 | Inception | $2,383 | -55.4% | 2 | -4 | $1,191 | $518,908 | 8 | - | false | false |
| 14 | 11 | The Losers | $1,814 | -50.1% | 6 | - | $302 | $35,383 | 13 | - | false | false |
| 15 | 12 | The Karate Kid | $1,540 | -43.3% | 11 | - | $140 | $569,759 | 7 | Sony Pictures Releasing | false | false |
| 16 | 9 | Law Abiding Citizen | $1,271 | -71.6% | 10 | -1 | $127 | $49,378 | 14 | - | false | false |
| 17 | 13 | Nine | $875 | -52.9% | 6 | - | $145 | $56,856 | 35 | Sony Pictures Releasing | false | false |
| 18 | 14 | Cop Out | $513 | -62.1% | 4 | -4 | $128 | $14,755 | 4 | - | false | false |
